DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPINC1 and Spn100A

DIOPT Version :9

Sequence 1:	NP_001373231.1	Gene:	SERPINC1 / 462	HGNCID:	775	Length:	505	Species:	Homo sapiens
Sequence 2:	NP_651818.1	Gene:	Spn100A / 43642	FlyBaseID:	FBgn0039795	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	85/384 - (22%)
Similarity:	151/384 - (39%)	Gaps:	116/384 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   182 KSLTFNETYQDISELVYGAKLQ---------------PLDFKENAEQSRA--------------- 216
            |:|..|||.|:..:|   ||:.               ||...|||.::.|
  Fly   301 KNLEENETVQEEEKL---AKIMAAPALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLALESHL 362

Human   217 ----AINKWVSNKTEGRITDVIPSEAI-----NELTVLVLVNTIYFKVLRMALERPQGLPLALQL 272
                .:|...|...:..||..:.:.:|     ...:.::|.|.:|:   |.:...|
  Fly   363 PSVSRVNGARSLFQQDDITSALSANSITGRSAGSKSKMLLFNGLYY---RGSWANP--------- 415

Human   273 TPFFFKWRDRSPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVA 337
               |::.||.|                         .|.|:..:.::..|.||:..|||   :||
  Fly   416 ---FYQLRDGS-------------------------DEFFFMTNEDAVKAPMMHARGKF---QVA 449

Human   338 EGTQ----VLELPFKGDDITMVLILPKPEKSLAKVEKEL-TPEVL----QEWLDELEEMMLVVHM 393
            :..|    ||.||::.....:.::||...:.|:.|..:| |.:.|    |..:.||.     :.|
  Fly   450 DLPQVKARVLSLPYETSRYALCIVLPDETEGLSDVISQLQTSDFLLAKKQFQMKELH-----ISM 509

Human   394 PRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAAS 458
            |:|::|:....:..|:.|||..:||..:::| .:::|. .|::|.:......:.|:|.||.|.:.
  Fly   510 PKFQVEETSRSEAMLKQMGLKKVFSRTEAQL-SLLSED-PDVHVDEIVQFVNVRVDEGGSSANSL 572

Human   459 TAVVIAGRSLN---------------PNRVTFKANRPFLVFIREVPLNTIIFMGRVANP 502
            :|..:..|:.:               |....|:.||||..||.:.....::..|::..|
  Fly   573 SAATMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFIVDCQEQFVLASGKIYTP 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	85/384 (22%)
Spn100A	NP_651818.1	SERPIN	41..>148	CDD:294093
Spn100A	NP_651818.1	SERPIN	<380..628	CDD:294093	67/297 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010