Protein Alignment Nup214 and nup146

DIOPT Version :9

• Sequence 1: NP_652039.2
• Gene: Nup214 / 46091
• FlyBaseID: FBgn0010660
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_594543.1
• Gene: nup146 / 2541507
• PomBaseID: SPAC23D3.06c
• Length: 1325
• Species: Schizosaccharomyces pombe
• Alignment Length: 1397
• Identity: 273/1397 - (19%)
• Similarity: 454/1397 - (32%)
• Gaps: 472/1397 - (33%)

  Fly     4 NAPDCEDTQDFQFKLHHKIVAF----------------KKCGEPRSNVNLLAVSSSRGLLFAGSP 52
            |.|:...:|..:.::..:.:.|                ...|.|..: ||.|:::.:.|..||.|
pombe    13 NEPNAGGSQVTESEIEEEDIEFLSFAALKIGATSSLSNSSLGLPEYS-NLFAINNLKSLFVAGVP 76

  Fly    53 T--------QPELKVIIVKDLVNAKSTAQQPQARLVPLPSIPNYIACSSDGNLLAVNHTQNGTSL 109
            .        ..:..:|...:.|:|.........|.|.||          |.....|:.:.||..:
pombe    77 NYLIIGSTLDLQKSLIDADENVDANVLKDSASIRHVSLP----------DAKFSMVSFSSNGEFV 131

  Fly   110 ---------LSIYAVLSFMTPDVRPVYNIRLAAEDHVHGVQLLWNPVLPNSLAVVLSNGALAMYA 165
                     ||:|...:.:......:|  :....|.   ||:|.||.:.|  .|:|.|..|.::.
pombe   132 IAYDFVSFELSVYETDALLKNSATSIY--KAVFPDL---VQVLPNPEINN--LVILRNLKLEVFL 189

  Fly   166 LKEGGNFEMHSLDKNQ-------QVKCGCWSPKGKQIVLGFPGGTVKQFKPDLTLAKTLLCPPNI 223
            |         ||.|.|       ...|..||.:|||.|:||..||:.|:.|...:...:..||::
pombe   190 L---------SLSKFQVESPLAKDATCAAWSRRGKQCVIGFNNGTMSQYTPAGEIKLRIPRPPSL 245

  Fly   224 HDAPFDTIAIQWLSTFQFAVIFLQHGEDCSPSLYILNAPKAGAPSYINYYDICYSMNG------- 281
            .:  :....|.|:...:|.|.:       || |..|:......|.....:.|...|||
pombe   246 EN--YFVECISWIENREFVVFY-------SP-LTSLSNESDEPPHESECFVISVGMNGHFNFGKA 300

  Fly   282 -----------PRNHQFVFSHVPQW-----NLLLVVSANGVEVGIMR-STEAGDTPAWQQLTLLD 329
                       .|:|.::.| :..|     :|::|.:....::|::. |.|...   |..|.::|
pombe   301 GDPTPPFGAVNRRDHHYIAS-LHAWKPDLRSLVVVANTASADLGVLALSMEKNQ---WSILNIVD 361

  Fly   330 EA-RIEMPLSEDKD-ETFPLGFAFDTSTTHQLTINEKKL---------QTMPMVHVLSSDGELLS 383
            |. |..:|.|..|| ::.|.....|.:.|.:::   |.|         ..:|:|.|.:.:.:|::
pombe   362 ETKRASLPYSNKKDSDSSPTALVMDFTATDRIS---KPLDPTEAPADCSPLPIVWVFNDEFQLVA 423

  Fly   384 FNFLNVLPTAVSVCSPPPPVADTSGQFKPLNMLLASEEEE--QPAWAASP-------SKAPAATP 439
            :........:.|:..|...|.....:...:.   ||..|.  .|...|||       :.:|.:..
pombe   424 YRIFYADAISKSIDYPEMNVIKDKNKDSTVR---ASNNENIPTPDKQASPFVKNLSSTSSPFSQS 485

  Fly   440 AASSDISF----AFTPNTVTSTPAPSKDK-----QPSLFSG---FGAAAAKAPAP---------- 482
            :|..:..|    :|.....|...:.:|..     |||.|..   ||..:|...||
pombe   486 SAFGNFKFGQATSFDKGLSTDASSGAKSNTPVFGQPSTFGQAPVFGQPSAFGQAPVFGQPSAFGQ 550

  Fly   483 -QLSFGTAPTSSPVSFGAPTTNAAKPTTPFGGFGT-QATTTAMGSMFSASGANAFGGMA------ 539
             ..||||:..:..:.||.       ..:|..|..| :|.|....::.||||..:|.|.|
pombe   551 SSFSFGTSNMNQKLDFGT-------FKSPLSGAATGEAKTNLEKAVTSASGKASFTGFAPSQSTT 608

  Fly   540 --LNKPAIASVTPRTAAPGSTVPATPASAPANKPLYTVPLTFTPVDTKPATSAPPQIADESLKPD 602
              ||..:|.......:..||                      :.|.||..:..  |.::.:|..|
pombe   609 SGLNFDSIPKDNEAASIFGS----------------------SQVSTKNTSGF--QFSNNTLLAD 649

  Fly   603 DTEPIIKDMIALQIEAF-SKDIQKQKEQT--KELLKGIAA----PSALRAYAKRLDDLQELNEQA 660
            :.:..|:.....:||.. :.|::...||.  .::..|.:.    |....::...|||  :.|...
pombe   650 NVDEDIESDHDTKIEELANSDVEPSTEQNIGGDVSWGASTFQSKPQPSFSFGLTLDD--KSNTPG 712

  Fly   661 KDVEFELDVQGLRQGLNEAYAIVAECRGKLEIYRKPEITRLMNSSSCDPSGRRMLARLQSYVAAN 725
            |:...              :...||.:.:   .:|||...|....|..||.:.|.|
pombe   713 KNFSI--------------FGKTAETQVE---QKKPENNVLTKPFSFAPSDKSMFA--------- 751

  Fly   726 EAQLRLAQQHVDLQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIVQNNIKSKLKE 790
             |.:..|.:.:|.|         :.||:                                  |..
pombe   752 -ANIPSAGEGLDQQ---------KTSKA----------------------------------LPS 772

  Fly   791 RGLLQAALLDQEKSRTRTNEAVDTLTDSILTMSLSQVVDSNAAKLTRERLQKIRNIVQLQKINVI 855
            .|:.:.:..|.||:.                       :||..|                ..|..
pombe   773 TGITKLSENDNEKAE-----------------------ESNETK----------------GFNTT 798

  Fly   856 CPQRPDRVGLKSEVILETKRRAEQIKRAAAKPATANKYTQAAVAPPSPPDVAPT---PAVAPMPQ 917
            ..::.|: ..|||.           |.:.|..:..||.|....:...|...:|.   .|.||
pombe   799 IAKQNDK-SSKSEG-----------KASVANMSALNKSTNNETSDSKPSLKSPLFNFSADAP--- 848

  Fly   918 ATVTVAPPLPKPMPSIPSVVEKPGVPTHPTTPVATPFSFSQSIPFVKTSTVTPTTNTVTPGEAAK 982
             |.|...|...|                       ||||::  |.|:..:....::|
pombe   849 -TFTFNKPSETP-----------------------PFSFNK--PLVEKESKQDVSDT-------- 879

  Fly   983 PGLSIFGGSTISSFSFGGGAAKSALSFGTGSPAVAAPTPKPNPLSAVEKPTPEPTKPKEQKAAES 1047
                    |..|.|||        .:||               :.:.:.||||||:..|...:|.
pombe   880 --------SDRSPFSF--------KAFG---------------IDSKKSPTPEPTEMAESNISEE 913

  Fly  1048 KE-FKAVQPETEESKV-----------------PQK-------------PKAETENKSFGFGGFT 1081
            .| :|.::....||::                 |.|             ||.:.:..||    |.
pombe   914 SEGWKLIEQPNVESEIEDQDEESSDLNGKRRSTPPKIHEVGVNKMLDVVPKEKRDLNSF----FP 974

  Fly  1082 GTGGTVGNTSSSPFS-----FGGLGSSLGFGGTAAA--VPKSEPSSTATTSVATSASTAPFGIFS 1139
            .....|.:|..:...     ...:.|:.||....||  :.:.||.|:....:|||.:.....:|.
pombe   975 KQPLVVQSTDKNKKEPQESLEDEILSAEGFSEVEAANKISRFEPFSSPKLKLATSDNAPEKYVFE 1039

  Fly  1140 --------------------AALAKPSNSEPITTVTS---------NTTTITSKPTNVIAS--SS 1173
                                |.|.:..::|.:..|.:         |...:..:..|:||.  ..
pombe  1040 ESESSDLEEGPVPLRNLESLADLPEAESNEKLPMVNTFERLYLQFKNELDLVWQNINIIAEYIEG 1104

  Fly  1174 VTDAPSVTTTNA----VTSSTDPIGGLFSSVT 1201
            .|..||..:..|    ::.:|:.:..|..:||
pombe  1105 QTSTPSAVSEQATMAMLSQNTEELEDLLDTVT 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201	54/225 (24%)
		WD40 repeat	38..86	CDD:293791	12/55 (22%)
		WD40 repeat	90..131	CDD:293791	8/49 (16%)
		WD40 repeat	139..173	CDD:293791	11/33 (33%)
nup146	NP_594543.1	NUP214	62..418	CDD:293360	90/398 (23%)
		Nucleoporin_FG	495..585	CDD:290362	23/96 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3630
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006508
OrthoInspector	1	1.000	-	-		oto101145
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R851
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930