back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup214 and NUP214

DIOPT Version :9

Sequence 1:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_005076.3	Gene:	NUP214 / 8021	HGNCID:	8064	Length:	2090	Species:	Homo sapiens

Alignment Length:	2179	Identity:	561/2179 - (25%)
Similarity:	844/2179 - (38%)	Gaps:	588/2179 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DTQDFQFKLHHKIVAFKKCGE-PRSNVNLLAVSSSRGLLFAGSPTQPELKVIIVKDLVNAKSTAQ 73
            :.:||||:...|:..|....| |:...:|||||:..||:|||..:  .|::...|:|:.......
Human    13 EMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGAS--GLQIFPTKNLLIQNKPGD 75

  Fly    74 QP-------QARLVPLPSIPNYIACSSDG-NLLAVNHTQNGTSLLSIYAVLSFMT---PDVRPVY 127
            .|       |..|||:....:::|.|.|. .|.|...:....|:::.:.|.:|..   ...||..
Human    76 DPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFA 140

  Fly   128 NIRLAAEDHVHGVQLLWNPVLPNSLAVVLSNGALAMYALKEGGNFEMHSLDKNQQVKCGCWSPKG 192
            ..:|..:.....:.:.|||.:|:.:||.|::|::|:..:.|.... ..:|.....|...||||||
Human   141 YHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKV-CATLPSTVAVTSVCWSPKG 204

  Fly   193 KQIVLGFPGGTVKQFKPDLTLAKTLLCPPNIH-DAPFDTIAIQWLSTFQFAVIFLQHGE--DCSP 254
            ||:.:|...|||.|:.|.|...|.:.|||... |.|...:.:.|:.|:.||:::.....  :.||
Human   205 KQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSP 269

  Fly   255 SLYILNAPKAGAPS---YINYYDICYSMNGPRNHQFVFSHVPQWNLLLVVSANGVEVGIMRSTEA 316
            .:.:...||.....   ::|:.:.||.....|.|.:..|::.:|:|:|..||...||.|:  ...
Human   270 DVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAASTEVSIL--ARQ 332

  Fly   317 GDTPAWQQLTLLDEARIEMPLSEDKDETFPLGFAFDTSTTHQLTI-NEKKLQTMPMVHVLSSDGE 380
            .|...|:...|.|.:|.|:|:::..|::.|:|...|.:...::|| :||.|...|::.:||:||.
Human   333 SDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGV 397

  Fly   381 LLSFNFLNVLPTAVSVCSPP----------------PPVADTSGQFKPLNMLLASEEEEQPAWAA 429
            |..|..:|..|...|:...|                .|...||.|        |.::.:..| ||
Human   398 LCPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQ--------APQKLDASA-AA 453

  Fly   430 SPSKAPAATPAA-----------SSDISFAFTPNTVTSTPAPSKDKQPSLFSGFGAA-AAKAPAP 482
            :|:..|.::|||           .:...|:|..:::.|: |....:.||..||..:: ||..|.|
Human   454 APASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSS-ATVTGEPPSYSSGSDSSKAAPGPGP 517

  Fly   483 ---------QLSFGTAPTSSPV-------SFGA----PTTN------------AAKPTTP----- 510
                     :.|....|.:|||       |||:    ||..            |.||:.|
Human   518 STFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSA 582

  Fly   511 -----FGGFGTQATTTAMGSMFSASGANAFGGMALNKPA----IASVTPRTAAPGSTVP------ 560
                 ...|...||:|.:.|..||...:.|.  :.:|||    ::..|| .:||.|:||
Human   583 VKVNLSEKFTAAATSTPVSSSQSAPPMSPFS--SASKPAASGPLSHPTP-LSAPPSSVPLKSSVL 644

  Fly   561 -------ATPASAPANKPLYTVPLTFTPVDTKP----ATSAPPQIAD-ESLKPDDTEPIIKDMIA 613
                   |..:|:|....:...| ..||...||    |.|..|.:|: :..:..|::|::.. |.
Human   645 PSPSGRSAQGSSSPVPSMVQKSP-RITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAG-IG 707

  Fly   614 LQIEAFSKDIQKQKEQTKELLKGIAAPSALRAYAKRLDDLQELNEQAKDVEFEL--DVQGLRQGL 676
            .:|..|.|::::.|.:|.:....:.....::......|||.....:.|:....|  |:..|:..|
Human   708 EEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL 772

  Fly   677 NEAYAIVAECRGKLEIYRKPEITRLMNSSSCDPSGRRML---ARLQSYVAANEAQLRLAQQHV-- 736
            .|.:|.|.|.|.:.|..|......|:.....||.....|   .||..||       :.|.|.|
Human   773 LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYV-------KFAVQDVND 830

  Fly   737 --DLQWEQFQDVVRRNSKSRMHM--PCLEGIYQRLTRLQNLTSNQRIVQNNIKSKLKERGLLQAA 797
              ||:|:|..:    ..|.:.|:  |..|.::..|...:.:.:.||...|::...|::..|.:..
Human   831 VLDLEWDQHLE----QKKKQRHLLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQT 891

  Fly   798 LLDQEKSRTRTNEAV---DTLTDSILTMSLSQVVDSNA-------AKLTRERLQKIRNIVQLQK- 851
            .|....|...:..::   |:..:|:....|...::|:.       |||:..:..::||.:..:|
Human   892 SLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKT 956

  Fly   852 --INVICPQRPDRVGLKSEVILE-------TKRRAEQIKRAAAKPATANKYTQAAVAPPSPPDVA 907
              :....|....|....|:...|       |...::.::...|:  |:.|..:|.|..|....|.
Human   957 PPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDAR--TSCKDDEAVVQAPRHAPVV 1019

  Fly   908 PTPAVAP----------------------------------MPQ-------ATVTVAPPLPKP-- 929
            .||::.|                                  :||       ||.||....|.|
Human  1020 RTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSH 1084

  Fly   930 ----------------------------------MPSIPSVVEKPGVPTHPTT------------ 948
                                              :|.:.:|.|....|..|:|
Human  1085 PISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAK 1149

  Fly   949 ---PVATPFSFSQS-----IPFVKTSTVTPTTNTVTPGEAAKPGLSIFGGSTISSFSFGGGAAKS 1005
               ||.||.:.:|:     |..:|.|..||.:..::.|:.|.....|  .:.::|.....|....
Human  1150 TPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKI--ETAVTSTPSASGQFSK 1212

  Fly  1006 ALSF---GTG-SPAVAAPTPKPNPLSAVEKPTPEPTKPKEQKAAESK------EFKAVQPETE-- 1058
            ..||   ||| :..:..|||..| .:|.:..||. ||...|..|.|.      .::|: ||:.
Human  1213 PFSFSPSGTGFNFGIITPTPSSN-FTAAQGATPS-TKESSQPDAFSSGGGSKPSYEAI-PESSPP 1274

  Fly  1059 ------ESKVPQKPKAETENKSFGFGGFTGTGGTVGNTSSS-----PFSFGGL-------GSSLG 1105
                  .:..|.:|.|.:...       ....||..:|:||     |...|.|       |.:||
Human  1275 SGITSASNTTPGEPAASSSRP-------VAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLG 1332

  Fly  1106 -FGGTA------AAVPKSEPSSTATTSV-ATSASTAPFGI-FSAALAKPSNSEPITTVTSNTTTI 1161
             |.|..      :..|.::.|||:.||. .|..|..|.|. |:|......::||..|.::.||::
Human  1333 SFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSV 1397

  Fly  1162 TSKPTNVIASSSVTDAPSVTTTNAVTSSTDPIGGLFSSVTICKPNTPADTTKPANIFGGGLSAG- 1225
                           ||...|:   ||||...|.|        |.|.|.::...:..|..||||
Human  1398 ---------------APPAATS---TSSTAVFGSL--------PVTSAGSSGVISFGGTSLSAGK 1436

  Fly  1226 -SFSFG-----GTIDASKG----------------LFGSTKPVATAPT-------SVTEANN--- 1258
             |||||     .|:..|..                .|||....||.|:       |..||.:
Human  1437 TSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSAL 1501

  Fly  1259 ------------------------------------KTDPISTTPSAISTTTATTTVS------- 1280
                                                |.:|:...|:..::.||.::.|
Human  1502 PEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAE 1566

  Fly  1281 -SPAV--VPAAVTAAVPATSSTTVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSP 1342
             :||.  ||.|.|.|||..||.:|...|||..:|.|        |||..|..|  :|.|:|:.:.
Human  1567 ATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAIS--------SAGPVAVET--SSTPIASSTT 1621

  Fly  1343 TATSTGNNSSNSVFG----GGFAVATSTAAPVASPF----QSAAKSPVSSANIFGSIPKAETSVF 1399
            :..:.|.::..:.||    |....|...||..:|.|    .:.|.:| |:..:||.:..:.....
Human  1622 SIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAP-SATPVFGQVAASTAPSL 1685

  Fly  1400 GGATTAPSNTTAAATPDAPPAGLFASAAISNPSP--FGSPTTRAPASGGNIFGQAVKPS------ 1456
            .|..|..:.:||||||....:| |:|.|....:|  ||. ||...||   :|||:...:
Human  1686 FGQQTGSTASTAAATPQVSSSG-FSSPAFGTTAPGVFGQ-TTFGQAS---VFGQSASSAASVFSF 1745

  Fly  1457 ---------VFGQPAQA--GDSGGSIFG-----GGSASTPFGSSSIFGGGNTQGAVGAPAAGSTS 1505
                     .|||||.:  ..:.||:||     ..|:|..||.||...||...|...|||.|.:.
Human  1746 SQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSP 1810

  Fly  1506 IFGQ--KVFGQSSAAAPAAGGNIFSNPVGSPQASPFGGGG-NSIFGSPATA--------PPASGG 1559
            .|||  .|||.:|||...|..:.||    ..|||.||... .|:||..|:.        ..:|.|
Human  1811 GFGQGGSVFGGTSAATTTAATSGFS----FCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSG 1871

  Fly  1560 SIFGGG---------------------------SSSGGFGSFTQTTPAQGGFG-------GGFG- 1589
            |:||.|                           |:|||||| |.|:.....||       |||.
Human  1872 SVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGS-TATSNTSNLFGNSGAKTFGGFAS 1935

  Fly  1590 ------------QGGGGSVAQTGFG--SPQAPQQQTTTPGGFGAKPVFGGSPAFGASPTFGGGAT 1640
                        ..||||||..|||  ||       ...|||||.||||..|.||.||.|||...
Human  1936 SSFGEQKPTGTFSSGGGSVASQGFGFSSP-------NKTGGFGAAPVFGSPPTFGGSPGFGGVPA 1993

  Fly  1641 FGSPKGF---------------------GGFG----------GASPVASPPPFGAAAKPAQGNIF 1674
            |||...|                     ||||          |.....:.|.||:.::...|
Human  1994 FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSG--- 2055

  Fly  1675 ETLGGQESGLS-FGNLA---QTGNSNAQKPAFGG 1704
              .|.|.||.| ||:..   ..|::|:....|||
Human  2056 --FGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGG 2087

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.