DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH2 and myp2

DIOPT Version :9

Sequence 1:NP_001093582.1 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens
Sequence 2:NP_593816.1 Gene:myp2 / 2543576 PomBaseID:SPAC4A8.05c Length:2104 Species:Schizosaccharomyces pombe


Alignment Length:2173 Identity:632/2173 - (29%)
Similarity:1036/2173 - (47%) Gaps:382/2173 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    20 SERERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSREGGKVTVKTE-GGATLTVKDDQVFPMNPP 83
            :|:.....::..||.:|.:::.:.||||||..|....|.|..||.| .|:...|.......:|||
pombe    22 AEKHCNAVKDASFDERTWIWIPDSKESFVKAWIVEDLGEKYRVKLERDGSERIVDGFDAEKVNPP 86

Human    84 KYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKR 148
            |:|.::|||.:|.|:||:|:.||.:||...:||||||||.|.||||..||:|..:||..|:.|:.
pombe    87 KFDMVDDMAALTCLNEPSVVNNLTQRYEKDLIYTYSGLFLVAVNPYCHLPIYGDDVVRKYQSKQF 151

Human   149 QEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSG 213
            :|..||||..:|.||:.:|..|.|||||:|||||||||..||:||||..::.       :..||.
pombe   152 KETKPHIFGTADAAYRSLLERRINQSILVTGESGAGKTETTKKVIQYLTSVT-------DASTSD 209

Human   214 KIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVF 278
            ..|  ||.:|:..||:|||||||:||||:|||||||||||.|...|.:..|:::.||||||||:.
pombe   210 SQQ--LEKKILETNPVLEAFGNAQTVRNNNSSRFGKFIRIEFSNNGSIVGANLDWYLLEKSRVIH 272

Human   279 QLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILG 343
            ....||:||:|||:.......|:|.|.:......|.::..|...:..:||.:|.......:..||
pombe   273 PSSNERNYHVFYQLLRGADGSLLESLFLDRYVDHYSYLKNGLKHINGVDDGKEFQKLCFGLRTLG 337

Human   344 FTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVK 408
            |.|.|..|::.:..:::|.||::....:..:...|..|:: |:..:|..:.....:.|..:|:.|
pombe   338 FDNNEIHSLFLIIASILHIGNIEVASDRSGQARFPSLTQI-DQLCHLLEIPVDGFVNAALHPKSK 401

Human   409 VGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQ-PRQYFIGVLDIAGFEIFD 472
            .|.|::...:|.|||.:.:.:|||.:||:.|..:|.|:||.:...| ....|||||||||||||.
pombe   402 AGREWIVTARTREQVVHTLQSLAKGLYERNFAHLVKRLNQTMYYSQSEHDGFIGVLDIAGFEIFT 466

Human   473 FNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK--PMGIFS 535
            |||.||||||||||||||||||:|||||||||.:|.|||.|||:|.||...|:.|||  |:||||
pombe   467 FNSFEQLCINFTNEKLQQFFNHYMFVLEQEEYTQERIEWDFIDYGNDLQPTIDAIEKSEPIGIFS 531

Human   536 ILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYAGVVDYNITGWLEKN 600
            .|:|:|:.|.|||.:|..||:....||| :..:||  |..:|. |.|.||||.|:|:...|||||
pombe   532 CLDEDCVMPMATDATFTEKLHLLFKGKS-DIYRPK--KFSSEG-FVLKHYAGDVEYDTKDWLEKN 592

Human   601 KDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKGGKKKGSSFQTVSALFRENLNKLM 665
            |||||..:..|..||....::.||.. .::...|.....|||      .|:|||...|..|:.||
pombe   593 KDPLNACLAALMFKSTNSHVSSLFDD-YSSNASGRDNIEKKG------IFRTVSQRHRRQLSSLM 650

Human   666 TNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKV 730
            ..|.:|.||||||||||..|.|..::..|||||||||||||||||.:.|||:::.|.:|:.||.:
pombe   651 HQLEATQPHFVRCIIPNNLKQPHNLDKSLVLHQLRCNGVLEGIRIAQTGFPNKLFYTEFRARYGI 715

Human   731 LNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQ 795
            |:.| :..| ::::|||:..::..:.:..|.|:.|.|||||||.:||.||:.|:..|..:.....
pombe   716 LSQS-LKRG-YVEAKKATITIINELKLPSTVYRLGETKVFFKASVLGSLEDRRNALLRVIFNSFS 778

Human   796 ARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKE 860
            ||.||||.|....|...|::|...:|:|:|....:|..||..||..:||||.:.:|::.:.....
pombe   779 ARIRGFLTRRRLYRFNHRQDAAILLQHNLRQLKLLKPHPWWNLFLHLKPLLGTTQTDEYLRRKDA 843

Human   861 EFQKIKDELAKSEAKRKELEEKMVTLLKEK-----NDLQLQVQAEAEGLADAEERCDQLIKTKIQ 920
            ....::::|..::....||     |:.||:     ||||     |.:.||..:   |.|::   :
pombe   844 LINNLQNQLESTKEVANEL-----TITKERVLQLTNDLQ-----EEQALAHEK---DILVE---R 892

Human   921 LEAKIKEVTER---AEDEEEINAE----LTAKKRKLEDECSELKKDI---DDLELTLAK----VE 971
            ..::::.|.||   .|::..|..|    |.|:|:.:|::.:..:.:|   .||..||.|    ::
pombe   893 ANSRVEVVHERLSSLENQVTIADEKYEFLYAEKQSIEEDLANKQTEISYLSDLSSTLEKKLSSIK 957

Human   972 KEKHATENKVKNLTEE----MAGLDETIAKLTKEKKALQEAH---------QQTLDD-----LQA 1018
            |::....:|.|.|.::    ||....:...|:..:||:.|.:         ...|||     .::
pombe   958 KDEQTISSKYKELEKDYLNIMADYQHSSQHLSNLEKAINEKNLNIRELNEKLMRLDDELLLKQRS 1022

Human  1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083
            .:.||..|.:....|:.|....|..|........:.|....|.|.:|.:.|:.|.:.   :.||.
pombe  1023 YDTKVQELREENASLKDQCRTYESQLASLVSKYSETESELNKKEAELVIFQKEITEY---RDQLH 1084

Human  1084 EKLK--KKEFEISNLQSK------------------IEDEQALGIQLQKKIKELQARIEELEEEI 1128
            :..:  :|...|::::|.                  ::|.|.|.....|:..:|..||:|:.|.:
pombe  1085 KAFQNPEKTHNINDVKSGPLNSDENIYSTSSTTLSILKDVQELKSLHTKEANQLSERIKEISEML 1149

Human  1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGA-------------TSAQIEMNKKREAEFQKM 1180
            |...|:..|..::.|:|...:|.:..::::....             |:..:|.|.....:||.:
pombe  1150 EQSIATEEKLRRKNSELCDIIEALKYQIQDQETEIISLNADNLDLKDTNGVLEKNASDFIDFQGI 1214

Human  1181 R------------------------------RDLEEATLQHEATAATLRKKHA-DSVAEL----- 1209
            :                              |.:.:.||...:...:..:||: |.:..:     
pombe  1215 KSRYEHKISDLLNQLQKERCKVGLLKQKTENRSVTQHTLDGNSPHPSFEEKHSGDPLKRIDGNND 1279

Human  1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK------AKGNLEKMCRTLEDQLSELKSK 1268
            ..:|||  ::.:.:.|....:::.:::..||:.::||      ..|::....|.||..||.|...
pombe  1280 DRKIDN--KLLKTISKSLDALQLTVEEELSNLYSLSKDLSFTDISGHIPNSIRKLEKGLSTLSEL 1342

Human  1269 EEEQQRLINDLTAQRGRLQTESGEFSRQL------DEKEALVSQLSR------GKQAFT------ 1315
            :|......:|..:......|::...||:|      |.:..|:|.|.:      ....||      
pombe  1343 KERLNASNSDRPSPDIFKDTQAIMNSRKLLSNPNSDAQSGLISSLQKKLYNPESNMEFTGLKPLS 1407

Human  1316 -------------------QQIEELKRQLEEE--------IKAKNALAHALQSSRHDCDL-LREQ 1352
                               .::|.|.|..::.        :..:|::   ||:.....:| |:|.
pombe  1408 PSKISNLPSSQPGSPSKRSGKMEALIRNFDQNSSIPDPFIVNQRNSV---LQTEFEKINLKLKEA 1469

Human  1353 -----YEEEQESK-AELQRALSKANTEVAQWRTK-------------YETDAIQRT--------E 1390
                 .:.:..|| :||.::|.|.|.|:....|.             ...|....|        |
pombe  1470 TKSGILDNKDLSKFSELIQSLLKENEELKNLTTSNLGSDDKMLDFAPLLEDVPNNTRNQIKGFVE 1534

Human  1391 ELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR-- 1453
            :...:|:.:|:...|:||       |..|.||..:.:..|.:.|:..::..:...:.|.....  
pombe  1535 KAISSKRAIAKLYSASEE-------KLFSTEKALREITKERDRLLHGLQGPSVPTSPLKAPTASQ 1592

Human  1454 ----NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIK------NAYEESLDQLETLKREN 1508
                |||..:..:..: |||    |..|:|     ..:.|||      |.|.|.|..:::|   |
pombe  1593 LIIPNFDGSITNYSGE-EET----EWLQEE-----VNIMKIKELTSTVNKYREQLAMVQSL---N 1644

Human  1509 KNLQQEISDLTEQIAEGGK-----RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568
            ::.:..:|.     ||..|     |:.|:|::.:..:....:||..|  |:|.::.:|.::|.: 
pombe  1645 EHAESSLSK-----AERSKNYLTGRLQEVEELARGFQTTNADLQNEL--ADAVVKQKEYEVLYV- 1701

Human  1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI 1633
                :..::.:..:.:|::.:.|:...|:..|:      |.|.|.:.|.: |.::.:.:||..::
pombe  1702 ----EKSNDYNTLLLQKEKLMKQIDEFHVIRVQ------DLEEREKKDQL-LFQRYQKELNGFKV 1755

Human  1634 QLNHANRMAAEALRNYRNTQGILKDTQIHLDD-ALRSQEDLKEQLAMVERRANLLQAEIEELRAT 1697
            ||...........::.|:....:.|.:...|: .|.....|||.        ::|||:::.|...
pombe  1756 QLEEEREKNLRIRQDNRHMHAEIGDIRTKFDELVLEKTNLLKEN--------SILQADLQSLSRV 1812

Human  1698 LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEK-- 1760
            ...:..:::.|:.:||..:.::|.:...|.:|              :.:.:.:|:|.||.|.|  
pombe  1813 NNSSSTAQQNAQSQLLSLTAQLQEVREANQTL--------------RKDQDTLLRENRNLERKLH 1863

Human  1761 ----------------------AKKAITDAAMMAEE------------------LKKEQDTSAH- 1784
                                  .|:.:|..:.:|::                  ||.::|::.| 
pombe  1864 EVSEQLNKKFDSSARPFDEIEMEKEVLTLKSNLAQKDDLLSSLVERIKQIEMFALKTQKDSNNHR 1928

Human  1785 -----LERMKKNMEQTVKDLQLRLDEAEQLALK----GGKKQIQKLEARVRELEGEVESEQKRNA 1840
                 |.|....:::..|||:|:|.:   |.||    ...|.::.|:.::.:||....:.   :.
pombe  1929 EENLQLHRQLGVLQKEKKDLELKLFD---LDLKTYPISTSKDVRMLQKQISDLEASFAAS---DI 1987

Human  1841 EAVKGL---RKHERRVKELTYQT---EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
            |.:||:   |..:|.:::|..|.   ::|:|   |:|..|.:|:.:....:.|.|:.:.......
pombe  1988 ERIKGIDECRNRDRTIRQLEAQISKFDDDKK---RIQSSVSRLEERNAQLRNQLEDVQASETQWK 2049

Human  1900 AKFRKLQHELEEAEERADIAESQVNKLR 1927
            ...|:.:|.|:|..||....|:..:|.|
pombe  2050 FALRRTEHALQEERERVKSLETDFDKYR 2077

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH2NP_001093582.1 Myosin_N 36..73 CDD:280832 14/37 (38%)
Myosin_head 88..772 CDD:278492 316/686 (46%)
MYSc_Myh2_mammals 100..772 CDD:276877 310/674 (46%)
Actin-binding. /evidence=ECO:0000250 661..683 14/21 (67%)
Actin-binding. /evidence=ECO:0000250 763..777 8/13 (62%)
Myosin_tail_1 852..1929 CDD:279860 261/1337 (20%)
RILP-like 967..1100 CDD:304877 33/174 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 3/31 (10%)
DUF342 <1672..1769 CDD:302792 21/120 (18%)
myp2NP_593816.1 COG5022 17..1607 CDD:227355 522/1638 (32%)
Myosin_N 38..76 CDD:280832 14/37 (38%)
MYSc_class_II 103..755 CDD:276951 310/674 (46%)
Tup_N 1684..1759 CDD:285748 18/88 (20%)
RILP-like <1997..2072 CDD:304877 19/77 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 654 1.000 Domainoid score I22
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 844 1.000 Inparanoid score I62
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - mtm10239
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.860

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