Protein Alignment Nup214 and NUP159

DIOPT Version :9

• Sequence 1: NP_652039.2
• Gene: Nup214 / 46091
• FlyBaseID: FBgn0010660
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_012151.1
• Gene: NUP159 / 854691
• SGDID: S000001377
• Length: 1460
• Species: Saccharomyces cerevisiae
• Alignment Length: 1264
• Identity: 249/1264 - (19%)
• Similarity: 426/1264 - (33%)
• Gaps: 444/1264 - (35%)

  Fly     9 EDTQDFQFKLHHKIVAFKKCGE--PRSNVNLLAVSSSRGLLFAGSPTQP---ELKVIIVKDLVNA 68
            |.::||.||...:........|  |.:::..|.:|:|:.|..|.|.::.   ||:  :::|.:.:
Yeast    11 ETSEDFGFKFLGQKQILPSFNEKLPFASLQNLDISNSKSLFVAASGSKAVVGELQ--LLRDHITS 73

  Fly    69 KSTAQQPQARLVPL-----PSIPNYIACSSDGNLLAVNHTQNGTSLLSIYAVLSF--MTPDVRPV 126
            .||         ||     ..||:.|.....|:.:.|: |:|....|.:..:..|  :|...:||
Yeast    74 DST---------PLTFKWEKEIPDVIFVCFHGDQVLVS-TRNALYSLDLEELSEFRTVTSFEKPV 128

  Fly   127 YNIRLAAEDHVHGVQLLWNPV------------------------LPNS-LAVVLSNGALAMYAL 166
            :.::     :|:...::.|.|                        :.|| |||:|.:.:...:|.
Yeast   129 FQLK-----NVNNTLVILNSVNDLSALDLRTKSTKQLAQNVTSFDVTNSQLAVLLKDRSFQSFAW 188

  Fly   167 KEGGNFEMHSLDKNQQVKCGCWSPKGKQIVLGFPGG----TVKQFKPDLTLAKTLLCPPNIHDAP 227
            :.|   ||.                 ||.....|..    .|:::.|   |:.|:|       :|
Yeast   189 RNG---EME-----------------KQFEFSLPSELEELPVEEYSP---LSVTIL-------SP 223

  Fly   228 FDTIAIQWLSTFQFAVIFLQHGEDCS--PSLYILNAPKAGAPSYINYYDICYSMNGPRNHQFVFS 290
            .|.:|:       |..:..:..::.|  ..:||:.... |:.|:...:||    ..|      |.
Yeast   224 QDFLAV-------FGNVISETDDEVSYDQKMYIIKHID-GSASFQETFDI----TPP------FG 270

  Fly   291 HVPQWNLLLVVSANGV-----EVGIMRSTEAGDTPAWQQLTLL----DEARIEMPLSEDKD-ETF 345
            .:.::..:..|:.:|:     .|.::.|:.:.:...|....::    |..|..:|:||:.| :|.
Yeast   271 QIVRFPYMYKVTLSGLIEPDANVNVLASSCSSEVSIWDSKQVIEPSQDSERAVLPISEETDKDTN 335

  Fly   346 PLGFAFDTSTTHQLTINE-----KKLQTMPMVHVLSSDGELLSFNFLNVL--------------- 390
            |:|.|.|..|:.  ||.|     ..::.:|:|::|:::|.|......:|.
Yeast   336 PIGVAVDVVTSG--TILEPCSGVDTIERLPLVYILNNEGSLQIVGLFHVAAIKSGHYSINLESLE 398

  Fly   391 -PTAVSVCSPPPPVADTSGQFKPLNMLLASEEEEQPAWAASPS------KAPAATPAASSDISFA 448
             ..::|..|...|:|....:.|..|...:....|.|..:|:.|      ..|||..:..|..|..
Yeast   399 HEKSLSPTSEKIPIAGQEQEEKKKNNESSKALSENPFTSANTSGFTFLKTQPAAANSLQSQSSST 463

  Fly   449 F-TPN-----------TVTST-------------PAPSKD-----------KQPSLFS------- 470
            | .|:           :|:||             ||.:|.           |:||...
Yeast   464 FGAPSFGSSAFKIDLPSVSSTSTGVASSEQDATDPASAKPVFGKPAFGAIAKEPSTSEYAFGKPS 528

  Fly   471 ------GFGAAAAKAPAPQLSFGTAPTSSPVSFGA-------PTTNAA--KPT--TP-FGGFGTQ 517
                  |.|.::.::||...:||.....:| |||:       |.:.:|  ||:  || ||...:.
Yeast   529 FGAPSFGSGKSSVESPASGSAFGKPSFGTP-SFGSGNSSVEPPASGSAFGKPSFGTPSFGSGNSS 592

  Fly   518 ATTTAMGSMFS--ASGANAFGGMALNKPAIASVTPRTAAPGSTVPATPASAPANKPLYTVPLTFT 580
            |...|.||.|.  :.|.:|||..:.|:....|:..: ||.||:     :.||||..|:....|.
Yeast   593 AEPPASGSAFGKPSFGTSAFGTASSNETNSGSIFGK-AAFGSS-----SFAPANNELFGSNFTI- 650

  Fly   581 PVDTKPATSAPPQIADESLKPDDTEPIIKDMIALQIEAFSKDIQKQKEQTKELLKGIAAPSALRA 645
               :||...:|.::       |.|.|            |.....:.::::|..:...:.|...:
Yeast   651 ---SKPTVDSPKEV-------DSTSP------------FPSSGDQSEDESKSDVDSSSTPFGTK- 692

  Fly   646 YAKRLDDLQELNEQAKDVEFELDVQGLRQGLNEAY-AIVAECRGKLEIYRKPEITRLMNSSSCDP 709
                    ...:.:.|...|:........|.::|. ::.::...|......|..::|.|.|.
Yeast   693 --------PNTSTKPKTNAFDFGSSSFGSGFSKALESVGSDTTFKFGTQASPFSSQLGNKSP--- 746

  Fly   710 SGRRMLARLQSYVAANEAQLRLAQQHVDLQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLT 774
                    ..|:.                     :|.....|.|:                   .
Yeast   747 --------FSSFT---------------------KDDTENGSLSK-------------------G 763

  Fly   775 SNQRIVQNNIKSKLKERGLLQAALLDQEKSRTRTNEAVDTLTDSILTMSLS------------QV 827
            |...|..:|                 :|......|.:.:.||||.:..:.|            :|
Yeast   764 STSEINDDN-----------------EEHESNGPNVSGNDLTDSTVEQTSSTRLPETPSDEDGEV 811

  Fly   828 VDSNA-----AKLTRERLQKIRNIVQLQKINVICPQRPDRVGLKSEVI-LETKRRAEQ------- 879
            |:..|     .||| |.::|..||              |..|||:.|. ...|.::|.
Yeast   812 VEEEAQKSPIGKLT-ETIKKSANI--------------DMAGLKNPVFGNHVKAKSESPFSAFAT 861

  Fly   880 --IKRAAAKPA------TANKYTQAAVAPPSPPDVAPTPAVAPMPQATVTVAPPLPKPMPSIPSV 936
              .|.::..||      |.||...:.|:|....|...|....|:...:|        ..|.:|:.
Yeast   862 NITKPSSTTPAFSFGNSTMNKSNTSTVSPMEEADTKETSEKGPITLKSV--------ENPFLPAK 918

  Fly   937 VEKPGVPTHPTTPVATPFSFSQSIPFVKTSTVTPTTNTVTPGEAAK------PGLSIFGGSTISS 995
            .|:                                     .||::|      |......||.||
Yeast   919 EER-------------------------------------TGESSKKDHNDDPKDGYVSGSEIS- 945

  Fly   996 FSFGGGAAKSALSFGTGSPAVAAPTPKPNPLSAVEKPTPEPTKPKEQKAA------ESKEFKAVQ 1054
                  ...|..:|.|   ......||...::..||   ..|.||..:.|      :|||.....
Yeast   946 ------VRTSESAFDT---TANEEIPKSQDVNNHEK---SETDPKYSQHAVVDHDNKSKEMNETS 998

  Fly  1055 PETEESKVPQKP--------KAETENKSF 1075
            ...|.|..|...        |.:.|.::|
Yeast   999 KNNERSGQPNHGVQGDGIALKKDNEKENF 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201	49/240 (20%)
		WD40 repeat	38..86	CDD:293791	13/55 (24%)
		WD40 repeat	90..131	CDD:293791	9/42 (21%)
		WD40 repeat	139..173	CDD:293791	10/58 (17%)
NUP159	NP_012151.1	NUP214	24..380	CDD:407023	86/422 (20%)
		COG5651	142..673	CDD:227938	131/610 (21%)
		PTZ00395	<558..>874	CDD:185594	85/437 (19%)
		PRK08581	751..>1006	CDD:236304	69/384 (18%)
		MDN1	<892..1163	CDD:227596	35/194 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3630
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R851
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930