DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)02640 and HEM3

DIOPT Version :9

Sequence 1:	NP_612103.1	Gene:	l(3)02640 / 46140	FlyBaseID:	FBgn0010786	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_010076.1	Gene:	HEM3 / 851322	SGDID:	S000002364	Length:	327	Species:	Saccharomyces cerevisiae

Alignment Length:	299	Identity:	114/299 - (38%)
Similarity:	176/299 - (58%)	Gaps:	11/299 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVIRVGSRKSELALIQTKHVIGRLQKLYPKQKFEIHTMSTFGDRVLNVSLPKIGEKSLFTRDLED 70
            :.:.:|.|||:||:||:.||:..:::.||....::.|:.|.||::....|...|.|:|:|::|||
Yeast     4 ETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELED 68

  Fly    71 ALRNGG----VDFVVHSLKDLPTALPTGMAIGAVLEREDARDALVLRENFKGHTIASLPKGSVIG 131
            .|.:..    :|.:||||||:||.||.|..:|.:.:|.|..|.||:.......::..||.|.::|
Yeast    69 HLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVG 133

  Fly   132 TSSLRRTAQIRRMYPHLTVCDIRGNLNTRLAKLDAADSKFSGIILAQAGLVRMGWMSRISQVLEP 196
            |||:||:||::|.||||....:|||:.|||.|||...|.:..||||.|||:|||..:||:|....
Yeast   134 TSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLMRMGLENRITQRFHS 198

  Fly   197 TDLLYAVGQGALAVECRANDDQVLAMLQKLMCLNTTCRILAERSFLKTLGGGCSAPVAVWSNLKG 261
            ..:.:|||||||.:|.|..|.:::.:|.::..||.|...|:||:.::||.||||.|:.|.|..
Yeast   199 DTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKY-- 261

  Fly   262 EPLNGNSQEVGLSLTGAVWSLDGAIEIRNHLACALNEQK 300
                 |.:...|.|...|..::|...:.:.:...:...|
Yeast   262 -----NEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVK 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)02640	NP_612103.1	hemC	6..289	CDD:234612	113/286 (40%)
l(3)02640	NP_612103.1	PBP2_HuPBGD_like	7..296	CDD:270363	113/292 (39%)
HEM3	NP_010076.1	PBP2_HuPBGD_like	5..291	CDD:270363	113/292 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345158
Domainoid	1	1.000	177	1.000	Domainoid score	I725
eggNOG	1	0.900	-	-		E1_COG0181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H158
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004130
OrthoInspector	1	1.000	-	-		oto99617
orthoMCL	1	0.900	-	-		OOG6_101048
Panther	1	1.100	-	-	LDO	PTHR11557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R556
SonicParanoid	1	1.000	-	-		X2873
TreeFam	1	0.960	-	-
	12	11.730