DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup214 and Nup214

DIOPT Version :10

Sequence 1:NP_652039.2 Gene:Nup214 / 46091 FlyBaseID:FBgn0010660 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_001395026.1 Gene:Nup214 / 227720 MGIID:1095411 Length:2086 Species:Mus musculus


Alignment Length:2183 Identity:561/2183 - (25%)
Similarity:849/2183 - (38%) Gaps:600/2183 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DTQDFQFKLHHKIVAFKKCGE-PRSNVNLLAVSSSRGLLFAGSPTQPELKVIIVKDLVNAKSTAQ 73
            :.:||||:...|:..|....| |:...::|.:|:..|:||||...  .|.|...|.|:.......
Mouse    13 EMKDFQFRALKKVRIFDSPEELPKERSSVLTISNKYGMLFAGGTN--GLNVFPTKSLLIQNKPGD 75

  Fly    74 QP-------QARLVPLPSIPNYIACSSDG-NLLAVNHTQNGTSLLSIYAVLSFMT---PDVRP-- 125
            .|       |...||:....:::|.|.|. .|.|...:....|:::.:.|.:|..   |..||  
Mouse    76 DPNKIVDTIQGLNVPMKFPVHHLALSCDSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFT 140

  Fly   126 VYNIRLAAEDHVHGVQLLWNPVLPNSLAVVLSNGALAMYALKEGGNFEMHSLDKNQQVKCGCWSP 190
            .:.:...|...|:.::  |||.:|:.:||.|::|::::..:.:.... ..:|..:..|.|.||||
Mouse   141 YHKVSNDASGMVNDMK--WNPTVPSMVAVCLADGSISVLQVTDVVKV-CATLPPSTGVTCVCWSP 202

  Fly   191 KGKQIVLGFPGGTVKQFKPDLTLAKTLLCPPNIH-DAPFDTIAIQWLSTFQFAVIFLQHGED--- 251
            ||||:.:|...|||.|:.|.|...|.:.|||... |.|...:.:.|:.|:.|.:::.  |.|   
Mouse   203 KGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFTIVYA--GADGTL 265

  Fly   252 --CSPSLYILNAPKAGAPS---YINYYDICYSMNGPRNHQFVFSHVPQWNLLLVVSANGVEVGIM 311
              | |.:.:...||.....   ::|:.:.|||....|.|.:..|::.:|:|:|..||...||.|:
Mouse   266 ETC-PDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSIL 329

  Fly   312 RSTEAGDTPAWQQLTLLDEARIEMPLSEDKDETFPLGFAFDTSTTHQLTINEKK-LQTMPMVHVL 375
              ....|...|:...|.|.:|.|:|:::..|::.|:|.|.|.:...::||||:| |...|::.:|
Mouse   330 --ARQNDQTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLL 392

  Fly   376 SSDGELLSFNFLNVLPTAVSVCSPPPPVADTSGQFKPL---------NMLLASEEEEQPAWAASP 431
            |:||.|..|..:|..|...|:......:: |.|:.:|.         :...|.:..:.||.|:||
Mouse   393 STDGVLCPFYMINQNPGVRSLIKTLELIS-TEGERQPKSSGSFPGTPSSPQAPQNLDAPATASSP 456

  Fly   432 ----SKAPAAT----PAASSDISFAFTPN------TVTSTPA--PSKDKQPSLFSGFGAAA-AKA 479
                |.||.:|    .||.|...|:|.|:      :||..|.  |:.........|.|.:. :.|
Mouse   457 LPPVSAAPTSTFPMPSAAGSPSVFSFGPSSFKSSASVTGEPPLYPTGSDSSRAAPGSGTSTFSFA 521

  Fly   480 PAPQLSFGTAPTSSPV-SFGAPTTNAAKPT---TPFGGFGTQATTTAMGSMFSASGANA------ 534
            |..:.|..:.|..:|| :..||.|...|||   ||.    :....|.|...|..|.::.      
Mouse   522 PPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPM----SSTPNTGMKPSFPPSASSVKVNLNE 582

  Fly   535 -FGGMALNKPAIASVTPRTAAPGSTVPATPASAPANKPL------YTVPLTFTPVDTKPATSAPP 592
             |..:|.:.|..:|.:..:..|.|:.|...||.|.:.|.      .::||. :.|...||.....
Mouse   583 KFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLK-SSVSPSPAAGRST 646

  Fly   593 QIADES-------------------------LKPDDTE---PIIKDM------IALQIEAFSKDI 623
            |.|..|                         |:|..||   |..||.      |..:|..|.|::
Mouse   647 QTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKEL 711

  Fly   624 QKQKEQTKELLKGIAAPSALRAYAKRLDDLQ----ELNEQAKDVEFELDVQGLRQGLNEAYAIVA 684
            ::.|.:|.:....:.....::......|||.    |:.|..:.:..  |:..|:..|.|.:|.|.
Mouse   712 EELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHG--DISTLKTTLLEGFAGVE 774

  Fly   685 ECR---------GKLE-IYRKPEITRLMNSSSCDPSGRRML---ARLQSYVAANEAQLRLAQQHV 736
            |.|         |.|. :|::|          .||.....|   .||..||       :.|.|.|
Mouse   775 EAREQHGRNHDSGYLHLLYKRP----------LDPKSEAQLQEIRRLHQYV-------KFAVQDV 822

  Fly   737 ----DLQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIVQNNIKSKLKERGL---- 793
                ||:|::..:..:|  :.|:.:|..|.::..|...:.:.:.||...|.:...|::..|    
Mouse   823 NDVLDLEWDRHLEQKKR--QRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHT 885

  Fly   794 ----LQAALLDQEKSRTRTNEAVDTLTDSILTMSLSQVVDSNA-------AKLTRERLQKIRNIV 847
                |.:||..|..|.:         .||.|...|...::|:.       .||:..:..::||.:
Mouse   886 APWSLPSALSTQSNSHS---------FDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFL 941

  Fly   848 QLQKINVICPQRPDRVGLKSEVILETKRRAEQIKRAAAKPATAN-------KYTQAAVAPP---- 901
            ..:|...:....|  ..|.....| ::|..|.:...::..:.|.       :.|..:||.|    
Mouse   942 AKRKTPPVRSTAP--ASLSRSAFL-SQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGE 1003

  Fly   902 -SPPDVAPTPAVAPMPQATVTVAPP------LPKPMPSIPSVVEKPGVPTHPTTPV----ATPFS 955
             :.|......||.|:|:....|..|      ||:.||     ..||.: .|.::|.    |...|
Mouse  1004 DAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMP-----FAKPHL-IHSSSPAVMSSAVSTS 1062

  Fly   956 FSQSIPFVKTSTVTPT----------TNTVTPGEAA------------KPGLSIFGGSTISSF-- 996
            .::.||....||:..|          ::||...:||            .|.:|....||:.:.  
Mouse  1063 ATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQ 1127

  Fly   997 -----SFGGGAAKSALSFGTGSPAVAAPTPKPNPLSAVEKPTP-------------EPTKPKEQK 1043
                 ......:..:.:.|:.....||.||     .||..|..             :|:.|....
Mouse  1128 VVNVQELRSNPSPPSAAMGSAVQHSAAKTP-----HAVLTPVANSQAKQGSLINSFKPSGPTAAS 1187

  Fly  1044 AAESKEFKAVQPET--EESKVPQKPKAETE-NKSFGFGG-FTGTGGTVGNTSSS----------- 1093
            ...|...|||...|  .||.....|.|..: ||.|.|.. .|.|.||:..|.||           
Mouse  1188 CQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPP 1252

  Fly  1094 --------PFSFGGLGSSLGFGGTAAAVPKSEPSSTATTSVATSASTAPFGIFSAALAKPSNSEP 1150
                    .|||||.|...     :.|:|.:.|::.||::.:||.:.|.....:.:.:||: :.|
Mouse  1253 TKEPTQLEAFSFGGGGKPF-----SEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPA-APP 1311

  Fly  1151 ITTVTSNT--------------------------------------------------------- 1158
            .|||:|.:                                                         
Mouse  1312 ETTVSSASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAK 1376

  Fly  1159 --------TTITSKPTNVIASSSVTDAPSVTTTNAVTSSTDPIGGLFSSVTICKPNTPADTTKPA 1215
                    |::..||.....:|||:.||:...:....|::.....:|.||.:.....|...:   
Mouse  1377 PSGVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGLIS--- 1438

  Fly  1216 NIFGGGL---SAGSFSFGGTIDASK--------------------------GLF----GSTKPVA 1247
              |||..   |..|||||....:|.                          ||.    .|:.||:
Mouse  1439 --FGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVS 1501

  Fly  1248 T-------APTSVTEANNKTDPISTTPS------------------------------------- 1268
            :       ||.:|.:.::.::..:||||                                     
Mouse  1502 SGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPAS 1566

  Fly  1269 ----AISTTTATTTVSSP-----------------------AVVPAAVTAAVPA----TSSTTVT 1302
                ..||.:...|:.:|                       ||:|.|.:||..|    |:||..:
Mouse  1567 SASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSS 1631

  Fly  1303 SS------TAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSPTATSTGNNSSNSVFGGGFA 1361
            ||      |||.|:|.|.|:.|:.    ..||.::||.:.|::.:.||.     |:..|||...|
Mouse  1632 SSPTSATETAVFGTATSGSSVFTQ----PPAASSSSAFSQLSSNTATAP-----SATPVFGQVAA 1687

  Fly  1362 VATSTAAPVASPFQSAAKSP---VSSANIFGSIPKAETSVFGGATTAPSN--------------- 1408
            ..|||||.......|...||   .|:..:||.....:|..||.||::|::               
Mouse  1688 SITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAF 1752

  Fly  1409 -TTAAATPDAPPAGLF-ASAAISNPS--PFGSPTTRAPASGGNIFGQAVKPSVFGQPAQAGDSGG 1469
             .:.::||.:..|.:| |:::.|:|.  .||..:|.   :||.:|||. .|..|||....| .|.
Mouse  1753 GQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTN---TGGTLFGQN-NPPAFGQSPGFG-QGS 1812

  Fly  1470 SIFGGGSAST----PFGSS----SIFGGGNTQGAVGAPAAGSTSIFGQK-------VFGQSSAAA 1519
            |:|||.||:|    |.|.|    |.||..||....|..|....|:|||:       |||..:|  
Mouse  1813 SVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQQSSTSSGGVFGSGNA-- 1875

  Fly  1520 PAAGGNIFSNPVGSP-----QASPF--GGGGNSIFGSPATAPPASGGSIFG--GGSSSGGFG--S 1573
             ..||..||...|.|     ..:||  .|||   |||.| ||..|  ::||  |..:.||||  |
Mouse  1876 -TRGGGFFSGLGGKPSQDAANKNPFSSAGGG---FGSTA-APNTS--NLFGNSGAKTFGGFGSSS 1933

  Fly  1574 FTQTTPAQGGFGGGFGQGGGGSVAQTGFGSPQAPQQQTTTP---GGFGAKPVFGGSPAFGASPTF 1635
            |.:..||      |....||||||..|||        .:||   |||||.||||..|.||.||.|
Mouse  1934 FGEQKPA------GTFSSGGGSVASQGFG--------FSTPNKTGGFGAAPVFGSPPTFGGSPGF 1984

  Fly  1636 GGGATFGSPKGF-------GG--FGGASPVASPPPFGAAAKPAQGNI--FETLGGQESGLSFGNL 1689
            ||...|||...|       ||  ||..:..||...||..   :.||.  |.||..|.:. :||:|
Mouse  1985 GGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFG---SSGNTASFGTLASQNAP-TFGSL 2045

  Fly  1690 AQT-----------------------GNSNAQKPAFGG 1704
            :|.                       |:||:....|||
Mouse  2046 SQQTSGFGTPSSGFAGFGSGTGAFTFGSSNSSVQGFGG 2083

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup214NP_652039.2 Nucleoporin_FG 485..>537 CDD:463941 17/62 (27%)
YhaN <604..>806 CDD:443752 56/239 (23%)
PRK10263 <885..>1149 CDD:236669 81/350 (23%)
COG4625 1219..>1696 CDD:443664 201/675 (30%)
Nup214NP_001395026.1 WD40 repeat 39..86 CDD:293791 15/53 (28%)
Seven-bladed beta propeller. /evidence=ECO:0000250 41..404 112/385 (29%)
WD40 <94..>265 CDD:441893 51/182 (28%)
WD40 repeat 96..144 CDD:293791 11/53 (21%)
WD40 repeat 152..190 CDD:293791 8/37 (22%)
ANAPC4_WD40 155..>216 CDD:403945 22/60 (37%)
WD40 repeat 196..230 CDD:293791 14/34 (41%)
46 X 2 AA repeats of F-G. /evidence=ECO:0000250|UniProtKB:P35658 236..1430 366/1601 (23%)
WD40 repeat 243..291 CDD:293791 13/55 (24%)
WD40 repeat 304..350 CDD:293791 13/45 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..469 19/61 (31%)
PHA03247 <428..698 CDD:223021 87/351 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..531 13/43 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..574 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..694 32/152 (21%)
Leucine-zipper 1 734..762 8/31 (26%)
Leucine-zipper 2 855..876 3/20 (15%)
PHA03247 <1016..1327 CDD:223021 109/525 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1134..1154 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1328 56/267 (21%)
Nucleoporin_FG2 1182..>1367 CDD:435043 63/298 (21%)
PHA03247 <1204..1612 CDD:223021 161/569 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1384 11/32 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1453..1474 8/20 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1495..1575 34/95 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1615..1636 14/23 (61%)
PPE <1645..1869 CDD:444372 27/97 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1763..1814
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1881..1900
Nup214_FG 1913..1973 CDD:408399
46. /evidence=ECO:0000305 2081..2082

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