DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and Atn1

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	NP_031907.2	Gene:	Atn1 / 13498	MGIID:	104725	Length:	1175	Species:	Mus musculus

Alignment Length:	1415	Identity:	371/1415 - (26%)
Similarity:	498/1415 - (35%)	Gaps:	543/1415 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   841 QQQQPQPPAHQVPPGATPPPGIAMPKP--HYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYGPPQ 903
            :::.|.|.......|...|.|::....  ..:...||....|..||:.       |.|:|.|..:
Mouse    17 KKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARIEEPSA-------PKASKQGRSE 74

  Fly   904 DL------------------KYPMPPVSQAGPADVKPYGGENLIKSSPYGPPPESPIDASARST- 949
            ::                  :.|.|    ..|:|:....|.::   :..|......||...|||
Mouse    75 EISESESEETSAPKKTKTEQELPRP----QSPSDLDSLDGRSI---NDDGSSDPRDIDQDNRSTS 132

  Fly   950 -----PG---QDSQGSNSNSQPPSMPPQPQQFQSPHPSP-HMPSPAGGGLPPGMHPQNLIHGPPP 1005
                 ||   .||..|:..||.|:.|        .||.| ..|||                 |||
Mouse   133 PSIYSPGSVENDSDSSSGLSQGPARP--------YHPPPLFPPSP-----------------PPP 172

  Fly  1006 GAA-----GGSGPQPPPPPTSLHQP--TPTS---AGPPSLQHGLHPGHQHSQLSVASSIPPSSIG 1060
            .:.     .|..|.|..|||..|.|  .|||   .|||.                         |
Mouse   173 DSTPRQPESGFEPHPSVPPTGYHAPMEPPTSRLFQGPPP-------------------------G 212

  Fly  1061 IPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPPSMHPHAPMPLSLQGHPQHGHGLPPSHTSQQQ 1125
            .|||         ||.|:|.....|:                   |.|.|....|
Mouse   213 APPT---------HPQLYPGNASGGV-------------------LSGPPMGPKG---------- 239

  Fly  1126 QQQQQQQQPGGPAGTVRTPSPAQQ-PPRSMHDPQSSR----EPPTSQPSTTMAGSSGPGGPPPQQ 1185
                     |..|.:|..||..:| ||.:...|.||.    .||...||..:.|.|.|..|||..
Mouse   240 ---------GAAASSVGAPSGGKQHPPPTTPIPISSSGASGAPPAKPPSAPVGGGSLPSAPPPAS 295

  Fly  1186 SPHAHRTSPLPGLAGSGPPPPGL--IGHPMAIHPHLAHLP-PGHPAHAALAHPGHHLLSHSIAGL 1247
            .||.     .|.|    ||||.|  :.:..|..|.:...| |||       .|..|.:...::||
Mouse   296 FPHV-----TPNL----PPPPALRPLNNASASPPGMGAQPIPGH-------LPSPHAMGQGMSGL 344

  Fly  1248 --GPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPHSHASSAPLTAHSVASMTSTSMSLTTSTV 1310
              ||..|| .|...|..|   |.::.|...||...|:|.:||:       |:.:|:|.|.:.|..
Mouse   345 PPGPEKGP-TLAPSPHPL---PPASSSAPGPPMRYPYSSSSSS-------AAASSSSSSSSASQY 398

  Fly  1311 PSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSSAAAAAAAAAHRAASPASSVSSLSRQSPLH 1375
            |:   |:|.||.                |...|                 |.:|: |:|.|.|.:
Mouse   399 PA---SQALPSY----------------PHSFP-----------------PPTSM-SVSNQPPKY 426

  Fly  1376 PVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQSPHMTPPPVSNASLMAS----PLSKMYAPQ 1436
            ..|..|      |.|:.:                |.|   |||.....|:|:    |     .|.
Mouse   427 TQPSLP------SQAVWS----------------QGP---PPPPPYGRLLANNNTHP-----GPF 461

  Fly  1437 PGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPGGGIPQIGVHPGQS------PYPHPLLH 1495
            |...|..|:.|      |:|....|.|.             ||...|.|.|      .|||||..
Mouse   462 PPTGGQSTAHP------AAPTHHHHQQQ-------------PQQQHHHGNSGPPPPGAYPHPLES 507

  Fly  1496 PSVFYSPHHHPFN-SPY--GYAPYGPGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGPPPQQMRQD 1557
            .:   |.|.||:| ||.  ...||.|| ||:: |||. ||      ::.:.||..|||     ..
Mouse   508 SN---SHHAHPYNMSPSLGSLRPYPPG-PAHL-PPPH-GQ------VSYNQAGPNGPP-----VS 555

  Fly  1558 EQNAAAAAAQAAAEKQHQAA-------------------AAAAAQQHKAPQQQQPGG----MPPN 1599
            ..|::.:::||:....|.::                   ::|......|.....|.|    .||.
Mouse   556 SSNSSGSSSQASYSCSHPSSSQGPQGASYPFPPVPPVTTSSATLSTVIATVASSPAGYKTASPPG 620

  Fly  1600 KPPTPKTPQGPGG---GMPPGMGGPGTP----TGLPPG-------AYPGSHMPGYPQG-----PP 1645
            .|...|....||.   ..|||. .||:|    ||.|||       |.||:..||.|..     ||
Mouse   621 PPQYSKRAPSPGSYKTATPPGY-KPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPP 684

  Fly  1646 HG---------SPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGMGGGHHPTEPLPIDIEPDPEP 1701
            .|         .|.||..|.|  |..|                              .|:.:|..
Mouse   685 AGPSSLSSLPPPPAAPTTGPP--LTAT------------------------------QIKQEPAE 717

  Fly  1702 EIPSPTHNIP--RGPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCTRTDLIFKPVADSKLARK- 1763
            |...|...:|  |.|||..|..|...|.||||.|.:|:||| :|||.|:||.|.|:..||||:|
Mouse   718 EYEPPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRG-FNSCARSDLYFVPLEGSKLAKKR 781

  Fly  1764 --------REERDRKLAEKERERRQQQQQQQQQQQQQQAAAAQQAAQQAKMKAELK--------- 1811
                    ||...|...||||||.::::::::::::::...:.:.||:.:...|..
Mouse   782 ADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRP 846

  Fly  1812 -----------PPY--ADTPALRQLSEYARPHVAFSPVEQMVPYHHPMG---------------- 1847
                       |||  .||||||.||||||||| .||..:..|::.|:|
Mouse   847 PFEPGSAVATVPPYLGPDTPALRTLSEYARPHV-MSPGNRNHPFYVPLGAVDPGLLGYNVPALYS 910

  Fly  1848 --PMYRERELE--------------EIKNAQAAAASQSRLDP-H-----WMEYYRR--------- 1881
              |..||||.|              |:|        .|.|:| |     .::.:.|
Mouse   911 SDPAAREREREARERDLRDRLKPGFEVK--------PSELEPLHGVPGPGLDPFPRHGGLALQPG 967

  Fly  1882 --GIHPSQFPLYANPAISQMERERLGI-------PPPHH----------------VGLDP--GEH 1919
              |:||  ||.:  |::..:|||||.:       |...:                :|.||  ...
Mouse   968 PPGLHP--FPFH--PSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQ 1028

  Fly  1920 MIRLTREYHAHSHTHLHLPLHPQPQPPEAGFQLPPNVG-----------QYPR---PNMLIPREP 1970
            |:.:|..:|.|||.|.||.||.|.....|...:.|.:.           .||.   ||.|:|...
Mouse  1029 MLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPL 1093

  Fly  1971 HSDVLLR------------------MSYADQLQ--YLQAAEFQRQSLHDQ 2000
            |.:.:||                  ||.|.|||  :.|:||.||.:|..|
Mouse  1094 HENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQ 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754
		SANT	125..172	CDD:197842
		SANT_MTA3_like	126..171	CDD:212559
		Sec_Non_Glob	344..>440	CDD:275213
Atn1	NP_031907.2	Atrophin-1	1..1174	CDD:281189	371/1415 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..595		201/818 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	16..32		2/14 (14%)
		Involved in binding BAIAP2. /evidence=ECO:0000250	503..553		24/61 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..752		51/176 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..847		18/76 (24%)
		Required for interaction with FAT1. /evidence=ECO:0000250	864..879		13/14 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	913..932		6/18 (33%)
		Nuclear export signal. /evidence=ECO:0000250	1018..1026		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837714
Domainoid	1	1.000	185	1.000	Domainoid score	I3374
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3476
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm43372
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13859
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980