DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH1 and ck

DIOPT Version :9

Sequence 1:NP_005954.3 Gene:MYH1 / 4619 HGNCID:7567 Length:1939 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2233 Identity:560/2233 - (25%)
Similarity:907/2233 - (40%) Gaps:552/2233 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    27 AQNKPFDAKTSVFVVDPKESFVKATVQSREGGKVTAKTEAGATVTVKDD-QVFPMNPPKYDKIED 90
            |..:.||..            :.|.|.|.||.::..:.:.|..|.:..: ::..|:......:||
  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67

Human    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHI 155
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132

Human   156 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEVTSGKMQGTLE 220
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|            ||| ...:|
  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI------------SGK-HSWIE 184

Human   221 DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERS 285
            .||:.|||:|||||||||:||||||||||:|.|||...|.:..|.||.|||||||:..|..:||:
  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249

Human   286 YHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQG-EITVPSIDDQEELMATDSAIEILGFTSDER 349
            ||:||.|::....|....|.:.. ..||.:::.| .||....||..|.....||:::|.|:..|.
  Fly   250 YHVFYCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEI 313

Human   350 VSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLQNLNSADLLKALCYPRVKV 409
            ..|.||..|::|.||:|:|....:..   |.||:     .::.|.|..|....|:.||....:..
  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA 375

Human   410 GNEYVTKGQTVQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPR---QYFIGVLDIAGFEIF 471
            ..|.|....:..|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.|||.|
  Fly   376 HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIFGFENF 438

Human   472 DFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPMGIFS 535
            |.||.||.|||:.||.|||||..|:|.||||||..|.|.|..|:| :|....::||. |.:.|.:
  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMA 502

Human   536 ILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLIHYAGTVDYNIAGWLDKN 600
            :::||..|||.||.:...||::.| |...|:.||   |......|.|.|:||.|.|:..|:||||
  Fly   503 LIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKN 563

Human   601 KDPLNETVVGLYQKSAMKTLALLFVG--ATGAEAEAGGGKKGGKKKGSSFQTVSALFRENLNKLM 663
            :|..:..::.|..:|..|.|..:|..  ..|||.         :|:   ..|:|..||::|:.||
  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAET---------RKR---TPTLSTQFRKSLDALM 616

Human   664 TNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKV 728
            ..|.|..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|.:||:.
  Fly   617 KTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRF 681

Human   729 LNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLITRTQ 793
            | ...:|.....|.:.|:.::. ::.:..:.|:.||||||.|......||:.||..|.:.|...|
  Fly   682 L-IPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQ 744

Human   794 AMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKL-YFKIKPLLKSAETEKEMANMK 857
            ...||::.|   ::.:..|.:...:|...:.:...|.:..|:: |.:::.|::|..       :.
  Fly   745 RSIRGWVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRV-------LS 799

Human   858 EEFEKTKEELAKTEAK------RKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTK 916
            ..|...:..:...:|.      |:|...||..:::.::.::..:         |..|     ..|
  Fly   800 HRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR-----YRK 850

Human   917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981
            ::||.|     :.||         ..:.||||::  ||..            ...|||.|...::
  Fly   851 LRLEHK-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAREIAEQH 887

Human   982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD---LEGSLE 1043
            ..:.:..|         |::.:||    .|::.:..|..:|.:..|..|.|:.|||   :|...:
  Fly   888 YRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFD 939

Human  1044 ---------------QEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG 1093
                           :|..:..||..|:...:.|:    .:.:.|..|::.|.| .|.::|..:.
  Fly   940 FLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDI----IAPIHISEDEEDLSE-FKFQKFAATY 999

Human  1094 LQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
            .|..:..:.|     :|.:|.....:....:::.|: |......:...|:........:|::...
  Fly  1000 FQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTS 1058

Human  1159 --GATSAQIEMNKKREAEFQK---MRRD------LEEATLQHEATAATLRKKHADSVAELGEQI- 1211
              ...:|.:..|..|..|||:   |..|      .:..:::|:..:.||::|:     :|||.: 
  Fly  1059 VMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGEDVR 1118

Human  1212 ----------DNLQ-----RVKQKLEK---------EKSEMKMEI-----DDLASNMETVSKAKG 1247
                      |:.|     |....|||         .::|::.||     ..|.:|....|.|:|
  Fly  1119 RRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARG 1183

Human  1248 NL------------EKMCRALEDQLSE-----IKTKEEEQQRLINDLTAQR----ARLQTESGEY 1291
            .:            ||....|...:.|     ....||..:|..|:.|..:    ..||....:.
  Fly  1184 WILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKK 1248

Human  1292 SRQL-------DEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHAL------------ 1337
            ...|       :.|..|....:..:        ||..||.::|..|.....:|            
  Fly  1249 PIMLPITFMDGNTKTLLADSATTAR--------ELCNQLSDKISLKDQFGFSLYIALFDKVSSLG 1305

Human  1338 QSSRHDCDLLR--EQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEE----------- 1389
            ....|..|.:.  |||.:||.|:           ...|.||..:..:......|           
  Fly  1306 SGGDHVMDAISQCEQYAKEQGAQ-----------ERNAPWRLFFRKEIFAPWHEPTHDQVATNLI 1359

Human  1390 LEEAKK--KLAQRLQDAEEHVEAVNAK--------CASLEKTKQRLQNEVEDLMID-----VERT 1439
            .::..:  |..:...|.||.:..:.|:        ..|:|:....|.|.:.|..:.     :||.
  Fly  1360 YQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERW 1424

Human  1440 NAACAALDKKQ-----------------------------------RNF-------DKILA-EWK 1461
            .|......||.                                   ||.       |.|:| .|.
  Fly  1425 AALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWT 1489

Human  1462 -----QKCEETHAELE-------ASQKESR------SLST---ELFKIKNAYEESLDQ-----LE 1500
                 ...|:...||.       :|||.::      ||||   |.|..::...|.:..     |:
  Fly  1490 GVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLD 1554

Human  1501 TLKRENKNL-----QQEISDLTEQIA--EGGKRIHELEKIKKQV------------EQEKSELQA 1546
            .||:.:|.:     .:..||.|..::  :|...|.|.|...:.|            .||:.:..|
  Fly  1555 GLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPA 1619

Human  1547 A--------------------LEEA-------------------------EASLEHEEGKILRIQ 1566
            .                    :|||                         |.:|:|       .:
  Fly  1620 ETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDH-------FR 1677

Human  1567 LELNQVKSEVDRKIAEKDEEIDQMKRNHIR--IVESMQS----------TLDAEIRSRNDAIRLK 1619
            |...:..|:.....:::.||:.:..|:.|:  ::..:||          ...|.::...|....:
  Fly  1678 LPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKR 1742

Human  1620 KKMEGDL---------------NEMEIQL-----NHANRMAAE--------ALRNYRNTQAILKD 1656
            .:|..::               :|:..||     ::.|||:.|        |...:..:|.:||:
  Fly  1743 PRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKE 1807

Human  1657 TQLHL---------DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ----------TERS 1702
            ..|.|         |...|.|:.::..    :|:....|.|:|.::....|          |:.:
  Fly  1808 LLLFLRTRRHPISQDSMHRLQKTIRHG----QRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEA 1868

Human  1703 RKI-----AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE--------MEDIIQEARN 1754
            .::     |:....:.|:|:.|..::..||.  .|..:..||..:|:        :.|.|::||.
  Fly  1869 FEVDSSTRAKDFCNNISQRLSLRTSEGFSLF--VKIADKVISVPEGDFFFDFVRHLTDWIKKARP 1931

Human  1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV--KD-----LQHRLDEAEQLALKGG 1812
            ..:.|....|.....                |||....||  ||     :.|...|..:| |:|.
  Fly  1932 IRDGANPQFTYQVFF----------------MKKLWTNTVPGKDRNADLIFHYHQELPKL-LRGY 1979

Human  1813 KKQIQKLEARVRELEGEVE-SEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQ 1876
            .|..::..|::..|...|. .|.|:.::|:      .:.::||.      ..:|:::|...:..:
  Fly  1980 HKCSREEAAKLAALVFRVRFGENKQELQAI------PQMLRELI------PSDIMKIQSTSEWKR 2032

Human  1877 AKVKSYKRQAEEAEEQSNVNLSK 1899
            :.|.||.:......|.:.|...|
  Fly  2033 SIVASYNQDGGMTSEDAKVAFLK 2055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH1NP_005954.3 Myosin_N 36..73 CDD:280832 7/36 (19%)
Myosin_head 88..770 CDD:278492 279/693 (40%)
MYSc_Myh1_mammals 100..770 CDD:276875 273/681 (40%)
Actin-binding. /evidence=ECO:0000250 659..681 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 761..775 7/13 (54%)
Myosin_tail_1 850..1927 CDD:279860 252/1396 (18%)
RILP-like 965..1098 CDD:304877 30/150 (20%)
MIT_CorA-like <1299..>1411 CDD:294313 24/138 (17%)
DUF342 <1506..1582 CDD:302792 20/139 (14%)
DUF342 <1670..1767 CDD:302792 22/119 (18%)
TMPIT 1744..>1853 CDD:285135 25/124 (20%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 282/706 (40%)
MYSc_Myo7 77..721 CDD:276832 273/681 (40%)
MyTH4 <1138..1245 CDD:214535 23/106 (22%)
B41 1251..1467 CDD:214604 37/234 (16%)
FERM_B-lobe 1355..1439 CDD:271216 15/83 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/97 (23%)
SH3 1560..1624 CDD:302595 12/63 (19%)
MyTH4 1701..1849 CDD:214535 27/151 (18%)
B41 1856..2068 CDD:214604 46/231 (20%)
FERM_M 1966..2068 CDD:278785 22/103 (21%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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