Protein Alignment SERPINC1 and Spn28Dc

DIOPT Version :10

• Sequence 1: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_609172.1
• Gene: Spn28Dc / 34091
• FlyBaseID: FBgn0031973
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 125/485 - (25%)
• Similarity: 200/485 - (41%)
• Gaps: 112/485 - (23%)

Human    75 ATNRRVWELSKANS--RFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEV 137
            ||:.|:     |||  .||....||||:.|..    ..|||||..:.|:..|||...:.::|..|
  Fly   103 ATSDRI-----ANSVLNFANILGQHLANGKTQ----IYSPLSIVHSLALLLLGAKGRSYEELSTV 158

Human   138 FKF-DT-------------ISEKTSDQIHF------FFAKLNCRLYRKANK--SSKLVSANRLFG 180
            |.. ||             :.:.|.:.|..      :.|....|..|:|.:  :.::..||.||.
  Fly   159 FDIPDTSRLHEQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFT 223

Human   181 DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVL 245
            ....|.|..|:.:...||.:.||..||:.:...:|..||.:|:..|:..|.::|.|: |.:.|.:
  Fly   224 QTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASD-IPQTTRM 287

Human   246 VLVNTIYFKVLRMALERPQGLPLALQLTPFFFKWRDRSPERANGLPKATQGLWKSKFSPENTRKE 310
            :|.|.:|||                                         ..|::.|....||.:
  Fly   288 ILANALYFK-----------------------------------------AFWETDFIESATRPD 311

Human   311 LFYKADGESCS----ASMMYQEGKFRYRRVAE-GTQVLELPFKGDDITMVLILP--KPEKSLAKV 368
            .|| .:||...    ..||...|.:.|....| |.:::.||::|:..||.:|.|  ...:.|..:
  Fly   312 NFY-PNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYIIQPFKSSVRELMAL 375

Human   369 EKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAE--- 430
            :|.||.:.::..:..:.....:|..|:..:.:..:||..:|.|||..:||..::.|..|...
  Fly   376 QKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEAT 440

Human   431 -----------------------GRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNR 472
                                   .|.||.|.|..||....|||:|:|||||:...:  :...|:
  Fly   441 RTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASSVTYL--KKSGPD- 502

Human   473 VTFKANRPFLVFIREVPLNTIIFMGRVANP 502
            |.|:.:.||:|.:|..|...::|.|.:..|
  Fly   503 VLFRGDTPFMVLVRHDPTKLVLFYGLINEP 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	125/485 (26%)
Spn28Dc	NP_609172.1	serpin28D-like_insects	111..532	CDD:381061	119/470 (25%)