DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gug and MTA1-like

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster

Alignment Length:	716	Identity:	154/716 - (21%)
Similarity:	251/716 - (35%)	Gaps:	225/716 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESR---WSP-GVVADGDLLMFLRAA 66
            :||||||..:|. |:.|||.          |..||:|:|||..   |:| ..:.|..:..||..:
  Fly   229 KGEIRVGSRYQC-DIPAKLK----------DTATDDRKLEELESLVWTPEHSLTDRKIDQFLVVS 282

  Fly    67 RSMAAFQGMCD-------GGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKC--PV-SK 121
            ||:..|....|       ..|.....|||||.|..:|:::||...|...:::.:||..  || .:
  Fly   283 RSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEYSIEESMSSLVPSTGPVLCR 347

  Fly   122 GIDKKWTEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQ 186
            ...:.|:..|...|.:.|.::||:|..|.:|.||.|...:::|:||:||.|     :|..:::|.
  Fly   348 DEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYYYMWKTT-----DRYVQQKRV 407

  Fly   187 SA------LRRNRVTRANNSNSNTPPKKEDTPEPQTATTA-----TAAATAASETASRSSPAVSK 240
            .|      |::..:.:.||:....          .|:|.|     ......:::.:|...|
  Fly   408 KAVEAELKLKQVYIPQYNNNGKGN----------GTSTKAGGGIYNGTTNGSTDLSSNGKP---- 458

  Fly   241 EENSSLTEDDASECDSDSSLTHKRDESPSRMRTRNKQQNNNSSTSSGNNTA---------GNGGG 296
                         |:|..:             |::.|.|   |.|||::|:         ....|
  Fly   459 -------------CESCGT-------------TKSSQWN---SVSSGHSTSRLCLSCWEYWRRYG 494

  Fly   297 NATSISSGSTGGGAAGGNSSSKDQSANAVANGKRPKRGSETPDVSGGASVDSPKTPTKAVAESSA 361
            :..|.:.|..|.|.|      |.:|::|.:        :.|..::|.|:     |||..|..:..
  Fly   495 SMKSATKGDAGEGDA------KKKSSSAAS--------TPTATLAGLAT-----TPTAVVDLNDD 540

  Fly   362 NKRKGGKQDTPNK--------------KKRTEQESNEPSAHEENAIKEKRKRPDSPVES-----M 407
            .|    ..|..|:              |.:|....:...|| ..||.....||.....:     .
  Fly   541 EK----ISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAH-GIAISSGSPRPIMKTRTAFYLHT 600

  Fly   408 NSDSRPDSVLDDGESNTTDTTTAEQQSTKDSKETVSCKEEREMVTNDLEAKAEEKAIKAEALAED 472
            |..:|....:       ..:....:::.:.|...::....::..||.:..|::.:..|...|...
  Fly   601 NPMTRVARAI-------CRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAEIKKLLLLKPK 658

  Fly   473 SKDSAIK------------------NMDEETNIQA-------PSSADTSLVDGPNPNALPSPVAA 512
            .:.|..|                  ...::..:.|       |.:.|.|||....||..|..||.
  Fly   659 DRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPKPPKAPDGSLVYDRVPNKSPDVVAV 723

  Fly   513 PITMK---VPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQSQQ 574
            |...:   :||.||      |..||.|.|
  Fly   724 PADKELTIIPTQAT------STIRKRAHE------------------------------------ 746

  Fly   575 QMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHSAG 639
              .|||....:...||.||:      |.|.:|.|.:.|    ..|:.....:....:...:|...
  Fly   747 --DQQLNGTEVTIVPSGPPA------KRPNKDPMPSHC----PSPEQFAAMMAASGQPLSRHHLN 799

  Fly   640 G 640
            |
  Fly   800 G 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	21/62 (34%)
		SANT	125..172	CDD:197842	17/46 (37%)
		SANT_MTA3_like	126..171	CDD:212559	16/44 (36%)
		Sec_Non_Glob	344..>440	CDD:275213	19/114 (17%)
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	13/34 (38%)
		ELM2	232..284	CDD:279754	21/62 (34%)
		SANT_MTA3_like	352..397	CDD:212559	16/44 (36%)
		SANT	353..398	CDD:197842	17/44 (39%)
		ZnF_GATA	458..508	CDD:238123	15/82 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D802091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920