DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and Rere

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	XP_006539199.1	Gene:	Rere / 68703	MGIID:	2683486	Length:	1569	Species:	Mus musculus

Alignment Length:	2182	Identity:	514/2182 - (23%)
Similarity:	658/2182 - (30%)	Gaps:	1107/2182 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARS 68
            ||||||||||.||     |||||..|..|...|..|...||.   |.|| |:|.||||:||||||
Mouse   281 STQGEIRVGPSHQ-----AKLPDLQPFPSPDGDTVTQHEELV---WMPG-VSDCDLLMYLRAARS 336

  Fly    69 MAAFQGMCDGG-LEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDET 132
            ||||.|||||| .||||:||||||||:|||:.||:|.||.|||||.|||.||.|.|:|.|||||.
Mouse   337 MAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESSYDAGKALQRLVKKPVPKLIEKCWTEDEV 401

  Fly   133 KKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRA 197
            |:|:|||||:|||||||.|:|||.|:|.||:.|||.|||||.|.::|.|||.|:.|:.|...||.
Mouse   402 KRFVKGLRQYGKNFFRIRKELLPSKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRT 466

  Fly   198 NNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDASECDSDSSLTH 262
            .::..|||.:                           .|:....:.||.:|||....||:..|.
Mouse   467 ASTPVNTPSR---------------------------PPSSEFLDLSSASEDDFDSEDSEQELK- 503

  Fly   263 KRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSSSKDQSANAVAN 327
                                             |.|......:|          |||..     :
Mouse   504 ---------------------------------GYACRHCFTTT----------SKDWH-----H 520

  Fly   328 GKRP------------KRGSETPDVSGGASVDSPKTPTKAVAESSANKRKGGKQDTPNKKKRTEQ 380
            |.|.            |:..|.|.:.  ..||.|....|.|.|..     .|.....:.:.|..:
Mouse   521 GGRENILLCTDCRIHFKKYGELPPIE--KPVDPPPFMFKPVKEED-----DGLSGKHSMRTRRSR 578

  Fly   381 ESNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQQSTKDSK-ETVSC 444
            .|.:.|.....    ::|:|.||      |.|...:.:|..|:..::.:|...|:.||| |||
Mouse   579 GSGQMSTLRSG----RKKQPTSP------DGRASPINEDIRSSGRNSPSAASTSSNDSKAETV-- 631

  Fly   445 KEEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADTSLVDGPNPNALPSP 509
                         |...|.:|.||
Mouse   632 -------------KKSAKKVKEEA----------------------------------------- 642

  Fly   510 VAAPITMKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQSQQ 574
             |:|:.                ..|...||:.|...|.:.:....|..||:|.
Mouse   643 -ASPLK----------------STKRQREKVASDTEDTDRITSKKTKTQEISR------------ 678

  Fly   575 QMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHSAG 639
                       |..||....||        .||.... ::.|::|:|:
Mouse   679 -----------PNSPSEGEGES--------SDSRSVN-DEGSSDPKDI----------------- 706

  Fly   640 GLPPSGPCAPPSALHPLSGAPVESGQEPLHLQHMPHGQVTTQPPPGYLIDGQLKYGPSGQGVPPQ 704

Mouse   707 ----------------------------------------------------------------- 706

  Fly   705 PPQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQDLKYPPPPPLDALKYSQEMQAAAAAAAA 769
                                                                .|:.::.:
Mouse   707 ----------------------------------------------------DQDNRSTS----- 714

  Fly   770 AGKYDMKYMMEQQGKYNVELSAAHQPPSKPGYQDSLKIPDIKPGFGHLPHNVGSPLDAAHKYGPP 834
                                      ||.|..||:....|
Mouse   715 --------------------------PSIPSPQDNESDSD------------------------- 728

  Fly   835 PTSQESQQQQPQPPAHQVPPGATPPPGIAMPKPHYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKY 899
             :|.:.|..|.||||.|.|.||...|             .|.|.|.|..||
Mouse   729 -SSAQQQMLQAQPPALQAPSGAASAP-------------STAPPGTPQLPT-------------- 765

  Fly   900 GPPQDLKYPMPPVSQAGPADVKPYGGENLIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPP 964
                                              .||.|      ||.:.|   .|||.:.||||
Mouse   766 ----------------------------------QGPTP------SATAVP---PQGSPATSQPP 787

  Fly   965 SMPPQPQQFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTS 1029
            :   |.|...:|....|:..      .|.:||..|             |.|.||
Mouse   788 N---QTQSTVAPAAHTHIQQ------APTLHPPRL-------------PSPHPP----------- 819

  Fly  1030 AGPPSLQHGLHPGHQHSQLSVASSIPPSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDL-- 1092
                     |.|          .:.|||.            |...||..|..|.||...||.|
Mouse   820 ---------LQP----------MTAPPSQ------------SSAQPHPQPSLHSQGPPGPHSLQT 853

  Fly  1093 -PPSMHPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPPRSMHD 1156
             |...||..|.|..|           ||..||.|          ||.|    ||||     :.|
Mouse   854 GPLLQHPGPPQPFGL-----------PSQPSQGQ----------GPLG----PSPA-----AAH- 887

  Fly  1157 PQSSREPPTSQPSTTMAGSSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPMAIHPHLAH 1221
            |.|:.:.|.||.:.           .|||.|   |..|||      |.|..:        ||:..
Mouse   888 PHSTIQLPASQSAL-----------QPQQPP---REQPLP------PAPLAM--------PHIKP 924

  Fly  1222 LP----PGHPAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPH 1282
            .|    |..||..|..||.|                   |:||.     |.|..:...||.
Mouse   925 PPTTPIPQLPAPQAHKHPPH-------------------LSGPS-----PFSLNANLPPPP---- 961

  Fly  1283 SHASSAPLTAHSVASMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSSA 1347

Mouse   962 ----------------------------------------------------------------- 961

  Fly  1348 AAAAAAAAHRAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQSP 1412
                      |..|.||:|                :|||                         |
Mouse   962 ----------ALKPLSSLS----------------THHP-------------------------P 975

  Fly  1413 HMTPPPVSNASLMASPLSKMYAPQPGQRGLGTSPPPHLRPGAS--PPVIRHPQMPLPLPLIAPGG 1475
            ...|||     |...|.|:.....|.|       ||.|....|  ||...||..
Mouse   976 SAHPPP-----LQLMPQSQPLPSSPAQ-------PPGLTQSQSLPPPAASHPTT----------- 1017

  Fly  1476 GIPQIGVHPGQSPYPHPLLHPSVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVMA 1540
            |:.|:   |.|||:|             .|||                     .||
Mouse  1018 GLHQV---PSQSPFP-------------QHPF---------------------VPG--------- 1036

  Fly  1541 AHHAGLQGPPPQQMRQDEQNAAAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGMPPNKPPTPK 1605
                   ||||.                                           .||:.|||..
Mouse  1037 -------GPPPI-------------------------------------------TPPSCPPTST 1051

  Fly  1606 TPQGPGGGMPPGMGGPGTPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDALR 1670
            .|.||.....|......:..|..|||
Mouse  1052 PPAGPSSSSQPPCSAAVSSGGSVPGA--------------------------------------- 1077

  Fly  1671 AHAHSANSAGMGGGHHPTEPLP-IDIEPD-----PEPEIPSPTHNIPRGPSPEAKPDDTECHRSQ 1729
                            |:.||| :.|:.:     .|||.|.|.   ||.||||....||..|.||
Mouse  1078 ----------------PSCPLPAVQIKEEALDEAEEPESPPPP---PRSPSPEPTVVDTPSHASQ 1123

  Fly  1730 SAIFVRHIDRGDYNSCTRTDLIFKPVADSKLARKREERDRKL---------AEKERERRQQQQQQ 1785
            ||.|.:|:||| ||||.||||.|.|:|.||||:||||...|.         .|:|||:.::::::
Mouse  1124 SARFYKHLDRG-YNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERE 1187

  Fly  1786 QQQQQQQQAAAAQQAAQQAKMKAELK------------------------PPY--ADTPALRQLS 1824
            ::::::::|..|.|.|..:..:..|.                        |||  .||||||.||
Mouse  1188 REREREREAERAAQKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLS 1252

  Fly  1825 EYARPHV------------AFSPVEQMVPYHHP----MGPMYRERELEEIKNAQAAAASQS---- 1869
            |||||||            ..:|.:.::.||.|    :.|..|||||.|.:..:.....:.
Mouse  1253 EYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRER 1317

  Fly  1870 ----------RLDP-----HWMEYYRR----------GIHPSQFPLYANPAISQMERERLGIPPP 1909
                      .|||     :.||::.|          |.||  |..: :|.::.:|||||.:..|
Mouse  1318 MKPGFEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHP--FASF-HPGLNPLERERLALAGP 1379

  Fly  1910 HHVGLDP--------------GEHMIRLTRE---------------YHAHSHTHLHL-------- 1937
            .   |.|              .|.|..||.:               .|:|.|:||||
Mouse  1380 Q---LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQ 1441

  Fly  1938 ----PLHPQPQPPEAGFQLPPNVGQYP-----RPNMLIPREPHSDVLLR---------------- 1977
                |:||...|..||    |::.::|     .||.|:.:.||...:||
Mouse  1442 GSAGPVHPLVDPLTAG----PHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFAEPVLRLAGTPY 1502

  Fly  1978 -----------MSYADQLQ--YLQAAEFQRQSLHDQY 2001
                       ||.|.|||  :.|:||.||.::..|:
Mouse  1503 PRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQW 1539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	31/58 (53%)
		SANT	125..172	CDD:197842	33/46 (72%)
		SANT_MTA3_like	126..171	CDD:212559	31/44 (70%)
		Sec_Non_Glob	344..>440	CDD:275213	23/96 (24%)
Rere	XP_006539199.1	BAH_MTA	102..307	CDD:240060	19/30 (63%)
		ELM2	286..336	CDD:366648	31/58 (53%)
		SANT_MTA3_like	395..440	CDD:212559	31/44 (70%)
		ZnF_GATA	503..552	CDD:214648	13/99 (13%)
		Atrophin-1	568..1568	CDD:367360	358/1803 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837713
Domainoid	1	1.000	185	1.000	Domainoid score	I3374
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3476
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S7094
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm43372
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5144
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.960