DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH1 and myo-3

DIOPT Version :9

Sequence 1:NP_005954.3 Gene:MYH1 / 4619 HGNCID:7567 Length:1939 Species:Homo sapiens
Sequence 2:NP_506065.2 Gene:myo-3 / 179676 WormBaseID:WBGene00003515 Length:1969 Species:Caenorhabditis elegans


Alignment Length:1927 Identity:941/1927 - (48%)
Similarity:1353/1927 - (70%) Gaps:15/1927 - (0%)


- Green bases have known domain annotations that are detailed below.


Human    15 PFLRKSERERIEAQNKPFDAKTSVFVVDPKESFVKATVQSREGGKVTAKTEAGATVTVKDDQVFP 79
            |||..|...|.....:|||:|.:.::.||::.||.|.:||..|.:||..|..|..:|||.||...
 Worm    15 PFLGISREARAATAARPFDSKKNCWIPDPEDGFVAAEIQSTTGEQVTVVTVKGNQITVKKDQCQE 79

Human    80 MNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYR 144
            |||||:||.||||.:|.|:|.:||.|||:||...|||||||||||.:||||.||:|:..|:..:.
 Worm    80 MNPPKFDKTEDMANLTFLNEASVLGNLKDRYKDLMIYTYSGLFCVVINPYKRLPIYSESVIKHFM 144

Human   145 GKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEE 209
            ||:|.|.|||:|::||.||:.|:.|:||||:|||||||||||.|||:||.|||.:..|.....:|
 Worm   145 GKRRNEMPPHLFAVSDEAYRNMVQDKENQSMLITGESGAGKTENTKKVISYFAIVGATQAASGKE 209

Human   210 VTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKS 274
            ...||..||||:||:..||:||||||||||||:||||||||||.||..:||||..|||.||||||
 Worm   210 AKDGKKGGTLEEQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRTHFSGSGKLAGGDIEHYLLEKS 274

Human   275 RVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAI 339
            ||..|...||.|||||||||...|.|...|.::.:...|.|.||.|:|:..:||:||:..|..|.
 Worm   275 RVVRQAPGERCYHIFYQIMSGNDPSLRGKLKLSNDITYYHFCSQAELTIEGMDDKEEMRLTQEAF 339

Human   340 EILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCY 404
            :|:||..:|.:.:|:.|..:||.|.|||||:.|||||||||.|.|..||.:..:.:.:.||||..
 Worm   340 DIMGFEDNETMDLYRSTAGIMHMGEMKFKQRPREEQAEPDGEEDALNAAAMLGIQAEEFLKALTK 404

Human   405 PRVKVGNEYVTKGQTVQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQ-PRQYFIGVLDIAGF 468
            |||:||.|:|.|||.::||..||..||||:|.:||.|::||.|:.||.|: .|::||||||||||
 Worm   405 PRVRVGTEWVNKGQNLEQVNWAVSGLAKAIYARMFKWIITRCNKTLDAKEIERKHFIGVLDIAGF 469

Human   469 EIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGI 533
            ||||.||.|||.|||.||:||||||||||||||||||:|||.|||||||:||.|||||||||:||
 Worm   470 EIFDLNSFEQLWINFVNERLQQFFNHHMFVLEQEEYKREGIAWTFIDFGLDLQACIELIEKPLGI 534

Human   534 FSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKP-EAHFSLIHYAGTVDYNIAGWL 597
            .|||:|||:.|||||.::..||.:|||||..|||||||.|||. :|||:::||||||.||...:|
 Worm   535 ISILDEECIVPKATDMTYAQKLLDQHLGKHPNFQKPKPPKGKQGDAHFAIVHYAGTVRYNATNFL 599

Human   598 DKNKDPLNETVVGLYQKSAMKTLAL-----LFVGATGAEAEAGGGKKGGKK-KGSSFQTVSALFR 656
            :|||||||:|.|.|.:.|...:|.|     .......|||...|...|||: |.|||.|||.::|
 Worm   600 EKNKDPLNDTAVALLKHSTDNSLMLDIWQDYQTQEEAAEAAKAGQTAGGKRGKSSSFATVSMIYR 664

Human   657 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYAD 721
            |:||.||..|..|||||:|||||||.|..|.::..|||:||.||||||||||||||||:|:||.|
 Worm   665 ESLNNLMNMLYQTHPHFIRCIIPNEKKASGVIDSALVLNQLTCNGVLEGIRICRKGFPNRMLYPD 729

Human   722 FKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDID----HTQYKFGHTKVFFKAGLLGLLEEMRD 782
            ||.||.:|.|.|..|.   |.||||..:|..|.:|    ..::|.|.||:|||||:|..||::||
 Worm   730 FKHRYAILAADAAKES---DPKKASVGILDKISVDGNLTDEEFKVGETKIFFKAGVLAKLEDLRD 791

Human   783 EKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSA 847
            |.|::::|..|:..|.:||:.|.::..|::..:..:|.||||:..::.|.|.||:.|:||:||:.
 Worm   792 EILSRIVTMFQSRIRSYLAKAEVRRRYEQQTGLLVVQRNVRAWCTLRTWEWFKLFGKVKPMLKAG 856

Human   848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQL 912
            :.::.|..:..:.:|.:|.:.:.|..|.:||.::..|::|||.|.|.::.|..:|||||||.::|
 Worm   857 KEQEAMGELAVKIQKLEEAVQRGEIARSQLESQVADLVEEKNALFLSLETEKANLADAEERNEKL 921

Human   913 IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 977
            .:.|..||:|:.::|.:.||.:|.|.:|..:|:|.:.|.|:.||.:.||||:|.|.|:||.:.::
 Worm   922 NQLKATLESKLSDITGQLEDMQERNEDLARQKKKTDQELSDTKKHVQDLELSLRKAEQEKQSRDH 986

Human   978 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1042
            .:::|.:|||..||.:|||.||||..:|::::..:|||:||||||.|.|.:.|||||:|:||.::
 Worm   987 NIRSLQDEMANQDEAVAKLNKEKKHQEESNRKLNEDLQSEEDKVNHLEKIRNKLEQQMDELEENI 1051

Human  1043 EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQ 1107
            ::||:.|.|:|:||||:|||||:|||:..:|...|..::..||:||.::....:|:.:..::..:
 Worm  1052 DREKRSRGDIEKAKRKVEGDLKVAQENIDEITKQKHDVETTLKRKEEDLHHTNAKLAENNSIIAK 1116

Human  1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1172
            ||:.||||.||..|||||:||||.||.|:::.||:..|||||::||||:.||||:||:|.|||||
 Worm  1117 LQRLIKELTARNAELEEELEAERNSRQKSDRSRSEAERELEELTERLEQQGGATAAQLEANKKRE 1181

Human  1173 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1237
            ||..|:||:.||.:|.||...::|||:|.||||||.||::.||::|.|.|.|||:::.::::...
 Worm  1182 AEIAKLRREKEEDSLNHETAISSLRKRHGDSVAELTEQLETLQKLKAKSEAEKSKLQRDLEESQH 1246

Human  1238 NMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLV 1302
            ..::..:::.:|||..:.:|.|.||::||.:||.|.:.|..|.:.||..|:.:.:|.|:|.|..:
 Worm  1247 ATDSEVRSRQDLEKALKTIEVQYSELQTKADEQSRQLQDFAALKNRLNNENSDLNRSLEEMDNQL 1311

Human  1303 SQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367
            :.|.|.|.....|::|.:|..:||.:.:.|||...::..|:..:|||..:||.|:||:|.|.:||
 Worm  1312 NSLHRLKSTLQSQLDETRRNYDEESRERQALAATAKNLEHENTILREHLDEEAESKADLTRQISK 1376

Human  1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1432
            .|:|:.||:.:::::.:.:.||:|.|||.|..::|:..:..|.:.||.||.||.:.:|..:::|.
 Worm  1377 LNAEIQQWKARFDSEGLNKLEEIEAAKKALQLKVQELTDTNEGLFAKIASQEKVRFKLMQDLDDA 1441

Human  1433 MIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497
            ..|||:..|..|..:|.:|.|:.|:||||:|.::..:||:|:|:::|.|||:|||.|.|.:|..:
 Worm  1442 QSDVEKAAAQVAFYEKHRRQFESIIAEWKKKTDDLSSELDAAQRDNRQLSTDLFKAKTANDELAE 1506

Human  1498 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKI 1562
            .|::.:||||:|.||:.|||:|:.|||:.:.||:||.:::|.||.|||.||:||||:||.||.|:
 Worm  1507 YLDSTRRENKSLAQEVKDLTDQLGEGGRSVAELQKIVRKLEVEKEELQKALDEAEAALEAEEAKV 1571

Human  1563 LRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1627
            ||.|:|::|::||::::|.||:||.:..:|||.|.:||||:||:||.:.:.:|:|:|||:|.|:|
 Worm  1572 LRAQIEVSQIRSEIEKRIQEKEEEFENTRRNHQRALESMQATLEAETKQKEEALRIKKKLESDIN 1636

Human  1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEEL 1692
            ::||.|:||||..|:|.:..:.....:::.|..:::..|.:::::||....|:|..:||:|.:||
 Worm  1637 DLEIALDHANRAYADAQKTIKKYMETVQELQFQIEEEQRQKDEIREQFLASEKRNAILQSEKDEL 1701

Human  1693 RATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEE 1757
            ....|..||:|:.||.|.::..|:...|:...::|...::|||.::.....|:|:|..|.:||.|
 Worm  1702 AQQAEAAERARRNAEAECIELREQNNDLNAHVSALTGQRRKLEGELLAAHAELEEIANELKNAVE 1766

Human  1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR 1822
            :.:||..|||.:||||::||:.|.|:||::|.||..:|::|.|||:||..|||||||.|.:||||
 Worm  1767 QGQKASADAARLAEELRQEQEHSMHIERIRKGLELQIKEMQIRLDDAENAALKGGKKIIAQLEAR 1831

Human  1823 VRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1887
            :|.:|.|::.||:|:.:..|..||.||:|||:.:|..|::||..||.:||||||.|:|.:|||.|
 Worm  1832 IRAIEQELDGEQRRHQDTEKNWRKAERRVKEVEFQVVEEKKNEERLTELVDKLQCKLKIFKRQVE 1896

Human  1888 EAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSR 1929
            ||||.:..||:|::.:..:.|:|||||||||:.::|:|.|.|
 Worm  1897 EAEEVAASNLNKYKVLTAQFEQAEERADIAENALSKMRNKIR 1938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH1NP_005954.3 Myosin_N 36..73 CDD:280832 13/36 (36%)
Myosin_head 88..770 CDD:278492 407/693 (59%)
MYSc_Myh1_mammals 100..770 CDD:276875 400/681 (59%)
Actin-binding. /evidence=ECO:0000250 659..681 15/21 (71%)
Actin-binding. /evidence=ECO:0000250 761..775 9/13 (69%)
Myosin_tail_1 850..1927 CDD:279860 467/1076 (43%)
RILP-like 965..1098 CDD:304877 61/132 (46%)
MIT_CorA-like <1299..>1411 CDD:294313 38/111 (34%)
DUF342 <1506..1582 CDD:302792 41/75 (55%)
DUF342 <1670..1767 CDD:302792 32/96 (33%)
TMPIT 1744..>1853 CDD:285135 56/108 (52%)
myo-3NP_506065.2 Myosin_N 36..73 CDD:280832 13/36 (36%)
Myosin_head 88..779 CDD:278492 407/693 (59%)
MYSc_class_II 100..779 CDD:276951 400/681 (59%)
Myosin_tail_1 857..1937 CDD:279860 467/1079 (43%)
DUF4795 932..1090 CDD:292662 73/157 (46%)
SPEC 1186..1391 CDD:295325 77/204 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 998 1.000 Domainoid score I8
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1945 1.000 Inparanoid score I16
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - mtm5042
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.870

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