DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gug and egl-27

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	NP_741012.1	Gene:	egl-27 / 174121	WormBaseID:	WBGene00001194	Length:	1129	Species:	Caenorhabditis elegans

Alignment Length:	905	Identity:	202/905 - (22%)
Similarity:	319/905 - (35%)	Gaps:	242/905 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASTQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAAR 67
            |||...||||...|     |.||   |::...:..::|..||   .:.|..:..|:...:::.||
Worm   220 ASTHYAIRVGTSFQ-----ATLP---PMAECSVGDDSDRDEL---LYRPNSIESGEEEDYIKLAR 273

  Fly    68 SMAAF----QGMCDGGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGID-KKW 127
            ....:    ..|.|.......|..| |.....|:..||.|||....||..|....:....| ...
Worm   274 CYRTYTLSGNHMLDSQKNARSLQVS-DLLMDEAIIQLHRSGYKIDDALSELNANDIILTTDVDNM 337

  Fly   128 TEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRN 192
            |:|:.|||.||::|.||||.|||::||||....:||.:||||||||.|  .:|.:..|
Worm   338 TQDDAKKFAKGIKQLGKNFSRIHRELLPHHSREQLVSYYYLWKKTPEA--TKPKQAAR------- 393

  Fly   193 RVTRANNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSP----------AVSKE---ENS 244
               |.|.::...|.|::......|:|......:|:......:.|          |.||:   .|.
Worm   394 ---RVNPTSIKRPTKEKVKASRPTSTEYLDFDSASESDVENNGPSGRACHHCYGAESKDWHHANG 455

  Fly   245 SLTEDDASECDSDSSLTHKR------------------------DESPSRMRTR--NKQQNNNSS 283
            .|.      | :|..|.:|:                        ||..|.:|||  .|:|...:.
Worm   456 LLL------C-TDCRLHYKKYGQLRQIANRPSQVPACLFKRSNSDEEESGVRTRAGKKEQRRRTP 513

  Fly   284 TSSGN-------NTAGNGGGNATSIS------SGSTGGGAAGGNSSSKDQSANAVANGKRPKRGS 335
            :|...       :|..||..|.|:..      :||.       ..:.|....|.|.|.......|
Worm   514 SSMSETPDRRSPSTVSNGAPNLTAEETPTKKLNGSV-------KRAPKRPLHNGVINNVEKSNSS 571

  Fly   336 ETPDVSGGASVDSPKTPTKAVAESSANKRKGGKQDTPNKKKRTEQESNEPSAHEENAIKEKR--- 397
            |.|        .||.||...:.....|.. |.:..|||.:..:::...|||..:::..:|.:
Worm   572 EEP--------ASPTTPPPTLTNGLTNGH-GPESSTPNGETISKRMKVEPSYDDDDDEEEGKMTI 627

  Fly   398 -KRPDSPVESMNSDSRPDSVLD-----DGESNTTDTTTAEQQSTKDSKETVSCKEEREMVTNDLE 456
             :..|.|:..:|...:.:||.:     :|       |..::...:....|.:|..|.|   |::
Worm   628 DEGDDDPMPVLNGFKKEESVEEIKLELNG-------TIKKENGVETDPTTPTCSMEAE---NEV- 681

  Fly   457 AKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADT----SLVDGPNPNAL----------P 507
              .|..|:.:..:.:::......::.::.|::..|..||    |.|:....||:          |
Worm   682 --CETPAVVSVEIRDETNGETNSDLKDDENVEPDSPEDTFELGSNVEFETKNAMFVRSIVRSCGP 744

  Fly   508 SPVAAPITMKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQS 572
            ......:..|:......|   .|:..||..:|:...:...:..:|:|..:.::..:|||  .|.:
Worm   745 RCARTDLIFKIKVGGVWE---KSIKEKEERKKVHLQNQRIQDSEKVAIQQNQIKKEQQQ--SQPT 804

  Fly   573 QQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHS 637
            .||:.||.|                               .||:...|.|:..:      .|.|
Worm   805 PQQIHQQQA-------------------------------QQNAQHLQQLQQAV------MLGH- 831

  Fly   638 AGGLPPSGPCAPPSALHPLSGAPVESGQEP--LHLQHMPHGQ-------------VTTQPPPGYL 687
                      .||..|..:  .|.:.|.:|  :.:|.|..||             ...|....:.
Worm   832 ----------LPPEVLRQM--MPPQFGVDPTAILMQQMMAGQQSQGVNAAFQHQMALQQQLEAHQ 884

  Fly   688 IDGQLKYGPSGQG---VPPQPPQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQDLKYPPPP 749
            :..||......|.   ...|..|.|:        |........|:...|.|.:...|.      .
Worm   885 VQFQLMMAHQHQQKMIAEQQQQQRHA--------AAQQLREREQREQRERERERQHQQ------Q 935

  Fly   750 PLDALKYSQEMQAAAA---------------AAAAAGKYDMKYMMEQQGKYNVELSAAHQ 794
            ...||...|:..||||               |.:||.:.|:..:||...:...:...|.|
Worm   936 AQQALHQQQQQHAAAAANQLNPAMMQMMALMANSAASQQDIARLMEMAAQQQQQQQQAAQ 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	15/58 (26%)
		SANT	125..172	CDD:197842	26/46 (57%)
		SANT_MTA3_like	126..171	CDD:212559	25/44 (57%)
		Sec_Non_Glob	344..>440	CDD:275213	20/104 (19%)
egl-27	NP_741012.1	BAH_MTA	86..247	CDD:240060	12/34 (35%)
		ELM2	226..274	CDD:279754	15/58 (26%)
		SANT	335..382	CDD:197842	26/46 (57%)
		SANT_MTA3_like	336..381	CDD:212559	25/44 (57%)
		ZnF_GATA	434..483	CDD:214648	10/55 (18%)
		ZnF_GATA	438..488	CDD:238123	9/56 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I2874
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5144
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110