DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)02640 and Hmbs

DIOPT Version :9

Sequence 1:	NP_612103.1	Gene:	l(3)02640 / 46140	FlyBaseID:	FBgn0010786	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_038936830.1	Gene:	Hmbs / 25709	RGDID:	2801	Length:	420	Species:	Rattus norvegicus

Alignment Length:	354	Identity:	166/354 - (46%)
Similarity:	212/354 - (59%)	Gaps:	52/354 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVIRVGSRKSELALIQTKHVIGRLQKLYPKQKFEIHTMSTFGDRVLN---------------VSL 55
            :|||||:|||:||.|||..|:..|:.|||..:|||..|||.||::|:               |||
  Rat    50 RVIRVGTRKSQLARIQTDTVVAMLKTLYPGIQFEIIAMSTTGDKILDTALSKVMAVLIPACLVSL 114

  Fly    56 P-------------KIGEKSLFTRDLEDALRNGGVDFVVHSLKDLPTALPTGMAIGAVLEREDAR 107
            |             :||||||||::||:||....||.|||||||:||.||.|..|||:.:||:..
  Rat   115 PTYKGFTLRFFLPWQIGEKSLFTKELENALEKNEVDLVVHSLKDVPTILPPGFTIGAICKRENPC 179

  Fly   108 DALVLRENFKGHTIASLPKGSVIGTSSLRRTAQIRRMYPHLTVCDIRGNLNTRLAKLDAADSKFS 172
            ||:|....|.|.|:.:||:.|.:|||||||.||::|.:|||....|||||||||.|||.. .:||
  Rat   180 DAVVFHPKFIGKTLETLPEKSAVGTSSLRRVAQLQRKFPHLEFKSIRGNLNTRLRKLDEL-QEFS 243

  Fly   173 GIILAQAGLVRMGWMSRISQVLEPTDLLYAVGQGALAVECRANDDQVLAMLQKLMCLNTTCRILA 237
            .||||.|||.||||.:|:.|:|.|.:.:|||||||||||.||.|..:|.::..|....|..|.:|
  Rat   244 AIILAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVGVLHDPETLLRCIA 308

  Fly   238 ERSFLKTLGGGCSAPVAVWSNLKGEPLNGNSQEVGLSLTGAVWSLDGAIEIRNHLACAL-----N 297
            ||:||:.|.||||.||||.:.:|    :|.     |.|||.||||||:..::..:...:     .
  Rat   309 ERAFLRHLEGGCSVPVAVHTVMK----DGQ-----LYLTGGVWSLDGSDSMQETMQATIQVPVQQ 364

  Fly   298 EQKLEGDQR---------KRGAQEATSQL 317
            |...|.|.:         .||||.|...|
  Rat   365 EDGPEDDPQLVGITARNIPRGAQLAAENL 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)02640	NP_612103.1	hemC	6..289	CDD:234612	157/310 (51%)
l(3)02640	NP_612103.1	PBP2_HuPBGD_like	7..296	CDD:270363	157/316 (50%)
Hmbs	XP_038936830.1	PBP2_HuPBGD_like	51..358	CDD:270363	157/316 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348339
Domainoid	1	1.000	239	1.000	Domainoid score	I2210
eggNOG	1	0.900	-	-		E1_COG0181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H158
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1189095at2759
OrthoFinder	1	1.000	-	-		FOG0004130
OrthoInspector	1	1.000	-	-		oto97090
orthoMCL	1	0.900	-	-		OOG6_101048
Panther	1	1.100	-	-	LDO	PTHR11557
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2873
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.710