DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH2 and ck

DIOPT Version :9

Sequence 1:NP_001093582.1 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2241 Identity:549/2241 - (24%)
Similarity:922/2241 - (41%) Gaps:566/2241 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    27 AQNRPFDAKTSVFVAEPKESFVKGTIQSREGGKVTVKTEGGATLTVKDD-QVFPMNPPKYDKIED 90
            |..|.||..            :...:.|.||.::.|:.:.|..:.:..: ::..|:......:||
  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67

Human    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHI 155
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132

Human   156 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGTLE 220
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|            ||| ...:|
  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI------------SGK-HSWIE 184

Human   221 DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLKAERS 285
            .||:.|||:|||||||||:||||||||||:|.|||...|.:..|.||.|||||||:|.|..:||:
  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249

Human   286 YHIFYQI----TSNKKPEL-IEMLLITTNPYDYPFVSQG-EISVASIDDQEELMATDSAIDILGF 344
            ||:||.|    ::::|..| :.|..      ||.:::.| .|:....||..|.....||:.:|.|
  Fly   250 YHVFYCILAGLSADEKSRLDLGMAA------DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308

Human   345 TNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEV-----ADKAAYLQSLNSADLLKALCY 404
            :::|...|.||..|::|.||:|:|....:..   |.||:     .::.|.|..|....|:.||..
  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTR 370

Human   405 PRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPR---QYFIGVLDIA 466
            ..:....|.|....:.:|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.
  Fly   371 RTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIF 433

Human   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KP 530
            |||.||.||.||.|||:.||.|||||..|:|.||||||..|.|.|..|:| :|....::||. |.
  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQ 497

Human   531 MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYAGVVDYNITG 595
            :.|.::::||..|||.||.:...||:..| |...|:.||   |......|.|.|:||||.|:..|
  Fly   498 LNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRG 558

Human   596 WLEKNKDPLNETVVGLYQKSAMKTLAQLFS-----GAQTAEGEGAGGGAKKGGKKKGSSFQTVSA 655
            :|:||:|..:..::.|..:|..|.|.|:|:     ||:|              :|:   ..|:|.
  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAET--------------RKR---TPTLST 606

Human   656 LFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRIL 720
            .||::|:.||..|.|..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..
  Fly   607 QFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHG 671

Human   721 YADFKQRYKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDD 785
            :.:|.:||:.| ...:|.....|.:.|:.::.|.: :..:.|:.||||||.|......||:.||.
  Fly   672 FREFVERYRFL-IPGVPPAHRTDCQAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDR 734

Human   786 KLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKL-FFKIKPLLKSA 849
            .|.:.|...|...||::.|   :|.:..|.|...:|...:.:...|.:..|:: :.:::.|::| 
  Fly   735 VLTRKILILQRSIRGWVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS- 795

Human   850 ETEKEMATMKEEFQKIKDEL------AKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
                  ..:...|:.::..:      |:....|:|...||..::|.::.::..:         |.
  Fly   796 ------RVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AM 845

Human   909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 973
            .|     ..|::||.|     :.||         ..:.||||::  ||..            ...
  Fly   846 RR-----YRKLRLEHK-----QFAE---------VLQLRKLEEQ--ELLH------------RGN 877

Human   974 KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038
            |||.|...::..:.:..|         |::.:||    .|::.:..|..:|.:..|..|.|:.||
  Fly   878 KHAREIAEQHYRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVD 929

Human  1039 D---LEGSLE---------------QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
            |   :|...:               :|..:..||..|:...:.|: :|.   :.|..:::.|.| 
  Fly   930 DGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDI-IAP---IHISEDEEDLSE- 989

Human  1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1150
            .|.::|..:..|..:..:.|     :|.:|.....:....:::.|: |......:...|:.....
  Fly   990 FKFQKFAATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKY 1048

Human  1151 EISERLEEAG--GATSAQIEMNKKREAEFQK---MRRD------LEEATLQHEATAATLRKKHAD 1204
            ...:|::...  ...:|.:..|..|..|||:   |..|      .:..:::|:..:.||::|:  
  Fly  1049 HTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-- 1111

Human  1205 SVAELGEQI-----------DNLQ-----RVKQKLEK---------EKSEMKMEI-----DDLAS 1239
               :|||.:           |:.|     |....|||         .::|::.||     ..|.:
  Fly  1112 ---KLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTN 1173

Human  1240 NVETVSKAKGNL-----------------------------------EKMCRTLED--------- 1260
            |....|.|:|.:                                   |::.||..:         
  Fly  1174 NPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSW 1238

Human  1261 -QLSELKSKEEEQQRLINDLTAQRGRLQ-------TESGEFSRQLDEKEAL-------------- 1303
             :|...|||:.    ::..:|...|..:       |.:.|...||.:|.:|              
  Fly  1239 LELQATKSKKP----IMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFD 1299

Human  1304 -VSQLSRGKQAFTQQIEELKRQLEEE-IKAKNA------------------------------LA 1336
             ||.|..|.......|.:.::..:|: .:.:||                              :.
  Fly  1300 KVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVV 1364

Human  1337 HALQSSRHDCD-------LLREQYEEEQESKAELQR------------ALSKANTEVAQWRTKYE 1382
            ..::...:.||       :..:||..|..:...::|            .||..:..:.:|...  
  Fly  1365 RGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAAL-- 1427

Human  1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASL-EKTKQRLQNE-----VEDLMLDVERT 1441
              .:|..::....|.|:|. |:..|:.|.....|...| .:..:..:|.     ..|:::.|..|
  Fly  1428 --VLQAYKKSYYVKDKIAP-LKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWT 1489

Human  1442 NAACAALDKKQR-----NFDKILAEWKQKCEETHAELEASQKEARSLGT---ELFKIKNAYEESL 1498
            ..  ..:|.:::     :|.:|.|...||..:...       :..||.|   |.|..::...|.:
  Fly  1490 GV--YVVDDQEQVLLELSFPEITAVSSQKTNKVFT-------QTFSLSTVRGEEFTFQSPNAEDI 1545

Human  1499 DQ-----LETLKRENKNL-----QQEISDLTEQIA--EGGKRIHELEKIKKQV------------ 1539
            ..     |:.||:.:|.:     .:..||.|..::  :|...|.|.|...:.|            
  Fly  1546 RDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDR 1610

Human  1540 EQEKCELQAA--------------------LEEA-------------------------EASLEH 1559
            .||:.:..|.                    :|||                         |.:|:|
  Fly  1611 SQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDH 1675

Human  1560 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR--IVESMQS----------TLDAEIR 1612
                   .:|...:..|:.....:::.||:.:..|:.|:  ::..:||          ...|.::
  Fly  1676 -------FRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILK 1733

Human  1613 SRNDAIRLKKKMEGDL---------------NEMEIQL-----NHANRMAAE--------ALRNY 1649
            ...|....:.:|..::               :|:..||     ::.|||:.|        |...:
  Fly  1734 YMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLF 1798

Human  1650 RNTQGILKDTQIHL---------DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ----- 1700
            ..:||:||:..:.|         |...|.|:.::..    :|:....|.|:|.::....|     
  Fly  1799 ACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHG----QRKYPPHQVEVEAIQHKTTQIFHKV 1859

Human  1701 -----TERSRKI-----AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGE--------M 1747
                 |:.:.::     |:....:.|:|:.|..::..||.  .|..:..||..:|:        :
  Fly  1860 YFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLF--VKIADKVISVPEGDFFFDFVRHL 1922

Human  1748 EDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV------KDLQLRLDEA 1806
            .|.:::||...:.|....|.....                |||....||      .||.....:.
  Fly  1923 TDWIKKARPIRDGANPQFTYQVFF----------------MKKLWTNTVPGKDRNADLIFHYHQE 1971

Human  1807 EQLALKGGKKQIQKLEARVRELEGEVE-SEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRL 1870
            ....|:|..|..::..|::..|...|. .|.|:..:|:      .:.::||.      ..:|:::
  Fly  1972 LPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAI------PQMLRELI------PSDIMKI 2024

Human  1871 QDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901
            |...:..::.|.||.:......|.:.....|
  Fly  2025 QSTSEWKRSIVASYNQDGGMTSEDAKVAFLK 2055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH2NP_001093582.1 Myosin_N 36..73 CDD:280832 5/36 (14%)
Myosin_head 88..772 CDD:278492 282/703 (40%)
MYSc_Myh2_mammals 100..772 CDD:276877 276/691 (40%)
Actin-binding. /evidence=ECO:0000250 661..683 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 763..777 7/13 (54%)
Myosin_tail_1 852..1929 CDD:279860 238/1394 (17%)
RILP-like 967..1100 CDD:304877 30/150 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 3/20 (15%)
DUF342 <1672..1769 CDD:302792 21/119 (18%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 285/716 (40%)
MYSc_Myo7 77..721 CDD:276832 276/691 (40%)
MyTH4 <1138..1245 CDD:214535 16/106 (15%)
B41 1251..1467 CDD:214604 34/220 (15%)
FERM_B-lobe 1355..1439 CDD:271216 10/87 (11%)
FERM_C1_MyoVII 1461..1559 CDD:270019 20/106 (19%)
SH3 1560..1624 CDD:302595 12/63 (19%)
MyTH4 1701..1849 CDD:214535 27/151 (18%)
B41 1856..2068 CDD:214604 41/230 (18%)
FERM_M 1966..2068 CDD:278785 18/102 (18%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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