Protein Alignment MYH1 and Prm

DIOPT Version :10

• Sequence 1: NP_005954.3
• Gene: MYH1 / 4619
• HGNCID: 7567
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Alignment Length: 819
• Identity: 295/819 - (36%)
• Similarity: 494/819 - (60%)
• Gaps: 1/819 - (0%)

Human  1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176
            :..|:.:|..|::::|.||..|.:.|::::|||.::.::|||||||.|....|.|.|:||:||..
  Fly    37 LSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELL 101

Human  1177 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET 1241
            |:|:.||:..|:.|.|...|:|||.:.:.:..||::.|.:.|.:.||:|::.:.|:.:|.|.:|:
  Fly   102 KLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIES 166

Human  1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS 1306
            .:|.|...||....||..:||:..|.||..|.:.|:::.|:||..|:.|.::.:.:....:..:|
  Fly   167 YNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTVS 231

Human  1307 RGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSE 1371
            ..|.....|:|:.:|:||:|.:.:|.|..:|.....:.|.:|.|.|||.||:.:|:|.:.|||::
  Fly   232 FSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANAD 296

Human  1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV 1436
            ...|:.|:.::...|.||:||.::|...|:.:.|||:|::..|..:|||.|.||.:|||.|:||:
  Fly   297 ATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDL 361

Human  1437 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLET 1501
            |::|.:|..|.|.....:|...|.|.:.:||....|.||::.::...:|.:..:..::..|....
  Fly   362 EKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNNQ 426

Human  1502 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566
            |.||||.|..::.:....|.|..:|:||||...:::|.|:.||.||.:||||..:.||.:..|:.
  Fly   427 LTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRLA 491

Human  1567 LELNQVKSEVDRKIAEKDEEIDQM-KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1630
            .:.||.:.:.:|::|||||||:.: |:..|.|.:.....::||.|.:.:..|:|||::..:.|:|
  Fly   492 ADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELE 556

Human  1631 IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRAT 1695
            :.|:.||:...:..:..:.....|.:.|.|.:|..|..:...:|.|:.:||...|..|:||:|:.
  Fly   557 MSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSH 621

Human  1696 LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAK 1760
            |:...|:::..|.:..:|:.|:..|.|.|.||::.|.|||.::|.:..:.|::.:|.|.::|:.:
  Fly   622 LDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQ 686

Human  1761 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRE 1825
            |...:...:.|::.:||:....||.:||:||..||:|..||:|.|..|:.|.|:.|.|||||:|:
  Fly   687 KVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRD 751

Human  1826 LEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890
            ||.|:|.|::|:.|.:|.|||.||.|||:..|.|||:||::.|||.:||..||:..|:||..|.|
  Fly   752 LELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQE 816

Human  1891 EQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSR 1929
            ..|....::.||.|.|||.||:|||.|||.:|.:|.|.|
  Fly   817 GVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH1	NP_005954.3	Myosin_N	33..77	CDD:460670
		MYSc_Myh1_mammals	100..770	CDD:276875
		Actin-binding. /evidence=ECO:0000250	659..681
		Actin-binding. /evidence=ECO:0000250	761..775
		Myosin_tail_1	850..1927	CDD:460256	293/815 (36%)
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	293/815 (36%)