Protein Alignment Spn and SAMD14

DIOPT Version :10

• Sequence 1: NP_001246578.1
• Gene: Spn / 46194
• FlyBaseID: FBgn0010905
• Length: 2148
• Species: Drosophila melanogaster
• Sequence 2: XP_016879811.1
• Gene: SAMD14 / 201191
• HGNCID: 27312
• Length: 500
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 132/544 - (24%)
• Similarity: 193/544 - (35%)
• Gaps: 168/544 - (30%)

  Fly  1630 DELDAAVPQHELLDNSINKTKIDLASRGGLANRQLPSANGNSSTSNGAAVDLGQLSNGNLLKRSR 1694
            ::||.|||:...||:|::|.:..|.::|   .|..|                           ||
Human    97 EDLDLAVPETARLDSSLHKARAQLLAKG---RRHRP---------------------------SR 131

  Fly  1695 SNSRSSDCTLDDTDEEEEREGSALNLAGAPV------AHETISLSNGNSHLLANVNNLLQHHPPA 1753
            |..|.|..:.:|.:..:...|...:..|:|:      .|.......|.|..|         .||.
Human   132 SRLRDSASSAEDGEGSDGPGGKVTDGCGSPLHRLRSPLHSGPGSPAGGSFCL---------DPPG 187

  Fly  1754 MATVI--ATPSNGHLGTTTPILLNSTSSASSSSSNQSTAREAQINQLYAQ-VHKDPSKQQHQQQQ 1815
            :...:  ..|....|....| |.|:.|....::::.|..|.|..:..... |.:.|..:.|  .:
Human   188 LRRSLDEDEPPPSPLTRYRP-LHNAASHEGLAAASCSPPRSAPSSDSSPSFVRRHPRAEPH--SE 249

  Fly  1816 QQQQQAQAVTTSIPSIFKNALGSPADNGLNDFHRGSMTTFG-------TGPA---TSSNRDLNSS 1870
            ...:.|.....:.|:|           ||:...|......|       ||.:   ..|||....|
Human   250 DDSRDASPPEPASPTI-----------GLDKKTRRKFLDLGVTLRRASTGKSRKEKGSNRLSMGS 303

  Fly  1871 YDSILGSNDKLAENDPAESWMYPSRRRVAPNGSKVPLPGSSFTDQLNQALSDRERRLGDGSSRHS 1935
            .:|:.||                     ..:|....||.|.|||.            |.||:
Human   304 RESVEGS---------------------GRSGGSPFLPFSWFTDS------------GKGSA--- 332

  Fly  1936 SDDYTEINKSQSAAAINCKTLINEIRQAVNEAQPKVKQVVP-QSLSPPGTVPWQQQHHQQIQQQP 1999
                    .|.|..:..|              .||.:...| :|.|...|:
Human   333 --------SSGSTTSPTC--------------SPKHEGFSPKKSASQESTL-------------- 361

  Fly  2000 SAHTTGPPSPTSMSSG------CSSPGYSPSRTLDLSGSSSSFSDRKAMAAGYTYKGGPVHEWTK 2058
            |..:|.|.|...:.||      ||.|.::      ||.||..|.|...         .|||.||.
Human   362 SDDSTPPSSSPKIPSGPWQEAKCSYPYHT------LSQSSDEFLDEPL---------PPVHHWTS 411

  Fly  2059 DQVGHWLMGIELERYIPVFKENNVEGGALLTLDSKDFKTLGICGD-DKHRLKKRLKDLKANIEKE 2122
            .|||.||..:.||:|...|....|:|..||.||....|:||:... |:..:|::||::.|..|||
Human   412 QQVGQWLQSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKEMAAAAEKE 476

  Fly  2123 RKDMERERREREKAIRKAEKKAAK 2146
            ||..|:..|:||| :|:.|::|.|
Human   477 RKAQEKAARQREK-LRRREQEAKK 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn	NP_001246578.1	PDZ_5	1182..1254	CDD:465518
		PDZ_neurabin-like	1258..1347	CDD:467252
		SMC_N	<1344..1606	CDD:481474
		CENP-F_leu_zip	1424..1535	CDD:463102
		SAM_Neurabin-like	2050..2118	CDD:188911	27/68 (40%)
SAMD14	XP_016879811.1	SAM_Neurabin-like	404..469	CDD:188911	27/64 (42%)