Protein Alignment Spn and Ppp1r9b

DIOPT Version :10

• Sequence 1: NP_001246578.1
• Gene: Spn / 46194
• FlyBaseID: FBgn0010905
• Length: 2148
• Species: Drosophila melanogaster
• Sequence 2: NP_758465.2
• Gene: Ppp1r9b / 217124
• MGIID: 2387581
• Length: 817
• Species: Mus musculus
• Alignment Length: 68
• Identity: 19/68 - (27%)
• Similarity: 29/68 - (42%)
• Gaps: 12/68 - (17%)

  Fly   106 QECVTNDGKFINNEFNDVYL-----VTILH----PIPLEAFTLQKEEVSAVKYVPYEEYRNFLSK 161
            ||.::..|:.....|.. ||     |...|    |....|:..::|:::....|||  |.||..|
Mouse   192 QEVISTIGQAFELRFKQ-YLKNPPKVVTPHDRMAPFDGSAWEEEEEDLAPPPEVPY--YNNFPGK 253

  Fly   162 EDP 164
            :.|
Mouse   254 QPP 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn	NP_001246578.1	PDZ_5	1182..1254	CDD:465518
		PDZ_neurabin-like	1258..1347	CDD:467252
		SMC_N	<1344..1606	CDD:481474
		CENP-F_leu_zip	1424..1535	CDD:463102
		SAM_Neurabin-like	2050..2118	CDD:188911
Ppp1r9b	NP_758465.2	Actin-binding. /evidence=ECO:0000250	1..154
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..163
		Interaction with D(2) dopamine receptor. /evidence=ECO:0000250	100..371		19/68 (28%)
		Actin-binding. /evidence=ECO:0000250	164..282		19/68 (28%)
		Interaction with ADRA2A, ADRA2B and ADRA2C. /evidence=ECO:0000250	169..255		18/65 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..451		13/43 (30%)
		Interaction with protein phosphatase 1. /evidence=ECO:0000250	417..494
		PDZ_5	426..489	CDD:465518
		PP1-binding motif. /evidence=ECO:0000250|UniProtKB:O35274	447..451
		Interaction with RGS2. /evidence=ECO:0000250	480..525
		PDZ_neurabin-like	493..582	CDD:467252
		Interaction with TGN38. /evidence=ECO:0000250	595..816
		YhaN	664..>813	CDD:443752