DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gug and mta2

DIOPT Version :9

Sequence 1:	NP_001261581.1	Gene:	Gug / 46156	FlyBaseID:	FBgn0010825	Length:	2007	Species:	Drosophila melanogaster
Sequence 2:	XP_002941508.2	Gene:	mta2 / 100126057	XenbaseID:	XB-GENE-947630	Length:	672	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	143/718 - (19%)
Similarity:	218/718 - (30%)	Gaps:	260/718 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDER---ELEESRWSP-GVVADGDLLMFLRAA 66
            |||||||..:|     |::||.      ..:.|.|.|   ::|...|.| ..:.|..:..||..|
Frog   144 QGEIRVGSKYQ-----AEIPDQ------LAEGEPDNRNQQKMEIKVWDPENPLTDRQIDQFLVVA 197

  Fly    67 RSMAAFQGMCD-------GGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVK--CPV-SK 121
            |::..|....|       ..|.....|||||.|..:|:|.|..:|||..:|:..||.  .|| .:
Frog   198 RAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQRNGYDLARAMSTLVPQGGPVLCR 262

  Fly   122 GIDKKWTEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQ 186
            ...::|:..|...|.:.|.::||:|..|.:|.||.|....:|:|||:||.|        .|..:|
Frog   263 DEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTT--------DRYIQQ 319

  Fly   187 SALRRNRVTRANNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDA 251
            ..|:                                ||.|.|:......|..:|
Frog   320 KRLK--------------------------------AAEADSKLKQVYIPTYTK----------- 341

  Fly   252 SECDSDSSLTHKRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSS 316
                                      .|.|...|.|:....||.|....::.          .|.
Frog   342 --------------------------PNPNQIISVGSKPGLNGAGFQKGLTC----------ESC 370

  Fly   317 SKDQSANAVANGKRPKRGSETPDVS--------------GGASVDSPKTPTKAVAESSANKRKGG 367
            ....||...|.|        .|::.              ||.     ||||:  .|.:|  |..|
Frog   371 HTTVSAQWYAWG--------PPNMQCRLCASCWIYWKKYGGL-----KTPTQ--LEGAA--RNIG 418

  Fly   368 KQDTPNKKKRTEQESNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQ 432
            :..:.....|.|.:|..|.....|..|            :.:.:|...:|     .||..|...:
Frog   419 EPHSRGHLSRPEAQSLSPYTTSANRAK------------LLAKNRQTFLL-----QTTKLTRIAR 466

  Fly   433 QSTKD--SKETVSCKEEREMVTNDLEA-------KAEEKAIKAEALAEDSKDSAIKNMDEETNIQ 488
            :..:|  .....:.:....:.:|.::|       ||.:..:|...|...|..:.:|    |...|
Frog   467 RMCRDILQPRRAARRPYAPINSNSIKAECSVRLPKASKTPLKILPLVRPSLAAIVK----ELAAQ 527

  Fly   489 APSSADTSLVDGPNPNALPSPVAAPITMK-------VPTIATVEALNASVDRKEAIEKMES---- 542
            ||....|           |.....||...       :..:....|.:|.|.....|....|
Frog   528 APLKPKT-----------PRGTKTPINRNQLSQSRGLSVLPPKRAFDAQVSGVGVIPPFSSNGRS 581

  Fly   543 ------CDSDPEMLKKLATIKQEVSP-------------QQQQHMQQQSQQQMQQQLAPVGIPQP 588
                  ..|.|.:.::...:....:|             :...||:.:...:...|...:.:|.|
Frog   582 FSSGVRSSSQPGVKRQKLNLADAPNPVVFVATKDTRSLRKNLTHMEMRRAARRPSQPVKLKVPLP 646

  Fly   589 PSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHSAGGLPPSGPCAPPSAL 653
            |                            .|.::                  |||..|..|.|..
Frog   647 P----------------------------RPTNI------------------LPPLNPAHPASTS 665

  Fly   654 HPL 656
            .|:
Frog   666 EPI 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gug	NP_001261581.1	ELM2	9..68	CDD:279754	18/62 (29%)
		SANT	125..172	CDD:197842	18/46 (39%)
		SANT_MTA3_like	126..171	CDD:212559	17/44 (39%)
		Sec_Non_Glob	344..>440	CDD:275213	20/97 (21%)
mta2	XP_002941508.2	BAH_MTA	3..168	CDD:240060	12/34 (35%)
		ELM2	147..198	CDD:366648	17/61 (28%)
		SANT_MTA3_like	267..312	CDD:212559	17/44 (39%)
		ZnF_GATA	363..413	CDD:214648	13/74 (18%)
		MTA_R1	449..524	CDD:375062	14/83 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D802091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920