DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and rereb

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	XP_005166160.1	Gene:	rereb / 799473	ZFINID:	ZDB-GENE-070212-3	Length:	1216	Species:	Danio rerio

Alignment Length:	2142	Identity:	459/2142 - (21%)
Similarity:	609/2142 - (28%)	Gaps:	1112/2142 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARS 68
            ||||||||||.||     ||||:..|..:...:..|:..:|.   |:|| |.|.||||:||||||
Zfish    13 STQGEIRVGPSHQ-----AKLPELQPPPAHGTESVTENEDLV---WAPG-VNDCDLLMYLRAARS 68

  Fly    69 MAAFQGMCDGG-LEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDET 132
            ||||.|||||| .|||||||||||||:|||:.||:|.||..||||.|||.||.|.|:|.|:|||.
Zfish    69 MAAFAGMCDGGSTEDGCLAASRDDTTLNALNTLHESQYDAAKALQCLVKKPVPKLIEKSWSEDEV 133

  Fly   133 KKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRA 197
            |:|||||||:|||||:|.|||||.|.|.||:.|||.|||||.|...||||::|:..:.|...||
Zfish   134 KRFIKGLRQYGKNFFKIRKDLLPSKKTGELITFYYYWKKTPEAVAARPHRQQRRQPVSRKVKTR- 197

  Fly   198 NNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDASECDSDSSLTH 262
                                 .|||||.|.|.|:|.        |.||.:|||....||:..  .
Zfish   198 ---------------------NATAAANATSRTSSM--------ELSSASEDDLDSEDSEQG--G 231

  Fly   263 KRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSSSKDQSANAVAN 327
            ||......:.|.:|..::            .|..|....||..|        ..||.:....|
Zfish   232 KRQACSHCLSTNSKDWHH------------GGRDNVLLCSSCHT--------HFSKHRRLPPV-- 274

  Fly   328 GKRPKRGSETPDVSGGASVDSPK--TPTKAVAESSANKRKGGKQDTPNKKKRTEQESNEPSAHEE 390
               ||            ..|.|.  .|.|...|.|.:..|..:...|..........|.|:...|
Zfish   275 ---PK------------PADPPYLFKPVKEEEEESRHGMKTRRSRVPPHMSSLRSGRNRPTGSPE 324

  Fly   391 NAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQQSTKDSKETVSCKEEREMVTNDL 455
            ..:..    |...|......||        .|:||.||.|   |:.|.|..|:.|..::|
Zfish   325 RGLSP----PSEDVRPNGQSSR--------ASSTTMTTRA---SSSDMKNGVAGKTNKKM----- 369

  Fly   456 EAKAEEKAIKA-----EALAEDSKDSAIKNMDEETNIQAPSSADTSLVDGPNPNALPSPVAAPIT 515
              |.|...:|.     |:.|.|:.:...|||....|.:.|.|              ||
Zfish   370 --KVEASVVKGVKRQRESAAPDADEPERKNMKRPKNQEGPDS--------------PS------- 411

  Fly   516 MKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQSQQQMQQQL 580
                                      .|:.:.|
Zfish   412 --------------------------ECEGEGE-------------------------------- 418

  Fly   581 APVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHSAGGLPPSG 645
                        .|:|....::...|:.|...:..|:.| .|...::....|:          ..
Zfish   419 ------------SSDSRSANEDGSSDTKDIDQDNRSSSP-SLASPLQANESDS----------DS 460

  Fly   646 PCAPPSALHPLSGAPVESGQEPLHLQHMPHGQVTTQPPPGYLIDGQLKYGPSGQGVPPQPPQLHS 710
            |..||::                                          ||..|..|.||
Zfish   461 PAPPPAS------------------------------------------GPITQAQPQQP----- 478

  Fly   711 DAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQDLKYPPPPPLDALKYSQEMQAAAAAAAAAGKYDM 775
             ||...:..|..:|.:||...|                      .:|......||......|
Zfish   479 -AAASTTHTPSESPPSPQPTLP----------------------TFSSAPSPGAATTTVTSK--- 517

  Fly   776 KYMMEQQGKYNVELSAAHQPPSKPGYQDSLKIPDIKPGFGHLPHNVGSPLDAAHKYGPPPTS-QE 839
                                  .|..:.:|.:|.            .||..:..|....||| ..
Zfish   518 ----------------------APSAETTLDVPS------------PSPFRSGPKAPEAPTSYSN 548

  Fly   840 SQQQQPQPPAHQVPPGATPPPGIAMPKP-HYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYGPPQ 903
            |..||.|.|..          |.::|.| ||||:
Zfish   549 SSSQQVQCPGQ----------GQSLPVPAHYQHN------------------------------- 572

  Fly   904 DLKYPMPPVSQAGPADVKPYGGENLIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPPSMPP 968
                                                          .||....|:..:||.....
Zfish   573 ----------------------------------------------SGQLQNPSSGANQPQGFTS 591

  Fly   969 QPQQFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTSAGPP 1033
            :|...|...|.|.:|:.|                                 ||..:|.||:..||
Zfish   592 RPLHLQRESPFPPLPATA---------------------------------TSQIKPPPTTPIPP 623

  Fly  1034 SLQHGLHPGHQHSQLSVASSIPPSSIGIPPTLSTMAPS--HMHPHLHPHAHLQGLHRPHDLPPSM 1096
            |          |.|              ||.||...|.  .:||:|.|             ||::
Zfish   624 S----------HKQ--------------PPHLSAPPPHFLQIHPNLPP-------------PPAL 651

  Fly  1097 HPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPPRSMHDPQSSR 1161
            .|.|.:|      .||                                .|:.|||.....||::.
Zfish   652 KPLASLP------SQH--------------------------------LPSSQPPPLHVIPQNNP 678

  Fly  1162 EPPTSQPSTTMAGSSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPMAIHPHLAHLPPGH 1226
            .||:....|            ..|...:| :|..|.:|.|..||                |||..
Zfish   679 APPSVLTQT------------QSQQVKSH-SSAAPQVAASSHPP----------------LPPNR 714

  Fly  1227 PAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPHSHASSAPLT 1291
            |:                                      |||
Zfish   715 PS--------------------------------------PES---------------------- 719

  Fly  1292 AHSVASMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSSAAAAAAAAAH 1356
                    :.|..|.||.:
Zfish   720 --------TASYPLYTSPI---------------------------------------------- 730

  Fly  1357 RAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQSPHMTPPPVSN 1421
                               |||    :|.||:|  |:|:..|.:    |:::::       ||..
Zfish   731 -------------------PVP----AHQPSTS--SSASTPVGQ----AIIKEE-------PVDE 759

  Fly  1422 ASLMASPLSKMYAPQPGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPGGGIPQIGVHPGQ 1486
            .....||                 |||...|..:|.|:
Zfish   760 EEECDSP-----------------PPPRRSPSPAPTVV--------------------------- 780

  Fly  1487 SPYPHPLLHPSVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGPPP 1551

Zfish   781 ----------------------------------------------------------------- 780

  Fly  1552 QQMRQDEQNAAAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGMPPNKPPTPKTPQGPGGGMPP 1616

Zfish   781 ----------------------------------------------------------------- 780

  Fly  1617 GMGGPGTPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGM 1681

Zfish   781 ----------------------------------------------------------------- 780

  Fly  1682 GGGHHPTEPLPIDIEPDPEPEIPSPTHNIPRGPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCT 1746
                                :|||                    |.||||.|::|::|| ||||:
Zfish   781 --------------------DIPS--------------------HASQSARFIKHLNRG-YNSCS 804

  Fly  1747 RTDLIFKPVADSKLARKRE---ERDRKLA------------EKERER-RQQQQQQQQQQQQQQAA 1795
            ||||.|.|:..||||:|||   ||.|:.|            |:|||| |::::::::::...:|:
Zfish   805 RTDLYFTPLTSSKLAKKREEAAERSRREAELSARQGRERERERERERERERERERERERDSDKAS 869

  Fly  1796 AAQQAAQQAKMKAEL----------------------KPPY--ADTPALRQLSEYARPHVAFSPV 1836
            .|..::...::...|                      .|||  .||||||.||||||||| .||.
Zfish   870 RASSSSHDGRISEHLLAAHVQPGRPSFEPPPPTTVAAVPPYLGPDTPALRTLSEYARPHV-MSPT 933

  Fly  1837 EQMVPYHHPMGP-----------MY------RERELEEIKNAQAAAASQSRLDPHW--------- 1875
            .:..|:..|:||           :|      |||||.|::..:.    :.|:.|.:
Zfish   934 NRNHPFFMPLGPGEHLLAYHMPGLYAADPALRERELRELREREI----RERMKPGFEVKPPELEN 994

  Fly  1876 --------MEYYRR----------------GIHPSQFPLYA---NPAISQMER---ERLGIPPPH 1910
                    ||::.|                ..||:.....|   .|.||..||   |||......
Zfish   995 PLHPSANPMEHFARHGALPLAHVAGPHHFAQFHPAMERNVAAPPRPEISYAERLTAERLHAERMA 1059

  Fly  1911 HVGL-DPGE--HMIRLTREYHAHSHTHLHLPLHPQ--------PQPPEAGFQLPPNVGQYPRP-- 1962
            .|.. ||..  .|:.:|..:|.|||.|.||.||.|        |.|........|.:.::|.|
Zfish  1060 SVAAGDPVARLQMLNVTPHHHQHSHIHSHLHLHQQDPLNQGQGPHPLVDPLAAGPPLARFPYPPG 1124

  Fly  1963 ---NMLIPREPHSDVLLR------------------MSYADQLQYLQA--AEFQRQSLHDQY 2001
               |.|:...||...:||                  ||.|.|||.:||  ||.||.:|..|:
Zfish  1125 AITNPLLSELPHEHEMLRHPLFGAPFPRELPGPLAPMSAAHQLQAMQAQSAELQRLALEQQW 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	27/58 (47%)
		SANT	125..172	CDD:197842	33/46 (72%)
		SANT_MTA3_like	126..171	CDD:212559	31/44 (70%)
		Sec_Non_Glob	344..>440	CDD:275213	23/97 (24%)
rereb	XP_005166160.1	ELM2	18..68	CDD:279754	27/58 (47%)
		SANT	126..173	CDD:197842	33/46 (72%)
		SANT_MTA3_like	127..172	CDD:212559	31/44 (70%)
		ZnF_GATA	235..>270	CDD:238123	9/54 (17%)
		Atrophin-1	294..1215	CDD:281189	302/1783 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581447
Domainoid	1	1.000	125	1.000	Domainoid score	I5416
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2451
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm25891
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.980