DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and MTA2

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	NP_004730.2	Gene:	MTA2 / 9219	HGNCID:	7411	Length:	668	Species:	Homo sapiens

Alignment Length:	718	Identity:	157/718 - (21%)
Similarity:	239/718 - (33%)	Gaps:	246/718 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDER---ELEESRWSP-GVVADGDLLMFLRAA 66
            |||||||..:|     |::||.      .::.|:|.|   ::|...|.| ..:.|..:..||..|
Human   144 QGEIRVGCKYQ-----AEIPDR------LVEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVA 197

  Fly    67 RSMAAFQGMCD-------GGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVK--CPV-SK 121
            |::..|....|       ..|.....|||||.|..:|:|.|..:|||..||:..||.  .|| .:
Human   198 RAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCR 262

  Fly   122 GIDKKWTEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQ 186
            ...::|:..|...|.:.|.::||:|..|.:|.||.|....:|:|||:||.|        .|..:|
Human   263 DEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTT--------DRYIQQ 319

  Fly   187 SALRRNRVTRANNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDA 251
            ..|:                                ||.|.|:......|..:|
Human   320 KRLK--------------------------------AAEADSKLKQVYIPTYTK----------- 341

  Fly   252 SECDSDSSLTHKRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSS 316
                                      .|.|...|.|:....||.|....::.          .|.
Human   342 --------------------------PNPNQIISVGSKPGMNGAGFQKGLTC----------ESC 370

  Fly   317 SKDQSANAVANGKRPKRGSETPDVSGGASVDSPKTPTKAVAESSANKRKGGKQDTPNKKKRTEQE 381
            ...|||...|.|                   .|....:..|......:|.|...||.:.:...:.
Human   371 HTTQSAQWYAWG-------------------PPNMQCRLCASCWIYWKKYGGLKTPTQLEGATRG 416

  Fly   382 SNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQ-------------Q 433
            :.||  |....:                 |||::     :|.:..||:|.:             |
Human   417 TTEP--HSRGHL-----------------SRPEA-----QSLSPYTTSANRAKLLAKNRQTFLLQ 457

  Fly   434 STKDSKETVSCKEEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADT--- 495
            :||.::  ::.:..|:::.....|:.....|.|.|:            ..|.:|:.|.:|.|
Human   458 TTKLTR--LARRMCRDLLQPRRAARRPYAPINANAI------------KAECSIRLPKAAKTPLK 508

  Fly   496 --SLVDGPNPNALPSPVA-APITMKVP--TIATVEALNASVDR-------KEAIEKME------S 542
              .||..|....:...|| ||:..|.|  |...:.....|.:|       |.|.|.|.      |
Human   509 IHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGVPFS 573

  Fly   543 CDSDPEMLKKLAT-IKQEVSPQQQQHMQQQSQQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMED 606
            .:..|     ||: |:....|..:           :|:|.|...|.|.....::.....::.:..
Human   574 ANGRP-----LASGIRSSSQPAAK-----------RQKLNPADAPNPVVFVATKDTRALRKALTH 622

  Fly   607 SMDATCNQNSNEPQDLKVK---IEIKNEDALKHSAGGLPPSGPCAPPSALHPLSGAPVESGQEPL 668
            .......:..|.|  ||||   |.::             |..|...||  ||      .|..||:
Human   623 LEMRRAARRPNLP--LKVKPTLIAVR-------------PPVPLPAPS--HP------ASTNEPI 664

  Fly   669 HLQ 671
            .|:
Human   665 VLE 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	18/62 (29%)
		SANT	125..172	CDD:197842	18/46 (39%)
		SANT_MTA3_like	126..171	CDD:212559	17/44 (39%)
		Sec_Non_Glob	344..>440	CDD:275213	19/108 (18%)
MTA2	NP_004730.2	BAH_MTA	3..168	CDD:240060	12/34 (35%)
		ELM2	147..198	CDD:307553	17/61 (28%)
		SANT_MTA3_like	267..312	CDD:212559	17/44 (39%)
		ZnF_GATA	363..414	CDD:214648	12/79 (15%)
		Atrophin-1	<405..664	CDD:331285	67/335 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..437		7/51 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..599		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..668		10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D802091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920