DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and ATN1

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	NP_001007027.1	Gene:	ATN1 / 1822	HGNCID:	3033	Length:	1190	Species:	Homo sapiens

Alignment Length:	1755	Identity:	397/1755 - (22%)
Similarity:	546/1755 - (31%)	Gaps:	788/1755 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 TKDSKETVSCKEEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADTSLVD 499
            |:.:|:::|.:..|:.     ||....:.:::...|                  :|....||..|
Human     3 TRQNKDSMSMRSGRKK-----EAPGPREELRSRGRA------------------SPGGVSTSSSD 44

  Fly   500 GPNPNALPSPVAAPITMKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQ 564
            |                           .|...|:.|.:......|.|::.|:..:  :|:|..:
Human    45 G---------------------------KAEKSRQTAKKARVEEASTPKVNKQGRS--EEISESE 80

  Fly   565 QQHMQQQSQQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATC--NQNSNEPQDL----- 622
            .:......:.:.:|:|     |:|.|  ||:.         ||:|...  :..|::|:|:
Human    81 SEETNAPKKTKTEQEL-----PRPQS--PSDL---------DSLDGRSLNDDGSSDPRDIDQDNR 129

  Fly   623 KVKIEIKNEDALKH---SAGGLPPSGPCAP--PSALHPLSGAPVESGQEPLHLQHMPHGQVTTQP 682
            .....|.:..::::   |:.|| ..||..|  |..|.|.|..|.:|..........||..||
Human   130 STSPSIYSPGSVENDSDSSSGL-SQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVT--- 190

  Fly   683 PPGYLIDGQLKYGP----------SGQGVPPQPPQLHSDAAGGVSGAPP------------GAPT 725
            |.||       :.|          :..|.||..|||:....|||...||            |.|.
Human   191 PTGY-------HAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPN 248

  Fly   726 TPQKYPPEMEMKFAPQDLKYPPPPPLDALKYSQEMQAAAAAAAAAGKYDMKYMMEQQGKYNVELS 790
            ..:::|              ||..|:           :.:::.|:|
Human   249 GGKQHP--------------PPTTPI-----------SVSSSGASG------------------- 269

  Fly   791 AAHQPPSKPGYQDSLKIPDIKPGFGHLPHNVGSPLDAAH---KYGPPPTSQESQQQQPQPPAHQV 852
               .||:||        |....|.|:|| :...|.:..|   ...|||..:........||.
Human   270 ---APPTKP--------PTTPVGGGNLP-SAPPPANFPHVTPNLPPPPALRPLNNASASPPG--- 319

  Fly   853 PPGATPPPGIAMPKPHYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYGP---PQDLKYPMPPVSQ 914
             .||.|.|| .:|.||        .:|:...        |.|...:.||   |.  .:.:||.|.
Human   320 -LGAQPLPG-HLPSPH--------AMGQGMG--------GLPPGPEKGPTLAPS--PHSLPPASS 364

  Fly   915 AGPADVKPYGGENLIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPPSMPPQPQQFQSPHPS 979
            :.||                 ||...|..:|:.|:....|..|:|:|.....|........||..
Human   365 SAPA-----------------PPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSF 412

  Fly   980 PHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTSAGPPSLQHGLHPGHQ 1044
            |...|.:....||.....:|    |..|....||.||||           .|........|||
Human   413 PPPTSLSVSNQPPKYTQPSL----PSQAVWSQGPPPPPP-----------YGRLLANSNAHPG-- 460

  Fly  1045 HSQLSVASSIPPSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPPSMHPHAPMPLSLQGH 1109
                    ..||         ||.|.|..||                 |.|.|.|
Human   461 --------PFPP---------STGAQSTAHP-----------------PVSTHHH---------- 481

  Fly  1110 PQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPPRSMHDPQSSREPPTSQPSTTMAG 1174
                      |..|||||||||||              ||..:..|.                 |
Human   482 ----------HHQQQQQQQQQQQQ--------------QQQQQQQHH-----------------G 505

  Fly  1175 SSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPMAIHPHLAHLPPGHPAHAALAHPGHHL 1239
            :|||  |||...||     ||.|  ||...     .||.|:.|.|..|.|         :|
Human   506 NSGP--PPPGAFPH-----PLEG--GSSHH-----AHPYAMSPSLGSLRP---------YP---- 543

  Fly  1240 LSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPHSHASSAPLTAHSVASMTSTSMS 1304
                                ||               |:|||..|:
Human   544 --------------------PG---------------PAHLPPPHS------------------- 554

  Fly  1305 LTTSTVPSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSSAAAAAAAAAHRAASPASSVSSLS 1369
                              |:|.|..||:||                          |.||.|:.|
Human   555 ------------------QVSYSQAGPNGP--------------------------PVSSSSNSS 575

  Fly  1370 RQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQSPHMTP---PPVSNASLMASPLSK 1431
            ..:.....|.|    |||.|                    |.|...|   |||...:..::.||.
Human   576 SSTSQGSYPCS----HPSPS--------------------QGPQGAPYPFPPVPTVTTSSATLST 616

  Fly  1432 MYAPQPGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPGGGIPQIGVHPGQSPYPHPLLHP 1496
            :.|
Human   617 VIA-------------------------------------------------------------- 619

  Fly  1497 SVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGPPPQQMRQDEQNA 1561
            :|..||..:...||       ||.|.|.|..|.||....|.
Human   620 TVASSPAGYKTASP-------PGPPPYGKRAPSPGAYKTAT------------------------ 653

  Fly  1562 AAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGMPPNKPPTPKTPQGPG--GGMPPGMGG---P 1621
                                           |.|..|..||:.:|...||  |..||...|   |
Human   654 -------------------------------PPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKP 687

  Fly  1622 GTPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGMGGGHH 1686
            |:|| :.||..|.:...|.|..||  .|.||..|.|  |..|
Human   688 GSPT-VGPGPLPPAGPSGLPSLPP--PPAAPASGPP--LSAT----------------------- 724

  Fly  1687 PTEPLPIDIEPDPEPEIPSPTHNIP--RGPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCTRTD 1749
                   .|:.:|..|..:|...:|  |.|||..|..|...|.||||.|.:|:||| :|||.|:|
Human   725 -------QIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRG-FNSCARSD 781

  Fly  1750 LIFKPVADSKLARK---------REERDRKLAEKERERRQQQQQQQQQQQQQQAAAAQQAAQQAK 1805
            |.|.|:..||||:|         ||...|...||||||.::::::::::::::...:.:.||:.:
Human   782 LYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGR 846

  Fly  1806 MKAELK--------------------PPY--ADTPALRQLSEYARPHVAFSPVEQMVPYHHPMG- 1847
            ...|..                    |||  .||||||.||||||||| .||..:..|::.|:|
Human   847 APVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHV-MSPGNRNHPFYVPLGA 910

  Fly  1848 -----------------PMYRERELE--------------EIKNAQAAAASQSRLDP-H-----W 1875
                             |..||||.|              |:|        .|.|:| |     .
Human   911 VDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVK--------PSELEPLHGVPGPG 967

  Fly  1876 MEYYRR-----------GIHPSQFPLYANPAISQMERERLGI-------PPPHH----------- 1911
            ::.:.|           |:||  ||.:  |::..:|||||.:       |...:
Human   968 LDPFPRHGGLALQPGPPGLHP--FPFH--PSLGPLERERLALAAGPALRPDMSYAERLAAERQHA 1028

  Fly  1912 -----VGLDP--GEHMIRLTREYHAHSHTHLHLPLHPQPQPPEAGFQLPPNVG-----------Q 1958
                 :|.||  ...|:.:|..:|.|||.|.||.||.|.....|...:.|.:.           .
Human  1029 ERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIP 1093

  Fly  1959 YPR---PNMLIPREPHSDVLLR------------------MSYADQLQ--YLQAAEFQRQSLHDQ 2000
            ||.   ||.|:|...|.:.:||                  ||.|.|||  :.|:||.||.:|..|
Human  1094 YPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQ 1158

Fly 2001 2000
Human 1159 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754
		SANT	125..172	CDD:197842
		SANT_MTA3_like	126..171	CDD:212559
		Sec_Non_Glob	344..>440	CDD:275213	1/4 (25%)
ATN1	NP_001007027.1	Atrophin-1	1..1189	CDD:281189	397/1755 (23%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12464607	16..32		3/20 (15%)
		polyglutamine repeat	484..502		13/31 (42%)
		Involved in binding BAIAP2	517..567		28/172 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..767		59/241 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	785..862		18/76 (24%)
		Required for interaction with FAT1. /evidence=ECO:0000269\|PubMed:19131340	879..894		13/14 (93%)
		Nuclear export signal	1033..1041		3/7 (43%)
		HX repeat. /evidence=ECO:0000269\|PubMed:30827498	1049..1065		8/15 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147634
Domainoid	1	1.000	178	1.000	Domainoid score	I3568
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2586
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm41313
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.980