DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH2 and didum

DIOPT Version :9

Sequence 1:NP_001093582.1 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2029 Identity:512/2029 - (25%)
Similarity:890/2029 - (43%) Gaps:431/2029 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    44 KESFVKGTIQSREGGKVTVKTEGGATLTVK---DDQVFP--MNPPKYDKIEDMAMMTHLHEPAVL 103
            :||:.||      .|.:.:.|:.|....||   |....|  .||.......|:..:::||||.||
  Fly    29 EESYRKG------AGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87

Human   104 YNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHIFSISDNAYQFML 167
            :||:.|:. ..:||||.|:..|.:|||..:|:|.|.::.||||....:..||||::::.||..:.
  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152

Human   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGTLEDQIISANPLLEA 232
            .:..|.||:::|||||||||:.|..::|||  ||.|.:.:.::         |.::::::|::||
  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSESETQV---------ERKVLASSPIMEA 206

Human   233 FGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVVFQLKAERSYHIFYQITS 294
            ||||||.|||||||||||.::.| ...|.  |..|.:.||||||||||:|.:.||:||||||:.:
  Fly   207 FGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCA 271

Human   295 --NKKPELIEMLLITTNPYDYPFVSQGEI-SVASIDDQEELMATDSAIDILGFTNEEKVSIYKLT 356
              :|.||     |:..:...:.|::.|.. .:..:.|.|:...|..|:.:|||:.::...|.|:.
  Fly   272 ARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331

Human   357 GAVMHYGNLKFKQKQRE--EQAEPDGTEVADKAAYLQSLNSADLLKA--------LCYPRVKVGN 411
            ..::|.||::..:|..|  |:.:.|..::.....:||.  :||||:.        |...:::..|
  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI--TADLLRVSADDLRRWLLMRKIESVN 394

Human   412 EYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSL 476
            |||....::|....|..||||.:|.|:|.::|..:|:.|:....:..|||||||.|||.|:.||.
  Fly   395 EYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSF 459

Human   477 EQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEEC 541
            ||.|||:.||||||.||.|:|.||||||.||||.||.||| .|...||:|||..:|:..:|:|||
  Fly   460 EQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEEC 523

Human   542 MFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYAGVVDYNITGWLEKNKDPLNE 606
            ..||.:|.|:..||..: ..|..:|:||:.    ....|.:.|::..|:|::.|:||||:|.:::
  Fly   524 RMPKGSDESWAGKLIGK-CNKFPHFEKPRF----GTTSFFIKHFSDTVEYDVNGFLEKNRDTVSK 583

Human   607 TVVGLYQKSAMKTLAQLFS-------GAQTAEGEGAGGGA--KKGGKKKGSSF-----------Q 651
            .:..:..:|.|....|:.:       ...:|:....||..  ..|.|::|:..           :
  Fly   584 ELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRK 648

Human   652 TVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFP 716
            ||.:.|:|:|..|::.|.:|.||:||||.||:.|.....|...::.|||..||||.:||...|||
  Fly   649 TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFP 713

Human   717 SRILYADFKQRYKVL-NASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLE 780
            ||.||.||..||::| ..|.:.:.   |.|.:...::.....|..:|:||:|::||:||.:..||
  Fly   714 SRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLE 775

Human   781 EMRDD-----------------------KLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQY 822
            ::|.:                       ::.::|...|...||:|||...|:|.|.|..:...:|
  Fly   776 QVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY 840

Human   823 NIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKR-------KELE 880
                   .:.|...:.:.:::..:...:|.......:.:|..::|.....:.:|       :...
  Fly   841 -------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAY 898

Human   881 EKMVTLLKEKNDLQLQ--------------VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTER 931
            :|     :.:|.:..|              ::|||:.::..|.:...|....|.::.:|.|:...
  Fly   899 QK-----RRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRD 958

Human   932 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA 996
            ..:.:...:|::..|.||     ||||.::      |:.:..|.|.::|           |:.|.
  Fly   959 NSNLKHKTSEISVLKMKL-----ELKKTLE------AEFKNVKAACQDK-----------DKLIE 1001

Human   997 KLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL 1061
            .|.|:              |:||.|:...|      ||:.....|..:.|::..|.:.|..:|::
  Fly  1002 ALNKQ--------------LEAERDEKMQL------LEENGHAQEEWISQKQTWRQENEELRRQI 1046

Human  1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE 1126
            :..:.:|:.:.::..|::.::..::..:|.. ...|..|:|::.:..: ...:||..:|:.....
  Fly  1047 DEIIDMAKNAEVNQRNQEDRMLAEIDNRELN-EAYQRAIKDKEVIENE-NFMLKEELSRLTAGSF 1109

Human  1127 EIEAERASRAKAE----------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1181
            .:.|.:||.|.::          |...|::|..:.:|:.. ....:||..:::....|.|.||.:
  Fly  1110 SLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQKHK 1173

Human  1182 RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
                  .||.:....:.|.|..:....:.|           ||.|..:::.|.|.|.:::     
  Fly  1174 ------VLQEQYIKLSSRHKPTEDSFRVSE-----------LEVENEKLRSEYDQLRTSI----- 1216

Human  1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS--- 1308
             |..:|                       ||:|.||...||.|......:..:.:|::.|.|   
  Fly  1217 -KHGVE-----------------------INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSM 1257

Human  1309 ----------RGK------QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL--LREQYEE 1355
                      ||.      :||..| :.:.||||.|:||        .:..|:..|  :.::.|.
  Fly  1258 RSLEPESLQMRGNDVNELMEAFHSQ-KLINRQLESELKA--------ITEEHNSKLVEMTQEIER 1313

Human  1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL--EEAKKKLAQRLQAAEEHVEAVNAKCA 1418
            ....|.|||:.:.::..|...    ...|.:::.:..  .|.:|.:||.|...|| ::..|||..
  Fly  1314 LNNEKDELQKVMFESIDEFED----SNVDTLRQNDRYLRRELQKAVAQFLLVQEE-LKLANAKLK 1373

Human  1419 SLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
            :..:...:|::::|:.|:                          :.|...|.|::.|:..:.:|.
  Fly  1374 AYRQDGGQLEHKIEEEMI--------------------------RNKSNGTSADVGANVTKQKSQ 1412

Human  1484 GTE-LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG------------GKRIHELEKI 1535
            ..: |.|.   :...||::         ||:.:|.||.:...|            ..|..:|...
  Fly  1413 NPQGLMKF---HSSDLDKI---------LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNA 1465

Human  1536 KKQVEQEKCELQAALEEAEASLEHEEGKILRI-----QLELNQVKSEVDRKIAEKDEEIDQLKRN 1595
            ...|.:...:....:::...:....|.:::.:     .|.|.:...:||..:....|:.:|.:..
  Fly  1466 DDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLK 1530

Human  1596 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ 1660
            :..:.|..:..||                      :.:.|..|..|..:.|.:.:....||.:.:
  Fly  1531 NFNLFEYRRVILD----------------------LIVNLYQALIMQIQGLLDPKIVPAILNNDE 1573

Human  1661 IHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLD--ASERV--QL 1721
            |...   |....::.:...:...::.........:..:.|.|...|..:...||  .:|::  ||
  Fly  1574 IQRG---RQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQL 1635

Human  1722 LHTQNTSLINTKKKLETDISQMQ---------GEMEDILQEARNAEE--KAKKAITDAAMMAEEL 1775
            |:......:|. ..|..||...:         |.:||.::..:.:.:  .|...:...:.:.:..
  Fly  1636 LYFICAVALNC-LMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSR 1699

Human  1776 KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL-ALKGGK--------------KQIQKLEARV 1825
            |.|||.            ||:.||...|..|:.| .:|..|              |..:||.|| 
  Fly  1700 KSEQDV------------QTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNAR- 1751

Human  1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTE--EDRKNILRLQDLVDKLQAKVKSYKRQA 1888
                    ..||.|::             |.|...:  :..|.:.|..|:             :.
  Fly  1752 --------QMQKSNSD-------------EFTIDQKFIQPFKVVFRYSDI-------------KL 1782

Human  1889 EEAEEQSNTNLAKF 1902
            |:.|..|:.||.:|
  Fly  1783 EDIELPSHLNLDEF 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH2NP_001093582.1 Myosin_N 36..73 CDD:280832 7/28 (25%)
Myosin_head 88..772 CDD:278492 271/721 (38%)
MYSc_Myh2_mammals 100..772 CDD:276877 267/709 (38%)
Actin-binding. /evidence=ECO:0000250 661..683 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 763..777 7/13 (54%)
Myosin_tail_1 852..1929 CDD:279860 208/1155 (18%)
RILP-like 967..1100 CDD:304877 24/132 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 2/18 (11%)
DUF342 <1672..1769 CDD:302792 17/111 (15%)
didumNP_724569.1 MYSc 65..778 CDD:214580 278/739 (38%)
MYSc_Myo5 84..767 CDD:276831 267/709 (38%)
IQ 900..922 CDD:197470 3/26 (12%)
GBP_C <971..1086 CDD:303769 32/157 (20%)
coiled coil 1049..1068 CDD:293879 2/18 (11%)
coiled coil 1077..1086 CDD:293879 2/9 (22%)
JAKMIP_CC3 <1190..1299 CDD:292653 32/157 (20%)
Myo5_CBD 1424..1792 CDD:271254 75/449 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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