DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and RERE

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	NP_001036146.1	Gene:	RERE / 473	HGNCID:	9965	Length:	1566	Species:	Homo sapiens

Alignment Length:	2175	Identity:	514/2175 - (23%)
Similarity:	667/2175 - (30%)	Gaps:	1096/2175 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARS 68
            ||||||||||.||     |||||..|..|...|..|...||.   |.|| |.|.||||:||||||
Human   281 STQGEIRVGPSHQ-----AKLPDLQPFPSPDGDTVTQHEELV---WMPG-VNDCDLLMYLRAARS 336

  Fly    69 MAAFQGMCDGG-LEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDET 132
            ||||.|||||| .||||:||||||||:|||:.||:||||.|||||.|||.||.|.|:|.|||||.
Human   337 MAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEV 401

  Fly   133 KKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRA 197
            |:|:|||||:|||||||.|:|||:|:|.||:.|||.|||||.|.::|.|||.|:.|:.|...||.
Human   402 KRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRT 466

  Fly   198 NNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDASECDSDSSLTH 262
            .::..|||.:                           .|:....:.||.:|||....||:..|.
Human   467 ASTPVNTPSR---------------------------PPSSEFLDLSSASEDDFDSEDSEQELK- 503

  Fly   263 KRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSSSKDQSANAVAN 327
                                             |.|......:|          |||..     :
Human   504 ---------------------------------GYACRHCFTTT----------SKDWH-----H 520

  Fly   328 GKRP------------KRGSETPDVSGGASVDSPKTPTKAVAESSANKRKGGKQDTPNKKKRTEQ 380
            |.|.            |:..|.|.:.  ..||.|....|.|.|.  :....||.....::.|...
Human   521 GGRENILLCTDCRIHFKKYGELPPIE--KPVDPPPFMFKPVKEE--DDGLSGKHSMRTRRSRGSM 581

  Fly   381 ESNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQQSTKDSK-ETV-- 442
            .:....         ::|:|.||      |.|...:.:|..|:..::.:|...|:.||| |||
Human   582 STLRSG---------RKKQPASP------DGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKK 631

  Fly   443 SCKEEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADTSLVDGPNPNALP 507
            |.|:.:|..::.|::...::    |.:|.|::::
Human   632 SAKKVKEEASSPLKSNKRQR----EKVASDTEEA------------------------------- 661

  Fly   508 SPVAAPITMKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQS 572
                                    ||..:              ||..|  ||:|.
Human   662 ------------------------DRTSS--------------KKTKT--QEISR---------- 676

  Fly   573 QQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHS 637
                         |..||....||        .||.... ::.|::|:|:
Human   677 -------------PNSPSEGEGES--------SDSRSVN-DEGSSDPKDI--------------- 704

  Fly   638 AGGLPPSGPCAPPSALHPLSGAPVESGQEPLHLQHMPHGQVTTQPPPGYLIDGQLKYGPSGQGVP 702

Human   705 ----------------------------------------------------------------- 704

  Fly   703 PQPPQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQDLKYPPPPPLDALKYSQEMQAAAAAA 767
                                                                  .|:.::.:
Human   705 ------------------------------------------------------DQDNRSTS--- 712

  Fly   768 AAAGKYDMKYMMEQQGKYNVELSAAHQPPSKPGYQDSLKIPDIKPGFGHLPHNVGSPLDAAHKYG 832
                                        ||.|..||:....|
Human   713 ----------------------------PSIPSPQDNESDSD----------------------- 726

  Fly   833 PPPTSQESQQQQPQPPAHQVPPGATPPPGIAMPKPHYQHDVQTPPLGRPFEPTGLMLKYGDPLAA 897
               :|.:.|..|.||||.|.|.|.||.|..|.|
Human   727 ---SSAQQQMLQAQPPALQAPTGVTPAPSSAPP-------------------------------- 756

  Fly   898 KYGPPQDLKYPMPPVSQAGPADVKPYGGENLIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQ 962
              |.||   .|.|                        ||.|      ||.:.|   .|||.:.||
Human   757 --GTPQ---LPTP------------------------GPTP------SATAVP---PQGSPTASQ 783

  Fly   963 PPSMPPQPQQFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLH---Q 1024
            .|:   |||...:|.|..|:..      .|.:|||.     ||      .|.|||.| |.|   |
Human   784 APN---QPQAPTAPVPHTHIQQ------APALHPQR-----PP------SPHPPPHP-SPHPPLQ 827

  Fly  1025 PTPTSAGPPSLQHGLHPGHQHSQLSVASSIPPSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRP 1089
            |...|||.||                                  ||||..|.||.    ||...|
Human   828 PLTGSAGQPS----------------------------------APSHAQPPLHG----QGPPGP 854

  Fly  1090 HDL---PPSMHPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPP 1151
            |.|   |...||..|.|.          ||||        |..|.|.|.|.:.....|..:.|.|
Human   855 HSLQAGPLLQHPGPPQPF----------GLPP--------QASQGQAPLGTSPAAAYPHTSLQLP 901

  Fly  1152 RSMHDPQSSREPPTSQPSTTMAGSSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPMAIH 1216
            .|....| |::||..||..          |.|...||..            |||...|
Human   902 ASQSALQ-SQQPPREQPLP----------PAPLAMPHIK------------PPPTTPI------- 936

  Fly  1217 PHLAHLPPGHPAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLP 1281
                   |..||..|..||.|                   |:||.     |.|..:...||.
Human   937 -------PQLPAPQAHKHPPH-------------------LSGPS-----PFSMNANLPPPP--- 967

  Fly  1282 HSHASSAPLTAHSVASMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSS 1346

Human   968 ----------------------------------------------------------------- 967

  Fly  1347 AAAAAAAAAHRAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQS 1411
                       |..|.||:|                :|||
Human   968 -----------ALKPLSSLS----------------THHP------------------------- 980

  Fly  1412 PHMTPPPVSNASLM--ASPLSKMYAPQPGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPG 1474
            |...|||:   .||  :.||....|..||.......|||   |.:.||...|...|.|
Human   981 PSAHPPPL---QLMPQSQPLPSSPAQPPGLTQSQNLPPP---PASHPPTGLHQVAPQP------- 1032

  Fly  1475 GGIPQIGVHPGQSPYPHPLLHPSVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVM 1539
                                               |:...|:.||
Human  1033 -----------------------------------PFAQHPFVPG-------------------- 1042

  Fly  1540 AAHHAGLQGPPPQQMRQDEQNAAAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGMPPNKPPTP 1604
                    ||||.                                           .||..|.|.
Human  1043 --------GPPPI-------------------------------------------TPPTCPSTS 1056

  Fly  1605 KTPQGPG-GGMPPGMGGPGTPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDA 1668
            ..|.||| ...||..|.
Human  1057 TPPAGPGTSAQPPCSGA------------------------------------------------ 1073

  Fly  1669 LRAHAHSANSAGMGGGHHPTEPLP-IDIEPD-----PEPEIPSPTHNIPRGPSPEAKPDDTECHR 1727
                  :|:...:.||  .:.||| :.|:.:     .|||.|.|.   ||.||||....||..|.
Human  1074 ------AASGGSIAGG--SSCPLPTVQIKEEALDDAEEPESPPPP---PRSPSPEPTVVDTPSHA 1127

  Fly  1728 SQSAIFVRHIDRGDYNSCTRTDLIFKPVADSKLARKREERDRKL---------AEKERERRQQQQ 1783
            ||||.|.:|:||| ||||.||||.|.|:|.||||:||||...|.         .|:|||:.::::
Human  1128 SQSARFYKHLDRG-YNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKE 1191

  Fly  1784 QQQQQQQQQQAAAAQQAAQQA--------------KMKAELKPPYA-----------DTPALRQL 1823
            ::::::::::|..|.:|:..|              .|:...:||..           ||||||.|
Human  1192 REREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTL 1256

  Fly  1824 SEYARPHV------------AFSPVEQMVPYHHP----MGPMYRERELEEIKNAQAAAASQS--- 1869
            ||||||||            ..:|.:.::.||.|    :.|..|||||.|.:..:.....:.
Human  1257 SEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRE 1321

  Fly  1870 -----------RLDP-----HWMEYYRR----------GIHPSQFPLYANPAISQMERERLGIPP 1908
                       .|||     :.||::.|          |.||  |..: :|.::.:|||||.:..
Human  1322 RMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHP--FASF-HPGLNPLERERLALAG 1383

  Fly  1909 PHHVGLDP--------------GEHMIRLTRE---------------YHAHSHTHLHL------- 1937
            |.   |.|              .|.|..||.:               .|:|.|:||||
Human  1384 PQ---LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLH 1445

  Fly  1938 -----PLHPQPQPPEAGFQLPPNVGQYP-----RPNMLIPREPHSDVLLR--------------- 1977
                 |:||...|..||    |::.::|     .||.|:.:.||...:||
Human  1446 QGSAGPVHPLVDPLTAG----PHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGA 1506

  Fly  1978 ----MSYADQLQ--YLQAAEFQRQSLHDQY 2001
                ||.|.|||  :.|:||.||.::..|:
Human  1507 IPPPMSAAHQLQAMHAQSAELQRLAMEQQW 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	31/58 (53%)
		SANT	125..172	CDD:197842	33/46 (72%)
		SANT_MTA3_like	126..171	CDD:212559	31/44 (70%)
		Sec_Non_Glob	344..>440	CDD:275213	22/96 (23%)
RERE	NP_001036146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90
		BAH_MTA	102..307	CDD:240060	19/30 (63%)
		ELM2	286..336	CDD:279754	31/58 (53%)
		SANT_MTA3_like	395..440	CDD:212559	31/44 (70%)
		SANT	396..441	CDD:197842	32/44 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..495		11/57 (19%)
		ZnF_GATA	503..552	CDD:214648	13/99 (13%)
		ZnF_GATA	506..560	CDD:238123	14/70 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..1133		246/1413 (17%)
		Atrophin-1	568..1565	CDD:281189	358/1799 (20%)
		ICA69	627..793	CDD:282483	70/536 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1162..1246		16/83 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147633
Domainoid	1	1.000	178	1.000	Domainoid score	I3568
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2586
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S7094
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm41313
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5144
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.960