DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and rerea

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	XP_005162258.1	Gene:	rerea / 569081	ZFINID:	ZDB-GENE-060718-1	Length:	1531	Species:	Danio rerio

Alignment Length:	2188	Identity:	490/2188 - (22%)
Similarity:	652/2188 - (29%)	Gaps:	1114/2188 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARS 68
            ||||||||||.||     ||||:..|   ||........|.||..|.|| |.|.||||:||||||
Zfish   238 STQGEIRVGPSHQ-----AKLPELQP---FPSPGGQTVTENEELVWMPG-VNDCDLLMYLRAARS 293

  Fly    69 MAAFQGMCDGG-LEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDET 132
            ||||.|||||| .|||||||||||||:|||:.||:|.||.|||||.|||.||.|.|:|.|:|||.
Zfish   294 MAAFAGMCDGGSTEDGCLAASRDDTTLNALNTLHESSYDAGKALQRLVKKPVPKLIEKCWSEDEV 358

  Fly   133 KKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRA 197
            |:|||||||:|||||||.|:|||:|:|.||:.|||.|||||.|.:.|.|||.|:..:.|...||.
Zfish   359 KRFIKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASCRAHRRHRRQPVFRRIKTRT 423

  Fly   198 NNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDASECDSDSSL-- 260
            .::..|||.:                           .|:....:.||.:|||....||:..|
Zfish   424 ASTPVNTPSR---------------------------PPSSEFLDLSSASEDDFDSEDSEQELKG 461

  Fly   261 --------THKRD--------------------------------ESPSRMRTRNKQQNNNSSTS 285
                    |..:|                                :.|..|....|::::..|..
Zfish   462 YACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGK 526

  Fly   286 SGNNTAGNGGGNATSISSGSTGGGAAGGNSSSKDQSANAVANGKRPKRGSETPDVSGGASVDSPK 350
            ....|..|.|..:|..|.......:..|.:|..::...:        .|..:|..:..:|.||
Zfish   527 HSMRTRRNRGSMSTLRSGRKKQTASPDGRASPTNEDLRS--------SGRTSPSAASTSSTDS-- 581

  Fly   351 TPTKAVAESSANKRKGGKQDTPNKKKRTEQESNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDS 415
                          |......|:||.:.|..|...||        ||:|
Zfish   582 --------------KTDSMKKPSKKTKEEAPSPMKSA--------KRQR---------------- 608

  Fly   416 VLDDGESNTTDTTTAEQQSTKDSKETVSCKEEREMVTNDLEAKAEEKAIKAEALA-EDSKDSAIK 479
                 |...:||..:|:.|.|.||     .:|..:..:..|.:.|.:...::..: .|...|..|
Zfish   609 -----EKGASDTEESERASAKKSK-----TQEISVPNSPSECEGEGEGESSDGRSVNDEGSSDPK 663

  Fly   480 NMDEETNIQAPSSADTSLVDGPNPNALPSPVAAPITMKVPTIATVEALNASVDRKEAIEKMESCD 544
            ::|::....:||              :|||                             :....|
Zfish   664 DIDQDNRSSSPS--------------IPSP-----------------------------RDNESD 685

  Fly   545 SDPEMLKKLATIKQEVSPQQQQHMQQQSQQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMD 609
            ||              |..|||.:|.|               .||
Zfish   686 SD--------------SSAQQQILQGQ---------------HPP-------------------- 701

  Fly   610 ATCNQNSNEPQDLKVKIEIKNEDALKHSAGGLPPSGPCAPPSALHPLSGAPVESGQEPLHLQHMP 674
                                   .::...|.|||:.|.|..::..|.||||
Zfish   702 -----------------------VIQCQTGTLPPAPPPAAAASTTPTSGAP-------------- 729

  Fly   675 HGQVTTQPPPGYLIDGQLKYGPSGQGVPP--QPPQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMK 737
              .:::||.|               .:||  .|||
Zfish   730 --SLSSQPSP---------------SIPPTSMPPQ------------------------------ 747

  Fly   738 FAPQDLKYPPPPPLDALKYSQEMQAAAAAAAAAGKYDMKYMMEQQGKYNVELSAAHQPPSKPGYQ 802
                  :.||..||..::                                  |...:.||
Zfish   748 ------QIPPAGPLSLIQ----------------------------------SGVQRLPS----- 767

  Fly   803 DSLKIPDIKPGFGHLPHNVGSPLDAAHKYGPPPTSQESQQQQPQPPAHQVPPGATPPPGIAMPKP 867
                           ||   |||....:  |||.||...|.. |||.|    |..||.|
Zfish   768 ---------------PH---SPLQGMPQ--PPPPSQTCPQAL-QPPLH----GPMPPMG------ 801

  Fly   868 HYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYGPPQDLKYPMPPVSQAGPADVKPYGGENLIKSS 932
               |.:|..|...| .|..|             |.|  .:||.. ||..|:   |..|:....|.
Zfish   802 ---HPLQAGPSHMP-HPHAL-------------PTQ--PFPMAQ-SQVPPS---PLSGQAQAASL 843

  Fly   933 PYGPPPESPIDASARSTPGQDSQGSNSNSQPPSMPPQPQQFQSPHPSPHMPSPAGGGLPPGMHPQ 997
            .....|.:|        |.|....|.|.||||...|.|   .:|.|.||:
Zfish   844 SQQQRPHTP--------PSQSQSSSQSGSQPPREQPLP---PAPLPMPHI--------------- 882

  Fly   998 NLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTSAGPPSLQHGLHPGHQHSQLSVASSIPPSSIGIP 1062
                              .||||:   |.|..   |:.|...||.|           ||    .|
Zfish   883 ------------------KPPPTT---PIPQM---PNAQSHKHPSH-----------PP----FP 908

  Fly  1063 PTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPPSMHPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQ 1127
            ...|.:.|.   |.|.|.:.|...|     |||.||                  ||.....|.||
Zfish   909 QMPSNLPPP---PALKPLSSLSNHH-----PPSAHP------------------PPLQLMSQSQQ 947

  Fly  1128 QQQQQQPGGPAGTVRTPSPAQQPPRSMHDPQSSREPPTSQPSTTMAGSSGPGGPPPQQSPHAHRT 1192
            .|                                                   |||.|.|...::
Zfish   948 LQ---------------------------------------------------PPPVQPPVLTQS 961

  Fly  1193 SPLPGLAGSGPPPPGLIGHPMAIHPHLAHLPPGHPAHAALAHPGHHLLSHSIAGLGPGGGPIALL 1257
            ..||......|||                .||
Zfish   962 QTLPATGSQAPPP----------------APP--------------------------------- 977

  Fly  1258 AGPGGLGGIPESALSRRTPPSHLPHSHASSAPLTAHSVASMTSTSMSLTTSTVPSSAFSRASPSV 1322
                    :|.|        |...||..|..|...||.  |..:|..|:.||||:|.
Zfish   978 --------LPSS--------SSASHSAPSQPPFPPHSF--MPGSSPVLSPSTVPTSV-------- 1016

  Fly  1323 QISSSGGGPSGPGSVGPGGMPNSSAAAAAAAAAHRAASPASSVSSLSRQSPLHPVPQSPLSHHPS 1387
                                                   :||:::|.:
Zfish  1017 ---------------------------------------SSSMTTLQQ----------------- 1025

  Fly  1388 SSALSAAAAAVAERDRHALMRQQSPHMTPPPVSNASLMASPLSKMYAPQPGQRGLGTSPPPHLRP 1452
                                                                      |||.:
Zfish  1026 ----------------------------------------------------------PPPSI-- 1030

  Fly  1453 GASPPVIRHPQMPLPLPLIAPGGGIPQIGVHPGQSPYPHPLLHPSVFYSPHHHPFNSPYGYAPYG 1517
                      .||||..:.||..|
Zfish  1031 ----------SMPLPASVSAPCPG----------------------------------------- 1044

  Fly  1518 PGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGPPPQQMRQDEQNAAAAAAQAAAEKQHQAAAAAAA 1582
                             |:.|           ||.|:::
Zfish  1045 -----------------PSTV-----------PPVQIKE-------------------------- 1055

  Fly  1583 QQHKAPQQQQPGGMPPNKPPTPKTPQGPGGGMPPGMGGPGTPTGLPPGAYPGSHMPGYPQGPPHG 1647

Zfish  1056 ----------------------------------------------------------------- 1055

  Fly  1648 SPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGMGGGHHPTEPLPIDIEPDPEPEIPSPTHNIPR 1712
                                                     |||    :...|||.|.|..   |
Zfish  1056 -----------------------------------------EPL----DETEEPESPPPPQ---R 1072

  Fly  1713 GPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCTRTDLIFKPVADSKLARKREE----------- 1766
            .|||.....:|..|.||||.|.:|:||| ||:|.|||..|.|:|.||||:||||
Zfish  1073 SPSPPPTIVNTPSHASQSARFYKHLDRG-YNTCARTDFYFTPLASSKLAKKREEALEKAKREAEQ 1136

  Fly  1767 RDRKLAEKERER-RQQQQQQQQQQQQQQAAAAQQAAQQAKM-------KAELK------------ 1811
            :.|:..|||||| ::::::::::::.::||.|..::.:::|       .|.::
Zfish  1137 KAREEKEKEREREKEREREREREKEAERAAKASSSSHESRMGEPPMAGSAHMRTSFDPPPTTIAT 1201

  Fly  1812 -PPY--ADTPALRQLSEYARPH------------VAFSPVEQMVPYHHP----MGPMYRERELEE 1857
             |||  .||||||.||||||||            |:.:|.:.::.||.|    ..|..|||||.|
Zfish  1202 VPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVSLNPTDPLLAYHLPGLYNADPSMRERELRE 1266

  Fly  1858 ----IKNAQAAAASQSRLDPHW----------------MEYYRR----------GIHPSQFPLYA 1892
                .:..:.......|:.|.:                ||::.|          |.||  |..:
Zfish  1267 REIREREIRERELRMERMKPGFEVKPPELDSLHPSANPMEHFARHGPIGLPPMAGPHP--FASF- 1328

  Fly  1893 NPAISQMERERLGIPPPH---------------HVGLDPGEHMIRL-----TREYHAHSHTHLHL 1937
            :|.::.:|||||.:..|.               ||.....:.|.||     |..:|.|||.|.||
Zfish  1329 HPGLNPLERERLALAGPQLRPEMTYPERLAERLHVERLANDPMARLQMFNVTPHHHQHSHIHSHL 1393

  Fly  1938 PLHPQPQPPEAGFQ---LPPNVGQYPR--------------------PNMLIPREPHSDVLLR-- 1977
            .||.|....:.|.:   .||..|.:|.                    ||.|:.:.||...:||
Zfish  1394 HLHQQDPLHQGGGECLVCPPGSGAHPLVDPLAGGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHP 1458

  Fly  1978 -----------------MSYADQLQ--YLQAAEFQRQSLHDQY 2001
                             ||.|.|||  :.|:||.||.::..|:
Zfish  1459 VFGTPYPRDLPAGLPPPMSAAHQLQAMHAQSAELQRLAMEQQW 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	30/58 (52%)
		SANT	125..172	CDD:197842	33/46 (72%)
		SANT_MTA3_like	126..171	CDD:212559	31/44 (70%)
		Sec_Non_Glob	344..>440	CDD:275213	21/95 (22%)
rerea	XP_005162258.1	BAH_MTA	101..264	CDD:240060	19/33 (58%)
		ELM2	243..293	CDD:307553	30/58 (52%)
		SANT_MTA3_like	352..397	CDD:212559	31/44 (70%)
		ZnF_GATA	460..509	CDD:214648	2/48 (4%)
		Atrophin-1	525..1530	CDD:331285	347/1865 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581449
Domainoid	1	1.000	125	1.000	Domainoid score	I5416
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2451
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm25891
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5144
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.010