Protein Alignment Gug and MTA1-like

DIOPT Version :10

• Sequence 1: NP_001261581.1
• Gene: Gug / 46156
• FlyBaseID: FBgn0010825
• Length: 2007
• Species: Drosophila melanogaster
• Sequence 2: XP_313620.6
• Gene: MTA1-like / 1274488
• VectorBaseID: AGAMI1_013634
• Length: 1091
• Species: Anopheles gambiae
• Alignment Length: 1406
• Identity: 250/1406 - (17%)
• Similarity: 390/1406 - (27%)
• Gaps: 596/1406 - (42%)

  Fly     6 QGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESR---WSP-GVVADGDLLMFLRAA 66
            :||||||..:|.:......|.           |.|||.|||..   |:| ..:.|..:..||..:
Mosquito   192 KGEIRVGARYQTDLQQMLKPG-----------EKDERNLEELETLVWTPQHSLTDKKIDQFLVVS 245

  Fly    67 RSMAAFQGMCD-------GGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKC--PV-SK 121
            ||:..|....|       ..|.....|||||.|..:|:|.||...|....|:.:||..  || .:
Mosquito   246 RSVGTFARALDCTSSVKQPSLHMSAAAASRDITLFHAMDTLHKHNYSIETAMCSLVPSSGPVLCR 310

  Fly   122 GIDKKWTEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQ 186
            ...::|:..|...|...|.::||:|..|..|.||.|....:||:||:||.|     :|..:::|.
Mosquito   311 DEMEEWSASEANLFEDALDKYGKDFNDIRNDFLPWKTLKSIVEYYYMWKTT-----DRYVQQKRV 370

  Fly   187 SALRRNRVTRANNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDA 251
            .|:.                                   |.|:......|..:|...:.:|
Mosquito   371 KAVE-----------------------------------AESKLKQVYIPNYTKPSPALIT---- 396

  Fly   252 SECDSDSSLTHKRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSS 316
                                       |||....:||:   |||.....|.|.:....:....:|
Mosquito   397 ---------------------------NNNKGILNGNS---NGGSVDMMIYSSTKACESCATMAS 431

  Fly   317 SKDQSANAVANGKRP--------KRGSETPDVSGGASVDS------PKTPTKAVAESSANKRKGG 367
            .:..|...|....|.        ||       .||..|.|      ...|...:..||:|
Mosquito   432 PQWYSWGPVHLNNRLCQNCWTYWKR-------YGGLKVASRLADNGEVDPVATINTSSSN----- 484

  Fly   368 KQDTPNKKKRTEQESNEPSAHEENAIKEKRKRPDSPVE---SMNSDSRPDSVLDDGESNTTDTTT 429
                                  .:.:..|::.|.|.::   ::.:.|.|..    |....|..|.
Mosquito   485 ----------------------ASPVSLKKRNPGSDIDDDLTIVASSGPIG----GLGGATVATA 523

  Fly   430 A-------EQQSTKDSKETVSCKEEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNI 487
            :       ...|.......|:|.:|.::                       |....::..:...|
Mosquito   524 SPGGLSNHRPHSPSFKCSIVNCGKEFKL-----------------------KAHLARHYAQAHGI 565

  Fly   488 QAPSSADTSLVDGPNPNALPSPVAAPITMKVPTIATVE-ALNASVDRK--EAIEKMESCDSDPEM 549
            |..|.:             |.|:     ||..|...:. .|...:.|:  ..|.:.:.....|..
Mosquito   566 QIRSGS-------------PRPI-----MKTRTAFYLHTTLTTRLSRRLCRHIIRSKKAARQPSY 612

  Fly   550 LKKLATIKQEVSPQQQQHMQQQSQQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQ 614
            ...:|::|||.:                                               :|...:
Mosquito   613 AINIASVKQEFA-----------------------------------------------NAEAGK 630

  Fly   615 NSNEPQDLKVKIEIKNEDALKHSAGGLPPSGPCAPPSALHPLSGAPVESGQEPLHL---QHMPHG 676
            ::::.:.| :....|:..::...|..|                |.|..|..|.|.|   ::||..
Mosquito   631 SASDIRRL-LTFRKKDRGSVTQIANRL----------------GNPGVSVNEWLVLTPKENMPKP 678

  Fly   677 QVTTQPPPGYLIDGQLKYGPSGQGVPPQPPQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQ 741
            .|...|.|....||.|.|    ..:|.:         |..:|.||.|.|:|
Mosquito   679 DVVAFPKPPKAPDGTLLY----DRIPNK---------GEEAGKPPNAVTSP-------------- 716

  Fly   742 DLKYPPPPPLDALKYSQEMQAAAAAAAAAGKYDMKYMMEQQGKYNVELSAAHQPPSKPGYQDSLK 806
                                    ||...|                  .:|..|.:..|...|..
Mosquito   717 ------------------------AAGILG------------------GSATLPGTVGGALGSKL 739

  Fly   807 IPDIKPG---------FGHLPHNVGSPLDAAHKYGPPPTSQESQQQQPQPPAHQVPPGATPPPGI 862
            .|.:..|         .|...::||:...|.                       ...|:|...|:
Mosquito   740 APLVGSGGLAVTPIVVSGTNSNSVGTACSAV-----------------------AGSGSTGSTGV 781

  Fly   863 AMPKPHYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYGPPQDLKYPMPPVSQAGPADVKPYGGEN 927
            .                     ||.:...|.|....:........|     ..||.......|..
Mosquito   782 T---------------------TGTIANSGMPAINLHASAMSTSSP-----PRGPTPTGSSSGAT 820

  Fly   928 LIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPPSMPPQPQQFQSPHPSPHMPSPAGGGLPP 992
            .:|..||                 :|:.|.::...||:..|.    :.|.||
Mosquito   821 SLKRRPY-----------------EDANGIDATVAPPAKRPN----KDPRPS------------- 851

  Fly   993 GMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTP----------TSAGPPSLQHGLHPGHQHSQ 1047
                                          |:|||          .|||.|..:|     |.:.:
Mosquito   852 ------------------------------HRPTPEQYAAMIAAAQSAGQPLPRH-----HMNGK 881

  Fly  1048 LSVASSIPPSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPPSMHPHAPMPLSLQGHPQH 1112
            ..:|......| |....:|.                      :|.|..:.
Mosquito   882 PKIAQMARTGS-GRKQVISW----------------------NDAPDDVF--------------- 908

  Fly  1113 GHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPPRSMHDPQSSREPPTSQPSTTMAGSSG 1177
                   :.|.:..::.:::.|     .|.....|::|.|::|
Mosquito   909 -------YRSTKAGRKLRREIP-----IVELRRAARKPWRNLH---------------------- 939

  Fly  1178 PGGPPPQQSPHAHRTSPLPGLAGSGPPP-PGLIGHPMAI-------HPHLAHLPPGHPAHAALA- 1233
                 |:.|.......|:..:..|.|.. ...:||...:       ||..|:|.....|.||||
Mosquito   940 -----PKYSAIVAALLPVASVTPSLPAQLTAQLGHAAQLAAASAVQHPTSANLNLNLAAAAALAG 999

  Fly  1234 -HPGHHLLSHSIAG-LGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPHSHASSAPLTAHSVA 1296
             ||.....:.:::| ||..||.:.     ..:||:|  :||          ..::...|.:..|.
Mosquito  1000 VHPLSAASTLALSGTLGAAGGTVI-----SPVGGVP--SLS----------GGSTGTSLVSSGVT 1047

  Fly  1297 SMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSV 1337
            .:|::|.|...|.             ..||||||.||...|
Mosquito  1048 GLTNSSSSNNNSG-------------NSSSSGGGGSGASGV 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:460214	18/62 (29%)
		SANT_MTA3_like	126..171	CDD:212559	17/44 (39%)
		PHA03247	<856..1289	CDD:223021	72/453 (16%)
		Atrophin-1	<1408..>1857	CDD:460830
MTA1-like	XP_313620.6	None