Protein Alignment SERPINC1 and Spn43Ad

DIOPT Version :10

• Sequence 1: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_610261.1
• Gene: Spn43Ad / 35639
• FlyBaseID: FBgn0044011
• Length: 407
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 106/519 - (20%)
• Similarity: 182/519 - (35%)
• Gaps: 153/519 - (29%)

Human    18 LLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWE 82
            |||.||:|....:|               :|::...:.|||
  Fly     6 LLSALLVGLAIALT---------------LPVDGELLARSP------------------------ 31

Human    83 LSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACND---TLQQLME-------- 136
            .|.:::||.......|..::.| .|:.:|||.|..|.::....:.::   .|:|.:|
  Fly    32 ASVSSNRFGLRLTTKLGLTQPD-ANVVVSPLLIQAALSLLYAESSSEYGSQLRQALELTHASHPK 95

Human   137 --VFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYG 199
              |..|:|:.......     |.:.|||        :|:|  .|:..:..|||
  Fly    96 LAVQDFETLLTDLKQS-----AAIGCRL--------RLLS--DLYAQQRFTFN------------ 133

Human   200 AKLQPLDFKENAEQSRAAIN------KWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKVLRM 258
                   |:...|...|.:.      .|.|           .|.|..::....|..:.:  .|..
  Fly   134 -------FRNEFETLAARMGVGCHRLSWES-----------ASNAAQDINYAFLSRSNF--SLGE 178

Human   259 ALERPQGLPLALQLTPFFFKWRDRSPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSAS 323
            .:..||...||...|||.         ..:|:  ..:..|...|.|..|:...|:..........
  Fly   179 LVSAPQLESLAEHNTPFL---------HVSGV--TFRAPWAWAFDPTETQSINFFAGGNRPRLVD 232

Human   324 MMYQEGKFRYRRV-AEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEM 387
            .|:.:.::||..| |...|::|:||...|:.|:::.|.....||::|::|....|.:...:|||.
  Fly   233 AMFGQHRYRYAEVPALDAQLIEVPFATADLRMLIVFPNRPDGLAQLERKLAQSDLHQLRSQLEER 297

Human   388 MLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAF----------- 441
            .:.:.:|:.|:.....||..|:::||..||:.|              :::|:.|
  Fly   298 KVALTLPKLRVLVHSDLKHVLEELGLAKLFTSE--------------VHLSEVFSSILSSSAPPL 348

Human   442 ----HKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVAN 501
                ....||:.|:|..|..|.:.....|...|    ...|.||...|...  .|::..|.:.:
  Fly   349 GAVVQSGLLELQEDGGNADDSFSFGDLFRRALP----LVINHPFFYAIGNG--KTLLLSGHIVD 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	95/467 (20%)
Spn43Ad	NP_610261.1	serpin42Dd-like_insects	34..407	CDD:381070	94/452 (21%)