Protein Alignment SERPINC1 and nec

DIOPT Version :10

• Sequence 1: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_524851.1
• Gene: nec / 45908
• FlyBaseID: FBgn0002930
• Length: 476
• Species: Drosophila melanogaster
• Alignment Length: 418
• Identity: 97/418 - (23%)
• Similarity: 186/418 - (44%)
• Gaps: 59/418 - (14%)

Human    89 RFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHF 153
            ||::..::.:..|:: ..|:..||.|:....|:....:...|.::|.:..:|...:...:.....
  Fly   109 RFSSELFKEIIKSQS-QQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFES 172

Human   154 FFAKLNCRLYRKANKSSKLVSANRLFGDKSL-TFNETYQDISELVYGAKLQPLDFKENAEQSRAA 217
            ...      |:|..:.:.|..|.:::.::.| ..|.:|.:.::..:.|..:.:|. :||:.:.|.
  Fly   173 VIK------YKKHLEGADLTLATKVYYNRELGGVNHSYDEYAKFYFSAGTEAVDM-QNAKDTAAK 230

Human   218 INKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKVLRMALERPQGLPLALQLTPFFFKWRDR 282
            ||.||.:.|..:|.|::....::..|..:|||.:||
  Fly   231 INAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYF----------------------------- 266

Human   283 SPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE-GTQVLELP 346
                        ||.|:.:|:..:|....|...:|.....:||:.:..:....:.| |...|||.
  Fly   267 ------------QGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDDVYGLAELPELGATALELA 319

Human   347 FKGDDITMVLILPKPEKSLAKVEKELT-PEV-LQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQ 409
            :|....:|:::||.....|.|:.::|: ||. |......|....:.|.:|:|:.|....:.|.|:
  Fly   320 YKDSATSMLILLPNETTGLGKMLQQLSRPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLK 384

Human   410 DMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVT 474
            ::|:..:|:| .|::..::.:   .:.||....||::.|.|.|:||:|::.......||.|....
  Fly   385 NLGVHQMFTP-NSQVTKLMDQ---PVRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTE 445

Human   475 FKANRPFLVFIREVPLNTIIFMGRVANP 502
            |.||||| ||....|. :::|:|.|..|
  Fly   446 FVANRPF-VFAVRTPA-SVLFIGHVEYP 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	97/418 (23%)
nec	NP_524851.1	serpin42Dd-like_insects	105..471	CDD:381070	96/416 (23%)