DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup214 and Nup214

DIOPT Version :9

Sequence 1:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_006498008.1	Gene:	Nup214 / 227720	MGIID:	1095411	Length:	2086	Species:	Mus musculus

Alignment Length:	2183	Identity:	561/2183 - (25%)
Similarity:	849/2183 - (38%)	Gaps:	600/2183 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DTQDFQFKLHHKIVAFKKCGE-PRSNVNLLAVSSSRGLLFAGSPTQPELKVIIVKDLVNAKSTAQ 73
            :.:||||:...|:..|....| |:...::|.:|:..|:||||...  .|.|...|.|:.......
Mouse    13 EMKDFQFRALKKVRIFDSPEELPKERSSVLTISNKYGMLFAGGTN--GLNVFPTKSLLIQNKPGD 75

  Fly    74 QP-------QARLVPLPSIPNYIACSSDG-NLLAVNHTQNGTSLLSIYAVLSFMT---PDVRP-- 125
            .|       |...||:....:::|.|.|. .|.|...:....|:::.:.|.:|..   |..||
Mouse    76 DPNKIVDTIQGLNVPMKFPVHHLALSCDSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFT 140

  Fly   126 VYNIRLAAEDHVHGVQLLWNPVLPNSLAVVLSNGALAMYALKEGGNFEMHSLDKNQQVKCGCWSP 190
            .:.:...|...|:.::  |||.:|:.:||.|::|::::..:.:.... ..:|..:..|.|.||||
Mouse   141 YHKVSNDASGMVNDMK--WNPTVPSMVAVCLADGSISVLQVTDVVKV-CATLPPSTGVTCVCWSP 202

  Fly   191 KGKQIVLGFPGGTVKQFKPDLTLAKTLLCPPNIH-DAPFDTIAIQWLSTFQFAVIFLQHGED--- 251
            ||||:.:|...|||.|:.|.|...|.:.|||... |.|...:.:.|:.|:.|.:::.  |.|
Mouse   203 KGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFTIVYA--GADGTL 265

  Fly   252 --CSPSLYILNAPKAGAPS---YINYYDICYSMNGPRNHQFVFSHVPQWNLLLVVSANGVEVGIM 311
              | |.:.:...||.....   ::|:.:.|||....|.|.:..|::.:|:|:|..||...||.|:
Mouse   266 ETC-PDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSIL 329

  Fly   312 RSTEAGDTPAWQQLTLLDEARIEMPLSEDKDETFPLGFAFDTSTTHQLTINEKK-LQTMPMVHVL 375
              ....|...|:...|.|.:|.|:|:::..|::.|:|.|.|.:...::||||:| |...|::.:|
Mouse   330 --ARQNDQTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLL 392

  Fly   376 SSDGELLSFNFLNVLPTAVSVCSPPPPVADTSGQFKPL---------NMLLASEEEEQPAWAASP 431
            |:||.|..|..:|..|...|:......:: |.|:.:|.         :...|.:..:.||.|:||
Mouse   393 STDGVLCPFYMINQNPGVRSLIKTLELIS-TEGERQPKSSGSFPGTPSSPQAPQNLDAPATASSP 456

  Fly   432 ----SKAPAAT----PAASSDISFAFTPN------TVTSTPA--PSKDKQPSLFSGFGAAA-AKA 479
                |.||.:|    .||.|...|:|.|:      :||..|.  |:.........|.|.:. :.|
Mouse   457 LPPVSAAPTSTFPMPSAAGSPSVFSFGPSSFKSSASVTGEPPLYPTGSDSSRAAPGSGTSTFSFA 521

  Fly   480 PAPQLSFGTAPTSSPV-SFGAPTTNAAKPT---TPFGGFGTQATTTAMGSMFSASGANA------ 534
            |..:.|..:.|..:|| :..||.|...|||   ||.    :....|.|...|..|.::.
Mouse   522 PPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPM----SSTPNTGMKPSFPPSASSVKVNLNE 582

  Fly   535 -FGGMALNKPAIASVTPRTAAPGSTVPATPASAPANKPL------YTVPLTFTPVDTKPATSAPP 592
             |..:|.:.|..:|.:..:..|.|:.|...||.|.:.|.      .::||. :.|...||.....
Mouse   583 KFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLK-SSVSPSPAAGRST 646

  Fly   593 QIADES-------------------------LKPDDTE---PIIKDM------IALQIEAFSKDI 623
            |.|..|                         |:|..||   |..||.      |..:|..|.|::
Mouse   647 QTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKEL 711

  Fly   624 QKQKEQTKELLKGIAAPSALRAYAKRLDDLQ----ELNEQAKDVEFELDVQGLRQGLNEAYAIVA 684
            ::.|.:|.:....:.....::......|||.    |:.|..:.:..  |:..|:..|.|.:|.|.
Mouse   712 EELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHG--DISTLKTTLLEGFAGVE 774

  Fly   685 ECR---------GKLE-IYRKPEITRLMNSSSCDPSGRRML---ARLQSYVAANEAQLRLAQQHV 736
            |.|         |.|. :|::|          .||.....|   .||..||       :.|.|.|
Mouse   775 EAREQHGRNHDSGYLHLLYKRP----------LDPKSEAQLQEIRRLHQYV-------KFAVQDV 822

  Fly   737 ----DLQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIVQNNIKSKLKERGL---- 793
                ||:|::..:..:|  :.|:.:|..|.::..|...:.:.:.||...|.:...|::..|
Mouse   823 NDVLDLEWDRHLEQKKR--QRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHT 885

  Fly   794 ----LQAALLDQEKSRTRTNEAVDTLTDSILTMSLSQVVDSNA-------AKLTRERLQKIRNIV 847
                |.:||..|..|.:         .||.|...|...::|:.       .||:..:..::||.:
Mouse   886 APWSLPSALSTQSNSHS---------FDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFL 941

  Fly   848 QLQKINVICPQRPDRVGLKSEVILETKRRAEQIKRAAAKPATAN-------KYTQAAVAPP---- 901
            ..:|...:....|  ..|.....| ::|..|.:...::..:.|.       :.|..:||.|
Mouse   942 AKRKTPPVRSTAP--ASLSRSAFL-SQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGE 1003

  Fly   902 -SPPDVAPTPAVAPMPQATVTVAPP------LPKPMPSIPSVVEKPGVPTHPTTPV----ATPFS 955
             :.|......||.|:|:....|..|      ||:.||     ..||.: .|.::|.    |...|
Mouse  1004 DAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMP-----FAKPHL-IHSSSPAVMSSAVSTS 1062

  Fly   956 FSQSIPFVKTSTVTPT----------TNTVTPGEAA------------KPGLSIFGGSTISSF-- 996
            .::.||....||:..|          ::||...:||            .|.:|....||:.:.
Mouse  1063 ATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQ 1127

  Fly   997 -----SFGGGAAKSALSFGTGSPAVAAPTPKPNPLSAVEKPTP-------------EPTKPKEQK 1043
                 ......:..:.:.|:.....||.||     .||..|..             :|:.|....
Mouse  1128 VVNVQELRSNPSPPSAAMGSAVQHSAAKTP-----HAVLTPVANSQAKQGSLINSFKPSGPTAAS 1187

  Fly  1044 AAESKEFKAVQPET--EESKVPQKPKAETE-NKSFGFGG-FTGTGGTVGNTSSS----------- 1093
            ...|...|||...|  .||.....|.|..: ||.|.|.. .|.|.||:..|.||
Mouse  1188 CQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPP 1252

  Fly  1094 --------PFSFGGLGSSLGFGGTAAAVPKSEPSSTATTSVATSASTAPFGIFSAALAKPSNSEP 1150
                    .|||||.|...     :.|:|.:.|::.||::.:||.:.|.....:.:.:||: :.|
Mouse  1253 TKEPTQLEAFSFGGGGKPF-----SEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPA-APP 1311

  Fly  1151 ITTVTSNT--------------------------------------------------------- 1158
            .|||:|.:
Mouse  1312 ETTVSSASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAK 1376

  Fly  1159 --------TTITSKPTNVIASSSVTDAPSVTTTNAVTSSTDPIGGLFSSVTICKPNTPADTTKPA 1215
                    |::..||.....:|||:.||:...:....|::.....:|.||.:.....|...:
Mouse  1377 PSGVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGLIS--- 1438

  Fly  1216 NIFGGGL---SAGSFSFGGTIDASK--------------------------GLF----GSTKPVA 1247
              |||..   |..|||||....:|.                          ||.    .|:.||:
Mouse  1439 --FGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVS 1501

  Fly  1248 T-------APTSVTEANNKTDPISTTPS------------------------------------- 1268
            :       ||.:|.:.::.::..:||||
Mouse  1502 SGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPAS 1566

  Fly  1269 ----AISTTTATTTVSSP-----------------------AVVPAAVTAAVPA----TSSTTVT 1302
                ..||.:...|:.:|                       ||:|.|.:||..|    |:||..:
Mouse  1567 SASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSS 1631

  Fly  1303 SS------TAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSPTATSTGNNSSNSVFGGGFA 1361
            ||      |||.|:|.|.|:.|:.    ..||.::||.:.|::.:.||.     |:..|||...|
Mouse  1632 SSPTSATETAVFGTATSGSSVFTQ----PPAASSSSAFSQLSSNTATAP-----SATPVFGQVAA 1687

  Fly  1362 VATSTAAPVASPFQSAAKSP---VSSANIFGSIPKAETSVFGGATTAPSN--------------- 1408
            ..|||||.......|...||   .|:..:||.....:|..||.||::|::
Mouse  1688 SITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAF 1752

  Fly  1409 -TTAAATPDAPPAGLF-ASAAISNPS--PFGSPTTRAPASGGNIFGQAVKPSVFGQPAQAGDSGG 1469
             .:.::||.:..|.:| |:::.|:|.  .||..:|.   :||.:|||. .|..|||....| .|.
Mouse  1753 GQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTN---TGGTLFGQN-NPPAFGQSPGFG-QGS 1812

  Fly  1470 SIFGGGSAST----PFGSS----SIFGGGNTQGAVGAPAAGSTSIFGQK-------VFGQSSAAA 1519
            |:|||.||:|    |.|.|    |.||..||....|..|....|:|||:       |||..:|
Mouse  1813 SVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQQSSTSSGGVFGSGNA-- 1875

  Fly  1520 PAAGGNIFSNPVGSP-----QASPF--GGGGNSIFGSPATAPPASGGSIFG--GGSSSGGFG--S 1573
             ..||..||...|.|     ..:||  .|||   |||.| ||..|  ::||  |..:.||||  |
Mouse  1876 -TRGGGFFSGLGGKPSQDAANKNPFSSAGGG---FGSTA-APNTS--NLFGNSGAKTFGGFGSSS 1933

  Fly  1574 FTQTTPAQGGFGGGFGQGGGGSVAQTGFGSPQAPQQQTTTP---GGFGAKPVFGGSPAFGASPTF 1635
            |.:..||      |....||||||..|||        .:||   |||||.||||..|.||.||.|
Mouse  1934 FGEQKPA------GTFSSGGGSVASQGFG--------FSTPNKTGGFGAAPVFGSPPTFGGSPGF 1984

  Fly  1636 GGGATFGSPKGF-------GG--FGGASPVASPPPFGAAAKPAQGNI--FETLGGQESGLSFGNL 1689
            ||...|||...|       ||  ||..:..||...||..   :.||.  |.||..|.:. :||:|
Mouse  1985 GGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFG---SSGNTASFGTLASQNAP-TFGSL 2045

  Fly  1690 AQT-----------------------GNSNAQKPAFGG 1704
            :|.                       |:||:....|||
Mouse  2046 SQQTSGFGTPSSGFAGFGSGTGAFTFGSSNSSVQGFGG 2083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201	61/215 (28%)
		WD40 repeat	38..86	CDD:293791	15/54 (28%)
		WD40 repeat	90..131	CDD:293791	11/46 (24%)
		WD40 repeat	139..173	CDD:293791	8/33 (24%)
Nup214	XP_006498008.1	WD40	<23..>266	CDD:225201	71/262 (27%)
		WD40 repeat	39..86	CDD:293791	15/53 (28%)
		WD40 repeat	96..144	CDD:293791	11/53 (21%)
		WD40 repeat	152..190	CDD:293791	8/37 (22%)
		ANAPC4_WD40	155..>216	CDD:372368	22/60 (37%)
		WD40 repeat	196..230	CDD:293791	14/34 (41%)
		WD40 repeat	243..291	CDD:293791	13/55 (24%)
		WD40 repeat	304..350	CDD:293791	13/45 (29%)
		PHA03247	<428..698	CDD:223021	87/351 (25%)
		Smc	689..>880	CDD:224117	47/222 (21%)
		PHA03247	<1016..1327	CDD:223021	109/525 (21%)
		PHA03247	<1204..1612	CDD:223021	161/569 (28%)
		NupH_GANP	1701..>1859	CDD:374788	3/7 (43%)
		COG5651	<1784..2074	CDD:227938
		Nup214_FG	1912..1973	CDD:376043

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	335	1.000	Domainoid score	I1122
eggNOG	1	0.900	-	-		E1_KOG3630
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2315
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46620
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006508
OrthoInspector	1	1.000	-	-		oto93317
orthoMCL	1	0.900	-	-		OOG6_106765
Panther	1	1.100	-	-	LDO	PTHR23193
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R851
SonicParanoid	1	1.000	-	-		X5483
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860