DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup214 and nup98

DIOPT Version :9

Sequence 1:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_956979.2	Gene:	nup98 / 777756	ZFINID:	ZDB-GENE-040426-1180	Length:	1814	Species:	Danio rerio

Alignment Length:	677	Identity:	177/677 - (26%)
Similarity:	249/677 - (36%)	Gaps:	226/677 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1072 NKSFG--FGGFTGTGGTVGNTSSSPFSFGGLGSSLGFGGTAAAVPKSEPSSTATTSVATSASTAP 1134
            |||||  |||  ||||.  .|||   :||...|  |||.|        |....:::..|:.:|.
Zfish     3 NKSFGAPFGG--GTGGF--GTSS---TFGQPNS--GFGAT--------PGGFGSSAFGTTNNTG- 49

  Fly  1135 FGIFSAALAKPSNSEPITTVTSNTTTITSKPTNVIASSSVTDAPSVTTTNAVTSSTDP-IGGLFS 1198
             |:|.....||......:|.:...|:.||......|:|.        |:|::..||:. .|||||
Zfish    50 -GLFGNTQNKPGGLFGSSTFSQPVTSSTSSGFGFGATSG--------TSNSLFGSTNTGGGGLFS 105

  Fly  1199 SVTICKPNTPADTTKPANI--FGGGLSAG---------SFSFGGTIDASKGLFGSTKPVATAPTS 1252
                 :.|......|||..  ||...|:|         |..||||   |..||||:...|..|.:
Zfish   106 -----QQNNAFGANKPAAFGNFGTSTSSGGLFGTTNTASNPFGGT---SGSLFGSSSFTAAPPGT 162

  Fly  1253 VTEANNKTDPISTTPSAISTTTAT-----TTV--------------------SSPAVVPAAV--- 1289
            ..:.|..|...:.....::|:..|     |.:                    ..|:.:|.|.
Zfish   163 TIKFNPPTGSDTMVKGGVTTSINTKHQCITAMKEYENKSLEELRLEDYQAGRKGPSNLPMAAGTG 227

  Fly  1290 ---TAAVPATSST-TVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSPTATSTGNN 1350
               .||.|||.|| |....::.|.:.|:|..                      .|:...||||
Zfish   228 GLFGAAAPATPSTGTGLFGSSAPNTGFNFGQ----------------------NKTTFGTSTG-- 268

  Fly  1351 SSNSVFGGGFAVATSTAAPVASPFQSAAKSPVSSANIFGSIPKAETSVFGGATTAPSNTTAAATP 1415
                      |..|:|.:..|.| |...:....::::|        ..||.|||..:||.:....
Zfish   269 ----------AFGTTTGSLFAQP-QQQQQQQQQNSSLF--------KPFGSATTTQNNTFSFGNT 314

  Fly  1416 DAPPA------GLFASAAISNPSPFGSPTTRAPASGGNIFGQAVKPSVFGQPAQAGDSGGSIFGG 1474
            .:..:      ||||:.|.|                                     ..|.:||.
Zfish   315 SSMVSSSWCTKGLFANTAAS-------------------------------------QAGGLFGN 342

  Fly  1475 GSASTPFG-SSSIFGGGNTQGAVGAPAAGSTSIFGQKV--FGQSSAAAPA--AGGNIFSNPVGSP 1534
            .:.||..| .:.|||..||    |....|:.::||.|.  ||.::.:||:  :|..:|:|   .|
Zfish   343 TNTSTATGFGTGIFGQTNT----GFGNVGTQNLFGNKPAGFGTTTTSAPSFGSGPGLFAN---KP 400

  Fly  1535 QASPFGGGGNSIFGSPATAPPASGGSIFGGGSSSGGFGSFTQTTPAQG-GFGGGFGQGGGGSVAQ 1598
            ..:.......|.||...|   .:||.:||..:::.|.|      |..| |||.|.|.|      |
Zfish   401 TLTLGTNTNTSTFGFSGT---GAGGGLFGNKTAATGLG------PVLGAGFGAGVGTG------Q 450

  Fly  1599 TG-FGSPQAPQQQTTTPGGFGAKPVFGGSPAFGASPTFGGGAT---FGSPKGFGGFGGASPVASP 1659
            |. ||:.|.......:.|.|||    ||         |..||:   ||:|:        .|:|..
Zfish   451 TSLFGNNQKLGSTLGSVGTFGA----GG---------FNTGASTLNFGAPQ--------QPIALT 494

  Fly  1660 PPFGAAAKPAQGNIFETLGGQESGLSF 1686
            .|...||:.|      .|..|.|.|::
Zfish   495 DPSAGAAQQA------VLQQQISALAY 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201
		WD40 repeat	38..86	CDD:293791
		WD40 repeat	90..131	CDD:293791
		WD40 repeat	139..173	CDD:293791
nup98	NP_956979.2	Nucleoporin_FG	39..133	CDD:290362	29/108 (27%)
		Nucleoporin_FG	217..357	CDD:290362	46/219 (21%)
		Nucleoporin_FG	324..>400	CDD:290362	29/119 (24%)
		Nucleoporin2	741..881	CDD:282016
		Nup96	1333..1626	CDD:288926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910