DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup214 and si:ch1073-263o8.2

DIOPT Version :9

Sequence 1:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_021324600.1	Gene:	si:ch1073-263o8.2 / 327151	ZFINID:	ZDB-GENE-030131-5362	Length:	1367	Species:	Danio rerio

Alignment Length:	768	Identity:	151/768 - (19%)
Similarity:	270/768 - (35%)	Gaps:	186/768 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1071 ENKSFGFGGFTGTGGTVGN-TSSSPFSF--GGLGSSLGFGGTAAAVPKSEPSST----ATTSVAT 1128
            |:.|..||.||.......| |....||.  ....:|..:|.  .::..:|.:||    .:...|.
Zfish   634 ESNSTLFGDFTLDDAEESNSTLYGNFSLDDDAESNSTLYGN--VSLDATESNSTLYGNVSLDAAA 696

  Fly  1129 SASTAPFGIFSAALAKPSNS-----------EPITTVTSNTTTITSKPTNVIASSSVT-DAPSVT 1181
            .:::..:|.||...|..|||           |..:|:..|.:...:..:|.....:|: ||....
Zfish   697 ESNSTLYGNFSLDDAAESNSTLYGNFSLNAEESNSTLHGNVSLDNTAESNSTLYGNVSLDAAEFN 761

  Fly  1182 TT---------NAVTSSTDPIGGLFSSVTI--------CKPNTPADTTKP-ANIFGGGLSAGSFS 1228
            :|         .|.:|||     |:.:||:        ...|...|.|:. :.:|      |:||
Zfish   762 STLQGNVSLDAAAESSST-----LYGNVTLDVADFNSTLHGNASLDATESNSTLF------GNFS 815

  Fly  1229 FGGTIDASKGLFGSTKPVATAPTSVTEANNKTDPISTTPSAISTTTATTTVSSPAVVPAAVTAAV 1293
            .....:::..|:|:....|....|....|     :|...:..|.:|....||..|
Zfish   816 LDDATESNSTLYGNVSLDAAESNSTLHGN-----VSLDAAEESNSTLYGNVSLDA---------- 865

  Fly  1294 PATSSTTVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPL-------AAKSPTATSTGNNS 1351
             |.|::|:.....:..:|..|:   |||....:......:::.|       ||:...:|..||.|
Zfish   866 -AESNSTLFGDFTLDDAAEEFN---STLYGNFSLHDDAESNSTLYGNVSLDAAEELNSTLYGNFS 926

  Fly  1352 ------SNSVFGGGFAVATSTAAPVASPF----QSAAKSPVSSANIFGSIPKAETSVFGGAT--- 1403
                  |||...|.|::...:.:.:...|    .:||:   |.:.:||.....:.:....:|
Zfish   927 LDDAAESNSTLYGNFSLDAESNSALYGNFTLDDDAAAE---SYSALFGDFTLDDAAEEFNSTLHG 988

  Fly  1404 ------TAPSNTT--------AAATPDAPPAG---LFASAAIS--------------NPSPFGSP 1437
                  ||.||:|        |||..::...|   |.|:|..|              |.:..|:.
Zfish   989 NFSLDDTAESNSTLYGNVNLDAAAKSNSTLQGNVSLDAAAESSSTLYGNVTLDVADFNSTLHGNI 1053

  Fly  1438 TTRAPASGGNIFG-------QAVKPSVFGQPA--QAGDSGGSIFGGGSASTPFGSSSIFGGGNTQ 1493
            :..|..|...:||       :....:::|..:  .|.:|..:::|..|.:....:|::.|..:..
Zfish  1054 SLDAAESNSTLFGDFTLDDAEESNSTLYGNFSLDDAAESNSTLYGNFSLNAAESNSTLHGNVSLD 1118

  Fly  1494 GAVGAPAAGSTSIFGQKVFGQSSAAAPAAGGNIFSNPVGSPQASPFGG-------GGNSIFGSPA 1551
            ..    |..:::::|......::.:.....|| ||.......::.:|.       ..::::|:.:
Zfish  1119 DT----AESNSTLYGNVSLDDAAESNSTLYGN-FSLDDAESNSALYGNFSLDDAESNSALYGNFS 1178

  Fly  1552 TAPPASGGSIFG--------GGSSSGGFGSFTQTTPAQ-------GGFGGGFGQGGGGSVAQTGF 1601
            .....|..:::|        ..|:|..||.||....|:       |.|  ........|.....|
Zfish  1179 LDDAESNSTLYGNFTLDDAAAESNSTLFGDFTLDDAAEEFNSTLHGNF--SLDDTESNSDLYGNF 1241

  Fly  1602 GSPQAPQQQTTTPGGFGAKPVFGGSPAFGASPTFGGGATFGSPK------------------GFG 1648
            ......:..:|..|.|..|.....:...|.:.:....||..|.:                  |.|
Zfish  1242 SLDDGAESNSTLYGNFSLKAAAESNSTLGGNFSLDDAATSNSTQHGNFSLVNSALKAVFDLLGVG 1306

  Fly  1649 GFGGASPVASPPPFGAAAKPAQGNIFETLGGQESG----LSFGNLAQTGNSNA 1697
            ....::.:.|.|......||   :.:......||.    :.:|:|:..||..|
Zfish  1307 NSKQSNQIPSVPGPNVPDKP---DPYSVSAFHESSADVLVVYGDLSNVGNPKA 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201
		WD40 repeat	38..86	CDD:293791
		WD40 repeat	90..131	CDD:293791
		WD40 repeat	139..173	CDD:293791
si:ch1073-263o8.2	XP_021324600.1	gp12-short_mid	<590..924	CDD:333253	68/321 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910