DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup214 and Nup214

DIOPT Version :9

Sequence 1:NP_652039.2 Gene:Nup214 / 46091 FlyBaseID:FBgn0010660 Length:1711 Species:Drosophila melanogaster
Sequence 2:XP_038960678.1 Gene:Nup214 / 296634 RGDID:1304977 Length:2085 Species:Rattus norvegicus


Alignment Length:2196 Identity:578/2196 - (26%)
Similarity:854/2196 - (38%) Gaps:627/2196 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DTQDFQFKLHHKIVAFKKCGE-PRSNVNLLAVSSSRGLLFAGSPTQPELKVIIVKDLVNAKSTAQ 73
            :.:||||:...|:..|....| |:...::|.||:..|:||||...  .|.|...|.|:.......
  Rat    13 EMKDFQFRALKKVRIFDSPEELPKERSSVLTVSNKYGMLFAGGTN--GLNVFPTKSLLIQNKPGD 75

  Fly    74 QP-------QARLVPLPSIPNYIACSSDG-NLLAVNHTQNGTSLLSIYAVLSFMT---PDVRP-- 125
            .|       |...||:....:::|.|.|. .|.|...:....|:::.:.|.:|..   |..||  
  Rat    76 DPNKIVDTIQGLNVPMKFPVHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFT 140

  Fly   126 VYNIRLAAEDHVHGVQLLWNPVLPNSLAVVLSNGALAMYALKEGGNFEMHSLDKNQQVKCGCWSP 190
            .:.:...|...|:.::  |||.:|:..||.|::|::::..:.:.... ..:|..:..|.|.||||
  Rat   141 YHKLSNGASGMVNDMK--WNPTVPSMAAVCLADGSISVLQVTDVVKV-CATLPPSSGVTCVCWSP 202

  Fly   191 KGKQIVLGFPGGTVKQFKPDLTLAKTLLCPPNIH-DAPFDTIAIQWLSTFQFAVIFLQHGED--- 251
            ||||:.:|...|||.|:.|.|...|.:.|||... |.|...:.:.|:.|:.|.:::.  |.|   
  Rat   203 KGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYEADHPVRVLDVLWIGTYVFTIVYA--GADGAL 265

  Fly   252 --CSPSLYILNAPKAGAPS---YINYYDICYSMNGPRNHQFVFSHVPQWNLLLVVSANGVEVGIM 311
              | |.:.:...||.....   ::|:.:.|||....|.|.:..|::.:|:|:|..||...||.|:
  Rat   266 ETC-PDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSIL 329

  Fly   312 RSTEAGDTPAWQQLTLLDEARIEMPLSEDKDETFPLGFAFDTSTTHQLTINEKK-LQTMPMVHVL 375
              ....|...|:...|.|.:|.|:|:::..|::.|:|.|.|.:...::.|||:| |...|::.:|
  Rat   330 --ARQSDQTNWESWVLEDSSRAELPVTDKSDDSLPVGVAIDYTNEVEVAINEEKTLPPAPVLLLL 392

  Fly   376 SSDGELLSFNFLNVLPTAVSV----------------------CSPPPPVADTSGQFKPLNMLLA 418
            |:||.|..|..:|..|...|:                      .:||.|.|       |.|:   
  Rat   393 STDGVLCPFYMINQNPGVRSLIKTLELISAEGERQPKSSGSFPSTPPSPQA-------PQNL--- 447

  Fly   419 SEEEEQPAWAASP----SKAPAAT---PAASSDIS-FAFTPNTVTSTPAPSKDKQPSLFSGFGAA 475
                :.||.|:||    |.||.||   |:|....| |:|.|:...|:..|.:.......|....|
  Rat   448 ----DAPATASSPLPPVSAAPTATFPLPSAGGGPSVFSFGPSPFKSSSIPGEPPPYPTGSDSSRA 508

  Fly   476 AAKAPAPQLSFGTAP----TSSPVSFGAPTTNAAKPTTPFGGFG----------TQATTTAMGSM 526
            |..:..|..||  ||    |.:|....||...:|.|.| ||..|          :.|..|.|...
  Rat   509 APASGTPTFSF--APPSKGTLAPTPAVAPVPTSAAPFT-FGSSGFKPPLESTPMSSAPNTGMKPS 570

  Fly   527 FSASGANA-------FGGMALNKPAIASVTPRTAAPGSTVPATPASAPANKPLYTVPLTFTP--V 582
            |..|.::.       |..:|.:.|..:|.:..:..|.|:.|..|||.|.:.|   .||..:|  :
  Rat   571 FPPSTSSVKVNLNEKFTAVASSAPVHSSTSIPSVLPFSSSPKPPASGPLSHP---TPLPASPSSM 632

  Fly   583 DTKPATSAPPQIA-------------------------------DESLKPDDTE----------P 606
            ..||:.|..|.:.                               ..:|:|..||          |
  Rat   633 PLKPSVSPSPSVGRSAQTAPSSAPSTGQKSPRVNPPVPKSGSSQARALQPPVTEKQRHQWKESDP 697

  Fly   607 IIKDMIALQIEAFSKDIQKQKEQTKELLKGIAAPSALRAYAKRLDDLQ----ELNEQAKDVEFEL 667
            ::.. |..:|..|.|::::.|.:|.:....:..|..::......|||.    |:.|..:.:..  
  Rat   698 VMAG-IGEEIAHFQKELEELKARTSKACFQVGTPEEMKMLRTESDDLHTFLFEIREATESLHG-- 759

  Fly   668 DVQGLRQGLNEAYAIVAECR---------GKLE-IYRKPEITRLMNSSSCDPSGRRML---ARLQ 719
            |:..|:..|.|.:|.|.|.|         |.|. :|::|          .||.....|   .||.
  Rat   760 DISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRP----------LDPKSEAQLQEIRRLH 814

  Fly   720 SYVAANEAQLRLAQQHV----DLQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIV 780
            .||       :.|.|.|    ||:|::..:..:|  :.|:.:|..|.::..|...:.:.:.||..
  Rat   815 QYV-------KFAVQDVNDVLDLEWDRHLEQKKR--QRRLIVPERETLFNTLANNREIINQQRKR 870

  Fly   781 QNNIKSKLKERGLLQAALLDQ----EKSRTRTNEAVDTLTDSILTMSLSQVVDSNA-------AK 834
            .|::...|:     |..|.:|    .:..|.:.::.....||.|...|...::|:.       .|
  Rat   871 LNHLVDSLQ-----QLRLYNQTSPWNRPSTLSTQSDTPSFDSDLEHLLKTTIESHTKPSPRVPGK 930

  Fly   835 LTRERLQKIRNIVQLQKINVICPQRPDRVGLKSEVILETKRRAEQIKRAAAKPATANKYTQAAVA 899
            |:..:..::||.:..:|...:....|  ..|.....| ::|..|.:...::..:.|:        
  Rat   931 LSPAKQAQLRNFLAKRKTPPVRSTAP--ASLSRSAFL-SQRYYEDLDEGSSASSVAH-------- 984

  Fly   900 PPSPPDVAPTP------AVAPMPQATVTVAPP------LPKPMPSIPSVVEKPGVPTHPTTPVAT 952
            |....|..|||      ||.|:|:....|..|      ||:.||     ..||.: .|.::|.|.
  Rat   985 PLEGEDARPTPTCREEEAVVPVPRHAPVVRTPSVQPSLLPQAMP-----FAKPHL-IHSSSPAAM 1043

  Fly   953 PFSFSQS----IPFVKTSTVTPTTNTVTPGEAAKPGLSIFGGSTISSFSFGGGAAKSAL--SFGT 1011
            ..|.|.|    ||....:|:. .|.||..|   .||.|    .|:::   ...||.:||  ...:
  Rat  1044 SSSISTSATKVIPQGADTTML-ATKTVKHG---APGPS----HTVAA---PQAAAAAALRRQMAS 1097

  Fly  1012 GSPAVAAPT-------------------PKP-------------------------NPLSAVEKP 1032
            .:|||:..|                   |.|                         .|.||.:.|
  Rat  1098 QAPAVSTLTESTLKNVPQVVNVQELKSNPSPPSAAMGKFTCCPTEDLDGPLRTNSSGPHSAAKAP 1162

  Fly  1033 ----TP---------------EPTKPKEQKAAESKEFKAVQPET--EESKVPQKPKAETENKSFG 1076
                ||               :|:.|.......|...|||.|.|  .||.|...|.....||.|.
  Rat  1163 HAVLTPVAASQAKQGSLINSFKPSGPTPVSCQLSSGDKAVGPGTAKTESPVTSTPSTGQLNKPFS 1227

  Fly  1077 F----------------GGFTGTGGTVGNTSSS----PFSFGGLGSSLGF-----GGTAAAVPKS 1116
            |                ..||.|.|....|..|    .|||||.|..  |     |...|..|.|
  Rat  1228 FASPGTFTFGTITPAPSSSFTATPGAAPPTKESNQLEAFSFGGGGKP--FCETIPGNPPATGPPS 1290

  Fly  1117 EPS-STATTSVATSASTAPFGIFSAALAKPSNSE-PITTVTSNTTTITSKPTNVIASSS------ 1173
            .|| |..|||:..||.|:         :||:..| |::|.:|...|..||...::..||      
  Rat  1291 APSTSVTTTSLEDSAPTS---------SKPATPETPVSTASSKLETPPSKLGELLFPSSLAGETL 1346

  Fly  1174 -------VTDAPSVTTTNAVTSSTD--------PIGGLF-----------SSVTICKPNTP---- 1208
                   |..|...|...:..|||:        |.|..|           .|||...|..|    
  Rat  1347 GSFSGLRVGQAEESTKPVSKASSTNLAGAQPAKPSGFSFPAASVLGKPVEPSVTSSAPAAPVSAL 1411

  Fly  1209 --ADTTKPANIFG-----GGLSAGSFSF-GGTIDASKG--LFGSTKPVATAPTSVTEANNKTDP- 1262
              :.::..|.:||     ....:|..|| |.::.:||.  .||:.:..:.|..:.|.|:....| 
  Rat  1412 SASTSSSSATVFGSVPLTSAAPSGLMSFSGASLASSKASFSFGNQQTSSAAAAAATPASTSVAPS 1476

  Fly  1263 ------------ISTTPSA----ISTTTATTTVSSPAV--------------------------- 1284
                        :.::|||    :|:...|...:.|||                           
  Rat  1477 LPASFPTLSFGGLLSSPSASSLPVSSGKITEEATPPAVPDKSDHSEVSASTPSLPLQPPSAQLPQ 1541

  Fly  1285 -------------VPAAVTAAVPATSSTTV--TSSTAV-PGSAFSFSNAFS-------------- 1319
                         |||..|.:.|::|::.|  |.||.| ||...|.:.|.|              
  Rat  1542 ASLQTSDPVKKEPVPAQTTDSRPSSSASLVASTESTPVAPGGPDSKTEAVSPASTFAGPGPAVVA 1606

  Fly  1320 --TLSAGGAAAP---TTSASAPLAAKSPT-ATSTG----NNSSNSVFGGGFAVATSTA------- 1367
              .|.||.||:.   |.|.|:.:::.:|| ||.|.    ..|.:|||....|.::|:|       
  Rat  1607 AVLLGAGSAASEASGTPSTSSTVSSSTPTPATETAVFGTATSGSSVFTQPPAASSSSAFNQLSSN 1671

  Fly  1368 ---APVASPF---------QSAAKSPVSSAN-------------IFGSIPKAETSVFGGATTAPS 1407
               ||.|:|.         .:||.:|.:|::             :||.....::..||.||::|:
  Rat  1672 TATAPSATPVFGQVAASIASTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQSPAFGQATSSPA 1736

  Fly  1408 N----------------TTAAATPDAPPAGLF-ASAAISNPS--PFGSPTTRAPASGGNIFGQAV 1453
            :                .:.::||.:..|.:| |:::.|:|.  .||..:|.   :||.:|||. 
  Rat  1737 SGFSFSQPGFSSVPAFGQSVSSTPTSTSANVFGATSSTSSPGSFSFGQASTN---TGGTLFGQN- 1797

  Fly  1454 KPSVFGQPAQAGDSGGSIFGGGSAST----PFGSS----SIFGGGNTQGAVGAPAAGSTSIFGQK 1510
            .|..|||....| .|||:||..||:|    |.|.|    |.||..||....|..|:...|:|||:
  Rat  1798 NPPAFGQSPGFG-QGGSVFGSTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAASSGGSVFGQQ 1861

  Fly  1511 -------VFGQSSAAAPAAGGNIFSNPVGSP-----QASPF--GGGGNSIFGSPATAPPASGGSI 1561
                   |||..:|   ..||..||...|.|     ..:||  ..||   |||   .|..:..::
  Rat  1862 SSTSSGSVFGSGNA---TRGGGFFSGLGGKPSQDAANKNPFSSASGG---FGS---TPTPNTSNL 1917

  Fly  1562 FG--GGSSSGGFG-SFTQTTPAQGGFGGGFGQGGGGSVAQTGFGSPQAPQQQTTTP---GGFGAK 1620
            ||  |..:.|||| ||.:..||      |....||||||..|||        .:||   |||||.
  Rat  1918 FGNSGAKTFGGFGSSFGEQKPA------GTFSSGGGSVASQGFG--------FSTPNKTGGFGAA 1968

  Fly  1621 PVFGGSPAFGASPTFGGGATFG------SPKG------FG-----------GFGGASPVAS---- 1658
            ||||..|.||.||.|||...||      ||.|      ||           |||.:|..||    
  Rat  1969 PVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTASFGTL 2033

  Fly  1659 ----PPPFGAAAKPAQGNIFETLGGQESGLSFGNLAQT-GNSNAQKPAFGG 1704
                .|.||:.::...|  |.|.....||...|..|.| |:||:....|||
  Rat  2034 ASQNAPTFGSLSQQTSG--FGTPSSGFSGFGSGTGAFTFGSSNSSVQGFGG 2082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup214NP_652039.2 WD40 <31..>233 CDD:225201 62/215 (29%)
WD40 repeat 38..86 CDD:293791 16/54 (30%)
WD40 repeat 90..131 CDD:293791 11/46 (24%)
WD40 repeat 139..173 CDD:293791 8/33 (24%)
Nup214XP_038960678.1 WD40 23..>216 CDD:421866 59/206 (29%)
WD40 repeat 39..86 CDD:293791 16/53 (30%)
WD40 repeat 96..147 CDD:293791 11/56 (20%)
WD40 repeat 152..189 CDD:293791 7/36 (19%)
ANAPC4_WD40 155..>216 CDD:403945 22/60 (37%)
WD40 repeat 196..230 CDD:293791 14/34 (41%)
WD40 repeat 243..291 CDD:293791 13/55 (24%)
WD40 repeat 304..350 CDD:293791 13/45 (29%)
PHA03247 <425..688 CDD:223021 83/338 (25%)
PHA03247 <1126..1603 CDD:223021 183/683 (27%)
COG5651 <1784..2081 CDD:227938
Nup214_FG 1913..1972 CDD:408399
Nucleoporin_FG2 <1947..2053 CDD:406391


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3630
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006508
OrthoInspector 1 1.000 - - oto96859
orthoMCL 1 0.900 - - OOG6_106765
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5483
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
87.670

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