Protein Alignment MYH2 and MYO1

DIOPT Version :10

• Sequence 1: NP_060004.3
• Gene: MYH2 / 4620
• HGNCID: 7572
• Length: 1941
• Species: Homo sapiens
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 2133
• Identity: 619/2133 - (29%)
• Similarity: 1005/2133 - (47%)
• Gaps: 448/2133 - (21%)

Human    38 VFVAEPKESFVKGTIQSREGGKVTV--------------KTEGGATLTVKDDQVFPMNPPKYDKI 88
            |::.:.||.||||.:.|.:..|...              .||....:.|:...|||:||..:||:
Yeast    13 VWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKV 77

Human    89 EDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGK------- 146
            |:|:.:|||:||:|||||::||...:||||||||.|.:|||..|.:|..:.:..|..|
Yeast    78 ENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKS 142

Human   147 -----KRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKK 206
                 ..::.|||||:|::.||:.:|::.::||||:|||||||||.|||:::||.|:|.......
Yeast   143 RLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSN 207

Human   207 KEEITSGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLL 271
            ...::...|..:.|.:|:.:||:||:||||:||||:|||||||||:|.|...|.:..|.||.|||
Yeast   208 IAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLL 272

Human   272 EKSRVVFQLKAERSYHIFYQITSN-KKPELIEMLLITTNPYDYPFVS-QGEISVASIDDQEELMA 334
            ||||:|.|...||:||||||:.|. ...||..:.|.:.|..||..:| ..:..:..|:|.|....
Yeast   273 EKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKE 337

Human   335 TDSAIDILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSL--NSAD 397
            ..||::|:||:.::...|:::...::..||::| ...|.|||....    |.:|...:|  :..|
Yeast   338 LLSALNIIGFSKDQIRWIFQVVAIILLIGNIEF-VSDRAEQASFKN----DVSAICSNLGVDEKD 397

Human   398 LLKALCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGV 462
            ...|:..||.|.|.|:|::.:..:|....:.||::.:||::|.::|..||:.||.......:||:
Yeast   398 FQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGL 462

Human   463 LDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELI 527
            |||||||||:.||.||||||:||||||||||:|||||||.||.||.|:|.:||:|.||...|:||
Yeast   463 LDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLI 527

Human   528 EK---PMGIFSILEEECMFPKATDTSFKNKL---YDQHLGKSANFQKPKVVKGKAEAHFALIHYA 586
            |.   |.|:..:|:||.:.||:||.||.:||   :||:   |:.|::.::..|     |.|.|||
Yeast   528 ESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQN---SSKFKRSRLKNG-----FILKHYA 584

Human   587 GVVDYNITGWLEKNKDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGE---GAGGGA-------KK 641
            |.|:|.:.|||.|||||||:.::.|...|....:::||.    .|||   .||..|       ||
Yeast   585 GDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQ----PEGEKSSSAGVEANISNQEVKK 645

Human   642 GGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLE 706
            ..:.  |:|:|.|:..||....|:..|.|||||||||||||..|........|:|.|||||||||
Yeast   646 SART--STFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLE 708

Human   707 GIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEK-----LLASIDIDHTQYKFGH 766
            |||:.|:|:|:||.:.:|.|||::|.........|....|||.|     ||.|:.:|...||.|:
Yeast   709 GIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGN 773

Human   767 TKVFFKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMN-V 830
            ||:|||||:|..||:.:|.||..::.:..|..||:..|.|....:::.:....|....|.:.. |
Yeast   774 TKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLV 838

Human   831 KHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
            |..||..||.:|||||.|:..........|:..|:|::|.:.|:|:|.||||....:.|..:.|.
Yeast   839 KEDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQD 903

Human   896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960
            .:..|.|.|                           .::|..:|        :::.....|:|..
Yeast   904 LLNQEKENL---------------------------RKNESLLN--------RVKTSSETLQKQF 933

Human   961 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
            |||.....::.:||......::...:::.||.|||    :|::|       ||:.|.:   |.|.
Yeast   934 DDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETI----REREA-------TLEKLHS---KNNE 984

Human  1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE 1090
            |.|       |:.||...:.:|:..:..::.:|.|||.::|..::.|...|.|.:..::||...|
Yeast   985 LIK-------QISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDKLSSSE 1042

Human  1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155
                      ||.....:.|:|......:|::.|..|....|:.....:|:::.|:.:|
Yeast  1043 ----------EDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQL------ 1091

Human  1156 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
                           |.:|:|..||:..::    .|:...||..|:..|:|:|.|
Yeast  1092 ---------------KNKESELLKMKEKID----NHKKELATFSKQRDDAVSEHG---------- 1127

Human  1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR 1285
             |:..|..|.::::.:..||.:.:.:...|.::            ::||:||::
Yeast  1128 -KITAELKETRIQLTEYKSNYQKIKEEYSNFQR------------ETKEQEQKK----------- 1168

Human  1286 LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK---------AKNALAHALQS 1341
                          :.:||..|:..|      |:||:.:|.:||.         :.|::...:.|
Yeast  1169 --------------RNSLVESLNDSK------IKELEARLSQEISLNQYLNKRISGNSVETNISS 1213

Human  1342 SRHDC----------DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE--- 1393
            :|...          |::::.|:            |..|.||:              |..||
Yeast  1214 TRRSTSYSDDPLDKEDIIKKYYD------------LQLAFTEI--------------TRNLENEI 1252

Human  1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK---KQRNF 1455
            |.||.|..||:..|..:.:.:.:...::...::|:..::|:...:...:.....||.   |:.:.
Yeast  1253 EEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDI 1317

Human  1456 DKILAE---WKQKCE-ETHAELEAS-------------QKEARSLGTELFKIK-NAYEESL---- 1498
            :|::.|   .|::.: ||.|..:|.             |.|:....::::|:| .|.||.:
Yeast  1318 NKLMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEASEERVKSLE 1382

Human  1499 DQLETLK-RENKNL--------QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
            |:|:|:. |:..||        :..||...|:|     |.::||..|         ||..|.|:
Yeast  1383 DKLKTMPLRDRTNLPVGDIIKNRDSISKYEEEI-----RYYKLENYK---------LQEILNES- 1432

Human  1555 ASLEHEEGKILRIQLELNQVKS-------EVDR-----KIAEKDEEI----------------DQ 1591
                  .||:.::.|:|.|.||       ::||     :..|:.:|:                |.
Yeast  1433 ------NGKLSQLTLDLRQSKSKEALLSEQLDRLQKDLESTERQKELLSSTIKQQKQQFENCMDD 1491

Human  1592 LKRNHIRIVESMQSTLDAEIRSRNDAI---RLK---KKMEGDLNEMEIQLNHANRMAAEALRNYR 1650
            |:.|.:|:.|.:.:...||...:|.|.   :||   |:.|..:.|.|::.|.::....|.|...:
Yeast  1492 LQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELK 1556

Human  1651 NTQG---ILKDTQIHLDDALRSQED----------LKEQL------------------AMVERRA 1684
            ..|.   ||.|...||.:.|.:.||          |||:|                  ..:|...
Yeast  1557 RVQDVKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETST 1621

Human  1685 NLLQAEIEELRATLEQTERSRKI-------------AEQELLDASERV----QLLHTQNTSLINT 1732
            |..:|:|.:|   |:|.:...|:             ||:||....|.:    :.|..:..||...
Yeast  1622 NDSEAKISDL---LKQLDHYTKVVEMLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKI 1683

Human  1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE-LKKEQDTSAHLERMKKNMEQTV 1796
            |::||:|::|....:: |...|.::..:..|.||:.....|| |:.:.:.::....:.|.::.:.
Yeast  1684 KQELESDLNQKTDALQ-ISNAALSSSTQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASC 1747

Human  1797 KDLQLRLDEAEQ--LALKGGKKQIQKLE------------------------ARVRELEGEVESE 1835
            ...:.:.|:.:|  :.|....:.:|||.                        :::.|||..|..|
Yeast  1748 NGYKDKFDDEKQKNIDLYEENQTLQKLNTDLQLQLKNLHERLSDTTEKNAWLSKIHELENMVSLE 1812

Human  1836 QKRNAEAVKGLRKHERRVKEL----TYQT---EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1893
            .....|.:|..:..||.|:||    :.||   |...||....::...|.:|::...::...:.|.
Yeast  1813 TDLKYEEMKKNKSLERAVEELQTKNSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQEL 1877

Human  1894 QSNTNLA-------KFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVIS 1939
            :...::.       |.:::..|:|..:.|.:  .:.:....:.|....:|:.|
Yeast  1878 EMKKSIRDNSSYRDKVQEMAQEIEFWKSRYE--STMIGSKNIDSNNAQSKIFS 1928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH2	NP_060004.3	Myosin_N	33..77	CDD:460670	12/52 (23%)
		MYSc_Myh2_mammals	100..772	CDD:276877	306/708 (43%)
		Actin-binding. /evidence=ECO:0000250	661..683		14/21 (67%)
		Actin-binding. /evidence=ECO:0000250	763..777		9/13 (69%)
		Myosin_tail_1	852..1929	CDD:460256	256/1255 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1149		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1174		1/18 (6%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	575/1891 (30%)
		Smc	1607..>1901	CDD:440809	58/297 (20%)