Protein Alignment Nup214 and NUP1

DIOPT Version :9

• Sequence 1: NP_652039.2
• Gene: Nup214 / 46091
• FlyBaseID: FBgn0010660
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_014741.1
• Gene: NUP1 / 854265
• SGDID: S000005624
• Length: 1076
• Species: Saccharomyces cerevisiae
• Alignment Length: 1152
• Identity: 250/1152 - (21%)
• Similarity: 381/1152 - (33%)
• Gaps: 367/1152 - (31%)

  Fly   775 SNQRIVQNNIK--SKLKERGLLQAALLDQEKSRTRTNEAVDTLTDS-----ILTMS--------L 824
            |::::..:|:.  :.|:|..:.....:::.|..:.|::..|:||.:     |:...        |
Yeast    36 SSKKVFSSNLSYANHLEESDVEDTLHVNKRKRVSGTSQHSDSLTQNNNNAPIIIYGTENTERPPL 100

  Fly   825 SQVVDSNAAKLTRERLQKIRNIVQLQKINVICPQRPDRVGLKSEVILETKRRAEQIKRAAAKPAT 889
            ..::.....:|.||: |::||:.:|..|     |..:...:.|.|||.::.::::
Yeast   101 LPILPIQRLRLLREK-QRVRNMRELGLI-----QSTEFPSITSSVILGSQSKSDE---------- 149

  Fly   890 ANKYTQAAVAPPSPPDVAPTPAVAPMPQATVTVAPPLPKPMPSIPSVVEKPGVPTHPTTPVATPF 954
            ...|...:..|....:.:.|..:|........|.      :|.:.|:..:.......:....|.:
Yeast   150 GGSYLCTSSTPSPIKNGSCTRQLAGKSGEDTNVG------LPILKSLKNRSNRKRFHSQSKGTVW 208

  Fly   955 SFSQSIPFVKTSTVTPTTNTVTPGEAAKPGLSIFGGSTISSFSFGGGAAKSALSFG---TGSPAV 1016
            |.:......:...:....|....|.|        ||...:|.:...  .||::|.|   || |.:
Yeast   209 SANFEYDLSEYDAIQKKDNKDKEGNA--------GGDQKTSENRNN--IKSSISNGNLATG-PNL 262

  Fly  1017 AA--------------PTPKPN-----PLSAVEKPTP---------------------EPTKPKE 1041
            .:              ..|:.|     |.|.|.|..|                     ||.|.||
Yeast   263 TSEIEDLRADINSNRLSNPQKNLLLKGPASTVAKTAPIQESFVPNSERSGTPTLKKNIEPKKDKE 327

  Fly  1042 QKAAESKEFKAVQPETEESKVPQK---PK------------------------AETENKSFGFGG 1079
            .....:..|..:    ::::.|.|   ||                        ||....||.|..
Yeast   328 SIVLPTVGFDFI----KDNETPSKKTSPKATSSAGAVFKSSVEMGKTDKSTKTAEAPTLSFNFSQ 388

  Fly  1080 FTGTGGTVGNT--SSSPFSFGGLGSSLGFGGTAAAVP-----KSEPSSTATTSVATSASTAPFGI 1137
            .......|.||  |::.|:|||...::    |:|:.|     .||.|...|.|.|...||||  |
Yeast   389 KANKTKAVDNTVPSTTLFNFGGKSDTV----TSASQPFKFGKTSEKSENHTESDAPPKSTAP--I 447

  Fly  1138 FS----------------------AALAKPSNSEPI-----------TTVTSNTTTITSKPTNVI 1169
            ||                      ..:::.:|::|:           |....:....:.||:.|.
Yeast   448 FSFGKQEENGDEGDDENEPKRKRRLPVSEDTNTKPLFDFGKTGDQKETKKGESEKDASGKPSFVF 512

  Fly  1170 ASSS--------VTDAPSVTTTNAVTSSTDPIGGLFSSVTICKPNTPADT-TKPANIFGGGLSAG 1225
            .:|.        .|.......|:.:.||        :..|..|..|..:| |||:......:...
Yeast   513 GASDKQAEGTPLFTFGKKADVTSNIDSS--------AQFTFGKAATAKETHTKPSETPATIVKKP 569

  Fly  1226 SFSFGGTIDASKGLFGSTKPVATAPTSVTEANNKTDPIST-----------------TPSAISTT 1273
            :|:||.:...:|...||.||  |...|.:|...|:.|||.                 .|:...|.
Yeast   570 TFTFGQSTSENKISEGSAKP--TFSFSKSEEERKSSPISNEAAKPSFSFPGKPVDVQAPTDDKTL 632

  Fly  1274 TATTTVSSPAVVPAAVTAAVPATSSTTVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLA 1338
            ..|.:.:.||...::|.:.....|.|..:|.|:.|...|||..:.                   |
Yeast   633 KPTFSFTEPAQKDSSVVSEPKKPSFTFASSKTSQPKPLFSFGKSD-------------------A 678

  Fly  1339 AKSPTATSTGNNSSNSVFGGGFAVATSTAAPVASPFQSAAKSPVSSANIFGSIPKAETSVFGGAT 1403
            ||.|    .|:|:|.|.                      .|.|   ||.....|...:..|||:|
Yeast   679 AKEP----PGSNTSFSF----------------------TKPP---ANETDKRPTPPSFTFGGST 714

  Fly  1404 TAPSNTTAAATPDAPPAGLFASAAISNPS-PFGSP-----TTRAPASGGNIFGQAVKPSVFGQPA 1462
            |  :|||..:|               .|| .||:|     |....|:...........:.|....
Yeast   715 T--NNTTTTST---------------KPSFSFGAPESMKSTASTAAANTEKLSNGFSFTKFNHNK 762

  Fly  1463 QAGDSGGSIFGGGSASTPF---------------GSSSIFGGGNTQGAVGAPAAGSTSI-FGQKV 1511
            :..:|..|.|.|.::|||.               .|:..||..||.|.  ..:|.|||. |....
Yeast   763 EKSNSPTSFFDGSASSTPIPVLGKPTDATGNTTSKSAFSFGTANTNGT--NASANSTSFSFNAPA 825

  Fly  1512 FGQ-SSAAAPAAGGNIFSN-PVGSPQASPFGG---GGNSIFGSPATAPPASGG----SIFG-GGS 1566
            .|. ::..:..:|.||... .||.|..|...|   |..|.||..::...|:|.    |.|. |.:
Yeast   826 TGNGTTTTSNTSGTNIAGTFNVGKPDQSIASGNTNGAGSAFGFSSSGTAATGAASNQSSFNFGNN 890

  Fly  1567 SSGGFGSFTQTT-----------------------PAQGGFGGGFGQGGGGSV--------AQTG 1600
            .:||...||..|                       |:...|.|.....|||||        |.|.
Yeast   891 GAGGLNPFTSATSSTNANAGLFNKPPSTNAQNVNVPSAFNFTGNNSTPGGGSVFNMNGNTNANTV 955

  Fly  1601 F-GSPQAPQQQTT----TPGGFGAKPV----FGG---------------SPAFGASPTFGGGATF 1641
            | ||...|.|..|    |...|....|    |.|               |..|||:...|..:..
Yeast   956 FAGSNNQPHQSQTPSFNTNSSFTPSTVPNINFSGLNGGITNTATNALRPSDIFGANAASGSNSNV 1020

  Fly  1642 GSPKG-FGGFGGASPVASPPPFGAAAKPAQGNIFETLGGQESGLSFG 1687
            .:|.. |||.||....:...|..|   |.|..:     |..:|:|.|
Yeast  1021 TNPSSIFGGAGGVPTTSFGQPQSA---PNQMGM-----GTNNGMSMG 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201
		WD40 repeat	38..86	CDD:293791
		WD40 repeat	90..131	CDD:293791
		WD40 repeat	139..173	CDD:293791
NUP1	NP_014741.1	PTZ00482	302..>490	CDD:240433	41/197 (21%)
		PTZ00108	<458..690	CDD:240271	54/264 (20%)
		COG5651	<737..1053	CDD:227938	81/325 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23193
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100