Protein Alignment SERPINC1 and Spn77Bc

DIOPT Version :10

• Sequence 1: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_649207.1
• Gene: Spn77Bc / 40236
• FlyBaseID: FBgn0036970
• Length: 416
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 107/459 - (23%)
• Similarity: 171/459 - (37%)
• Gaps: 113/459 - (24%)

Human    76 TNRRVWELSKANSRFATTFYQ----HLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLME 136
            |...:.:::.|..:||....|    ||     :.:|..::|.|..:...|...||...||:|:.:
  Fly    26 TKSLLQKMTDARLQFALNLLQMESTHL-----NLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRD 85

Human   137 VF----KFDTISEKTSDQIHFFFAKLNCRLYRKAN-KSSKLVSANRLFGDKSLTFNETYQDIS-- 194
            |.    .:.|:.....|          .|.|...| :::||.|....:          |.|:.
  Fly    86 VLAIYVDYPTLRRWYED----------VRAYHYLNSENTKLFSLRYAY----------YDDVGDL 130

Human   195 ELVYG------------------AKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINE 241
            |||.|                  .:.:.:||.:.|.   ..||..:...:..:|.......:.|.
  Fly   131 ELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQGAS---IIINDDIDKASHAKIFSSYSRRSFNS 192

Human   242 LTVLVLVNTIYFKVLRMALERPQGLPLALQLTPFFFKWRDRSPERANGLPKATQGLWKSKFSPEN 306
            ...::.:...|||                                         ..||..|....
  Fly   193 TVTVLGITVSYFK-----------------------------------------AKWKYPFDKSQ 216

Human   307 TRKELFYKADGESC-SASMMYQEGKFRYRRVAEGTQ--VLELPFKGDDITMVLILPKPEKSLAKV 368
            |:.|.||.|.|... ...||.|.||:.|....:|.|  ||||||...::.|::|||||.:.::.|
  Fly   217 TKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVILPKPSQRVSLV 281

Human   369 EKELTPEVLQEWLDELE----EMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVA 429
            .|:|....|...|:|||    |..:.|.:|:|......||::.:.:.||.||.:........::.
  Fly   282 LKQLKNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRNEFADLGRMLIP 346

Human   430 EGRDDLYVSDAFHK-AFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTI 493
            .|....|:| .:|: |.:.|:|||...|      :..:|...|.:.|..||||...:.:.....:
  Fly   347 TGDRGAYLS-LYHQFARIVVDEEGLPNA------VPQKSSGTNNIKFHINRPFAYLVLQRTHKLL 404

Human   494 IFMG 497
            |..|
  Fly   405 IHSG 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	107/459 (23%)
Spn77Bc	NP_649207.1	serpin	33..412	CDD:476815	106/452 (23%)