DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup214 and nup124

DIOPT Version :9

Sequence 1:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_593213.1	Gene:	nup124 / 2542254	PomBaseID:	SPAC30D11.04c	Length:	1159	Species:	Schizosaccharomyces pombe

Alignment Length:	1381	Identity:	325/1381 - (23%)
Similarity:	480/1381 - (34%)	Gaps:	400/1381 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 PPVADTSGQFKPLNMLLASEEEEQPAWAASPSKAPAAT--PAASSDISFAFTPN-TVTSTPAPSK 462
            |||:.        |...:|:..::|......|..|..|  ..|.|.:...||.. ...::...||
pombe     2 PPVSK--------NTRTSSKTVKKPYDPPQGSSRPFFTVLKRAFSSVLHPFTSGLDEKASGTASK 58

  Fly   463 DKQPSLFSGFGAAAAKA-PAPQLS---FGTAPTSSPVSFGAPT-----------TNAAKPTTPFG 512
            |::.      |.|..|: ..|:|:   .|.:|....||..:..           ||..:|..|
pombe    59 DRKS------GRAGTKSLLTPELTPHYLGKSPRIIRVSNRSHVRTIDGIEEKVHTNTFEPRKP-- 115

  Fly   513 GFGTQATTTAMGSMFSASGANAFGGMALNKPAIASVTPRTAAP---GSTVP---ATPASAPA--- 568
              ..:...|...::|....       .|:..::.|:.|.:|..   |||..   |||.|:.:
pombe   116 --KQKQDYTNSPTLFKRHD-------ELSLKSLNSLHPSSALSKKLGSTSQHQIATPKSSASLLN 171

  Fly   569 ------NKPLYTVPLTFTPVD-----------TKPATSAPPQIADES--LKPDDTEPIIKDMIAL 614
                  ::...|:.::....|           .||:.|..|.::.:.  .:..:.||..|
pombe   172 ILRSLHDEQKNTLNISSVKQDRITEANPTCEKRKPSRSPSPMLSKKKSVARASENEPSAK----- 231

  Fly   615 QIEAFS-KDIQKQKEQTKELLKGIAAPSALRAYAKRLDDLQELNEQAKDVEFE-LDVQGLRQGLN 677
            |.::|| .|..|.....::...|....||......|....:..:::...:.:| |:...||:.:
pombe   232 QNKSFSGNDSHKSLTDIRDKENGETEVSAKNHVPHRSSRRRRRHQRLIPIIYETLEQMDLRKPV- 295

  Fly   678 EAYAIVAECR-----GKLEIYRKPEITRLMNSSSCDPSGRRMLARLQSYVAANEAQLRLAQQHVD 737
               .:.||.:     |......|.:|...:::    |:.|:.....:.::.|..|        ||
pombe   296 ---LVNAEVQTDSNPGNTMFIDKQDIYHRLST----PTSRKRQTLEKGHIKAFSA--------VD 345

  Fly   738 LQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIVQNNI---KSKLKERGLL-QAAL 798
               |...::          ..|.:.::......|| ..::||::..|   |....::||| ::|.
pombe   346 ---EDLDEI----------FACEDDVHYTALPKQN-PKSERILEPIIASPKDNTSDKGLLTKSAP 396

  Fly   799 LDQEKSRTRTNEAVDTL-TDSILTMSLSQVVDSNAAKLTRERLQKIRNIVQLQKINVICPQRPDR 862
            ..:|...:.|.:.|.|. .|:.||  |:...|:..  ...:.|.|
pombe   397 TFEELQASITPKPVKTSPNDTALT--LANAEDNKT--FEHQPLSK-------------------- 437

  Fly   863 VGLKSEVILETKRRAEQIKRAAAKPATANKYTQAAVAPPSP-----------------PDVAPT- 909
                     :|:....|...:..|.:|..|   :.|.||||                 |....|
pombe   438 ---------DTEAPKSQFSSSPTKESTTRK---SEVEPPSPSKEIKSSHFSVPEFKFEPKTEATT 490

  Fly   910 ------PAVAPMPQATVTVA-------PPLPKPMPSIPSVVEKPGVPTHPTTPVAT---PFSFSQ 958
                  |.....|.||..|.       .|.|.....:||..::        ||..|   |..|||
pombe   491 DKKLNVPKFEFKPTATADVQTNRLKENEPKPTFFAQLPSKTQE--------TPSITENKPSFFSQ 547

  Fly   959 SIPFVKTSTVTPTTNTVTPGEAAKPGLSIFGGSTISSFSFGGGAAKS----------ALSFGTGS 1013
            ..|  |........|  .|...|          :.|.|||||.|.|:          ..:|...:
pombe   548 LSP--KREETEKKDN--APSAPA----------STSGFSFGGFAPKTLEEKEETKAPTFNFSLNN 598

  Fly  1014 PAVAAPTPKP----NPLSAVEKPTP---EPTKPKEQKAAESKEFKAVQPETEESKVPQKPKAETE 1071
            .:....|.||    |..|:..|||.   ...|..|...|.|......:|...|||
pombe   599 ASSTQDTTKPTLQFNFGSSFGKPTSNIFNDKKTSENGLASSTVASESKPSAPESK---------- 653

  Fly  1072 NKSFGFGGFTGTGGTVGNTSSSPFSFGGLGSSLGFGGTAAAVPKSEPSSTATTSVATSASTAPFG 1136
             .|.|||...|         ||||||.....|.....|.:.....:....|..|::..||| ||
pombe   654 -PSSGFGNTAG---------SSPFSFNLTKESKEVPPTNSFSFAKKGKDEANDSLSAKAST-PF- 706

  Fly  1137 IFSAALAKPSNSEPITTVTSNTTTITSKP-----TNVI------------------------ASS 1172
                :.||| |:|.:||.....:...:||     ||::                        .:|
pombe   707 ----SFAKP-NTENVTTTAPQFSFNFTKPNTDAKTNLLPEKTFNEEAVKQKETEKEVPPTGPKAS 766

  Fly  1173 SVTDAPSVTTTNAVTSSTDPIGGLFSSVT--ICKPNTPADTTKPANIFGGGLSAGSFSFGGTIDA 1235
            .:.|  ||::.|||.|||......|::|:  ..:.|.|.||||...      :|...:...|.||
pombe   767 EIKD--SVSSNNAVPSSTFNFVSPFAAVSEKTNENNIPNDTTKTNG------NATKRTLEQTEDA 823

  Fly  1236 SKGLFGSTKPVATAPTSVTEANNKTDPIS--TTPSAISTTTAT--TTVSSPAVVPAAVTAAVPAT 1296
                    ||.|.:..|.||..||....|  ||...:.|::.|  .|.::|....:|..|..|:|
pombe   824 --------KPFAFSFGSTTEQANKKASTSNETTKPQLDTSSKTDGVTANAPFSFASAFNAPKPST 880

  Fly  1297 SST---TVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSPTATSTGNNSSNSVFGG 1358
            ::.   ...|:...|..||||.|. |.:.|.....|:|::|.     :|.:..|.|..:.| ||.
pombe   881 NTADGKDSASNLTTPSPAFSFGNN-SGVKASSNNNPSTNSST-----APFSFGTSNKPAFS-FGS 938

  Fly  1359 GFAVATST-AAPVASPFQSAAKSPVSSANIFG----SIPKAETSVFGGATTAPSNTTAAATPDAP 1418
            ..:..||. .||.||   ::|.:|.:||..||    |:.|.|.                 ||.|.
pombe   939 ATSKTTSEGTAPAAS---ASAPAPTTSAFSFGASNSSMNKEEN-----------------TPMAK 983

  Fly  1419 PAGLFASAAISNPSPFGSPTTRAPASG---GNIFGQAVKP---SVFGQPAQAGDSGGSIFGGGSA 1477
            .||                 ..|||||   |..||....|   |:||....| .|....||..|.
pombe   984 DAG-----------------DTAPASGFKSGFSFGANNSPQPASMFGTSTPA-PSSAFAFGNQSG 1030

  Fly  1478 STPFGSSSIFGGGNTQGAVGAPAAGSTSIFGQKVFGQSSA---AAPAAGGNIFSNPVGS----PQ 1535
            :.|...:. |||.........|:.|.|       |..|:|   |||..|.....||.||    .|
pombe  1031 TNPAAPAG-FGGITNTATNNPPSTGFT-------FTPSNAGSTAAPMFGAGNTPNPSGSINNASQ 1087

  Fly  1536 ASPFGGGGNSIFGSPATAPPASGGSIFGGGSSSGGFGSFTQTTPAQGGFGGGFGQGGGGSVAQTG 1600
            |..||.|..|   :||:.||::|.|.  |.::...|.:....:||..|.             |..
pombe  1088 AFAFGSGEPS---NPASNPPSTGFSF--GAATPSAFNASASQSPAPNGI-------------QFN 1134

  Fly  1601 FGSPQAPQQQTTTPGG 1616
            .||..:   ||..|.|
pombe  1135 LGSSNS---QTNAPPG 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201
		WD40 repeat	38..86	CDD:293791
		WD40 repeat	90..131	CDD:293791
		WD40 repeat	139..173	CDD:293791
nup124	NP_593213.1	Nup_retrotrp_bd	1072..1158	CDD:287557	28/97 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23193
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100