DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERPINC1 and CG43366

DIOPT Version :9

Sequence 1:	NP_001373231.1	Gene:	SERPINC1 / 462	HGNCID:	775	Length:	505	Species:	Homo sapiens
Sequence 2:	NP_610188.2	Gene:	CG43366 / 35519	FlyBaseID:	FBgn0263109	Length:	2140	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	98/545 - (17%)
Similarity:	192/545 - (35%)	Gaps:	156/545 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    51 PMCIYRSPEKKATEDEGSEQKIPEAT---NRRVWELSKANSRFATTFYQHLADSK-NDNDNIFLS 111
            |:.:..|||        |.|.:..:|   :..:...::..:..|.::::.:...| :...::.:|
  Fly  1655 PVKLDPSPE--------SSQGLEASTAMMDEDLQSFARLCNELAFSYWRAITSEKISSARSLVIS 1711

Human   112 PLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSA- 175
            |.::::..:|..|||...|..::.|:.|.|   :..:...|..|..:. ....:|:.|....:|
  Fly  1712 PFALTSMLSMVFLGARGSTSGEMNEILKLD---DMVTFNPHLIFKNIT-NSVEQASDSDIATAAF 1772

Human   176 -NRLFGD----KSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIP 235
             ..:|.|    |.|.|   :::.::.:|...::.::|....:..|...|..|...|.|::.:.:.
  Fly  1773 VREIFSDRANGKILPF---FKEKTQQLYAGHVEEVNFHVVNDIVRRRTNLLVKRHTMGKVLEYLR 1834

Human   236 SEAINELTVLVLVNTIYFKVLRMALERPQGLPLALQLTPFFFKWRDRSPERANGLPKAT--QGLW 298
            :.::                                       |       .|| |.||  ..|:
  Fly  1835 TNSV---------------------------------------W-------VNG-PLATISANLF 1852

Human   299 KSKFSPENTRK---ELFYKADGESCS------ASMMYQEGKFRYRRVAEGTQVLELPFKGDDITM 354
            ::..|..:|..   |:|::.......      .:::|:.|.......:....|:......:.::.
  Fly  1853 QTDCSHGSTTDRDGEMFFQVHPTVRQRRLVPIPAVLYRSGFLAGYEPSLDATVVSFGRVQNTVST 1917

Human   355 VLILP------KPEKSLAKVEKELTPEVL---QEWLDELEEMM----LVVHMPRFRIEDGFSLKE 406
            |.::|      .|..:|.::|:.|.....   |.|...|..:|    :.|.:|||......:...
  Fly  1918 VYVMPGHQSSISPMDNLDRLERSLVETAFSDKQAWRRLLTSLMDRPGMEVQLPRFSHRSFVNASL 1982

Human   407 QLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSD---------------------------AFHKA 444
            .||.|||..||..:.:.|.|:...|..|:::||                           ...|.
  Fly  1983 GLQKMGLRGLFKSDFADLRGLTGAGNRDIFLSDMIQINTFSTCGEEKISEHHHVEMYPAPPLRKR 2047

Human   445 FLEVNEEGSEAAASTAVVI----------AGRSLN----------------------PNRVTFKA 477
            ..:|:....:|..|:..|:          .||...                      |:....:.
  Fly  2048 NKDVDATDDDAFDSSERVVDFGSLVQESALGRGFYDDLLDPKYLELPLPLRPRQARVPDAPRLRF 2112

Human   478 NRPFLVFIREVPLNTIIFMGRVANP 502
            ::|||.|:|..|...|:||||. ||
  Fly  2113 DKPFLYFVRHNPTGMILFMGRF-NP 2136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	93/526 (18%)
CG43366	NP_610188.2	SERPIN	1687..2136	CDD:294093	89/503 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100