DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and Rere

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	XP_008762420.1	Gene:	Rere / 116665	RGDID:	629475	Length:	1567	Species:	Rattus norvegicus

Alignment Length:	2175	Identity:	521/2175 - (23%)
Similarity:	674/2175 - (30%)	Gaps:	1094/2175 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARS 68
            ||||||||||.||     |||||..|..|...|..|...||.   |.|| |:|.||||:||||||
  Rat   280 STQGEIRVGPSHQ-----AKLPDLQPFPSPDGDTVTQHEELV---WMPG-VSDCDLLMYLRAARS 335

  Fly    69 MAAFQGMCDGG-LEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDET 132
            ||||.|||||| .||||:||||||||:|||:.||:|.||.|||||.|||.||.|.|:|.|||||.
  Rat   336 MAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESSYDAGKALQRLVKKPVPKLIEKCWTEDEV 400

  Fly   133 KKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRA 197
            |:|:|||||:|||||||.|:|||:|:|.||:.|||.|||||.|.::|.|||.|:.|:.|...||.
  Rat   401 KRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRT 465

  Fly   198 NNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDASECDSDSSLTH 262
            .::..|||.:                           .|:....:.||.:|||....||:..|.
  Rat   466 ASTPVNTPSR---------------------------PPSSEFLDLSSASEDDFDSEDSEQELK- 502

  Fly   263 KRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSSSKDQSANAVAN 327
                                             |.|......:|          |||..     :
  Rat   503 ---------------------------------GYACRHCFTTT----------SKDWH-----H 519

  Fly   328 GKRP------------KRGSETPDVSGGASVDSPKTPTKAVAESSANKRKGGKQDTPNKKKRTEQ 380
            |.|.            |:..|.|.:.  ..||.|....|.|.|.  :....||.....::.|...
  Rat   520 GGRENILLCTDCRIHFKKYGELPPIE--KPVDPPPFMFKPVKEE--DDGLSGKHSMRTRRSRGSM 580

  Fly   381 ESNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQQSTKDSKETVSCK 445
            .:....         ::|:|.||      |.|...|.:|..|:..::.:|...|:.|||
  Rat   581 STLRSG---------RKKQPASP------DGRASPVNEDVRSSGRNSPSAASTSSNDSK------ 624

  Fly   446 EEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADTSLVDGPNPNALPSPV 510
                                    ||..|.|| |.:.||                         .
  Rat   625 ------------------------AEAVKKSA-KKVKEE-------------------------A 639

  Fly   511 AAPITMKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQSQQQ 575
            |:|:.                :.|...||:.|...|.:......|..||:|.
  Rat   640 ASPLK----------------NTKRQREKVASDTEDTDRATSKKTKTQEISR------------- 675

  Fly   576 MQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHSAGG 640
                      |..||....||        .||.... ::.|::|:|:
  Rat   676 ----------PNSPSEGEGES--------SDSRSVN-DEGSSDPKDI------------------ 703

  Fly   641 LPPSGPCAPPSALHPLSGAPVESGQEPLHLQHMPHGQVTTQPPPGYLIDGQLKYGPSGQGVPPQP 705

  Rat   704 ----------------------------------------------------------------- 703

  Fly   706 PQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQDLKYPPPPPLDALKYSQEMQAAAAAAAAA 770
                                                               .|:.::.:
  Rat   704 ---------------------------------------------------DQDNRSTS------ 711

  Fly   771 GKYDMKYMMEQQGKYNVELSAAHQPPSKPGYQDSLKIPDIKPGFGHLPHNVGSPLDAAHKYGPPP 835
                                     ||.|..||:....|
  Rat   712 -------------------------PSIPSPQDNESDSD-------------------------- 725

  Fly   836 TSQESQQQQPQPPAHQVPPGATPPPGIAMPKPHYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYG 900
            :|.:.|..|.||||.|.|.||...|..|
  Rat   726 SSAQQQMLQTQPPALQAPSGAASAPSTA------------------------------------- 753

  Fly   901 PPQDLKYPMPPVSQAGPADVKPYGGENLIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPPS 965
            ||...:.|.|                        ||.|      ||.:.|   .|||.:.||||:
  Rat   754 PPGTTQLPTP------------------------GPTP------SATTVP---PQGSPATSQPPN 785

  Fly   966 MPPQPQQFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTSA 1030
                  |.||.             :.|..|                         :|.|.|||
  Rat   786 ------QTQST-------------VAPAAH-------------------------TLIQQTPT-- 804

  Fly  1031 GPPSLQHGLHPGHQHSQLSVASSIPPSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPPS 1095
                    |||                                 |.|                ||
  Rat   805 --------LHP---------------------------------PRL----------------PS 812

  Fly  1096 MHPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPPRSMHDPQSS 1160
            .||    ||
  Rat   813 PHP----PL-------------------------------------------------------- 817

  Fly  1161 REPPTSQPSTTMAGSSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPMAIHPHLAHLPPG 1225
                  ||.|         .||.|.|...|   |.|.|.|.|||.|    |.:...|.|.|  ||
  Rat   818 ------QPMT---------APPSQNSAQPH---PQPSLHGQGPPGP----HSLQTGPLLQH--PG 858

  Fly  1226 HPAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPHSHASSAPL 1290
            .|.                               |.||           ||.
  Rat   859 PPQ-------------------------------PFGL-----------TPQ------------- 868

  Fly  1291 TAHSVASMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSSAAAAAAAAA 1355
                                              ||.|.||.||                :.|||
  Rat   869 ----------------------------------SSQGQGPLGP----------------SPAAA 883

  Fly  1356 HRAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQSPHMTP-PPV 1419
            |    |.|::...:.||.|.|                                ||.|...| ||
  Rat   884 H----PHSTIQLPASQSALQP--------------------------------QQPPREQPLPP- 911

  Fly  1420 SNASLMASPLSKMYAPQPGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPGGGIPQIGVHP 1484
                   :||:.                ||::|   ||....||:|           .||...||
  Rat   912 -------APLAM----------------PHIKP---PPTTPIPQLP-----------APQAHKHP 939

  Fly  1485 GQSPYPHPLLHPSVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGP 1549
                 || |..||        ||:           ..|.:.|||   .|.|.:.::.||.....|
  Rat   940 -----PH-LSGPS--------PFS-----------MNANLPPPP---ALKPLSSLSTHHPPSAHP 976

  Fly  1550 PPQQMRQDEQNAAAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGM--PPNKPPTPKTPQGPGG 1612
            ||.|:....|...::.||.....|.|:....||      .....||:  .|::.|.|:.|..|||
  Rat   977 PPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAA------SHPTTGGLHQVPSQSPFPQHPFVPGG 1035

  Fly  1613 GMPPGMGGPGTPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDALRAHAHSAN 1677
              ||    |.||...||.:.|       |.||...|       ||    |.|          :|.
  Rat  1036 --PP----PITPPSCPPTSTP-------PAGPSSSS-------QP----PCS----------AAV 1066

  Fly  1678 SAGMGGGHHPTEPLP-IDIEPD-----PEPEIPSPTHNIPRGPSPEAKPDDTECHRSQSAIFVRH 1736
            |:|......|:.||| :.|:.:     .|||.|.|.   ||.||||....||..|.||||.|.:|
  Rat  1067 SSGGNVPGAPSCPLPAVQIKEEALDEAEEPESPPPP---PRSPSPEPTVVDTPSHASQSARFYKH 1128

  Fly  1737 IDRGDYNSCTRTDLIFKPVADSKLARKREERDRKL---------AEKERERRQQQQQQQQQQQQQ 1792
            :||| ||||.||||.|.|:|.||||:||||...|.         .|:|||:.:::::::::::::
  Rat  1129 LDRG-YNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 1192

  Fly  1793 QAAAAQQAAQQAKMKAELK------------------------PPY--ADTPALRQLSEYARPHV 1831
            :|..|.|.|..:..:..|.                        |||  .||||||.|||||||||
  Rat  1193 EAERAAQKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHV 1257

  Fly  1832 ------------AFSPVEQMVPYHHP----MGPMYRERELEEIKNAQAAAASQS----------- 1869
                        ..:|.:.::.||.|    :.|..|||||.|.:..:.....:.
  Rat  1258 MSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEV 1322

  Fly  1870 ---RLDP-----HWMEYYRR----------GIHPSQFPLYANPAISQMERERLGIPPPHHVGLDP 1916
               .|||     :.||::.|          |.||  |..: :|.::.:|||||.:..|.   |.|
  Rat  1323 KPPELDPLHPATNPMEHFARHSALTIPPAAGPHP--FASF-HPGLNPLERERLALAGPQ---LRP 1381

  Fly  1917 --------------GEHMIRLTRE---------------YHAHSHTHLHL------------PLH 1940
                          .|.|..||.:               .|:|.|:||||            |:|
  Rat  1382 EMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVH 1446

  Fly  1941 PQPQPPEAGFQLPPNVGQYP-----RPNMLIPREPHSDVLLR----------------------- 1977
            |...|..||    |::.::|     .||.|:.:.||...:||
  Rat  1447 PLVDPLTAG----PHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFAEPVLRLAGTPYPRDLPGA 1507

  Fly  1978 ----MSYADQLQ--YLQAAEFQRQSLHDQY 2001
                ||.|.|||  :.|:||.||.::..|:
  Rat  1508 IPPPMSAAHQLQAMHAQSAELQRLAMEQQW 1537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	31/58 (53%)
		SANT	125..172	CDD:197842	33/46 (72%)
		SANT_MTA3_like	126..171	CDD:212559	31/44 (70%)
		Sec_Non_Glob	344..>440	CDD:275213	22/95 (23%)
Rere	XP_008762420.1	BAH_MTA	101..306	CDD:240060	19/30 (63%)
		ELM2	285..335	CDD:279754	31/58 (53%)
		SANT_MTA3_like	394..439	CDD:212559	31/44 (70%)
		SANT	395..440	CDD:197842	32/44 (73%)
		ZnF_GATA	502..551	CDD:214648	13/99 (13%)
		ZnF_GATA	505..559	CDD:238123	14/70 (20%)
		Atrophin-1	567..1566	CDD:281189	366/1799 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341454
Domainoid	1	1.000	187	1.000	Domainoid score	I3241
eggNOG	1	0.900	-	-		E1_KOG2133
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003731
OrthoInspector	1	1.000	-	-		otm45442
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13859
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2587
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930