DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup214 and npp-4

DIOPT Version :9

Sequence 1:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_493552.1	Gene:	npp-4 / 173329	WormBaseID:	WBGene00003790	Length:	538	Species:	Caenorhabditis elegans

Alignment Length:	287	Identity:	96/287 - (33%)
Similarity:	122/287 - (42%)	Gaps:	98/287 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1397 SVFGGATTAPSNTTAAATPDAPPAGLFASAAISNPSP---FGSPTTRAPASGGNIFGQA-VKPSV 1457
            |:||.:||||:   |:.||      ||.|.|.:.|.|   ||:|   |.|....:||.: ..|:
Worm     2 SLFGTSTTAPA---ASTTP------LFGSTAAAAPKPGGLFGAP---AAAMSSGLFGASQTAPA- 53

  Fly  1458 FGQPAQAGDSGGSIFGGGSASTPFGSSSI--FGGGNTQGAVGAPAAGSTSIFGQKVFGQSSAAAP 1520
               ||.||     :||..:|.||..:||:  ||...|   ..:|:.|   :||.|.   ::.|||
Worm    54 ---PASAG-----LFGSTTAPTPASTSSVPLFGSTTT---TASPSGG---LFGAKT---ATTAAP 101

  Fly  1521 AAGGNIFSNPVGSPQASPFGGGGNSIFGSPATAPPASGGSIFGGGSSSGGFGSFTQTTPAQGGFG 1585
            |..|.:|    |:..|:|..|   |:|||.|   ||:|| :||..|          ||.|....|
Worm   102 APTGGLF----GASTAAPATG---SLFGSTA---PATGG-LFGAKS----------TTSAAPTLG 145

  Fly  1586 GGFGQGGGGSVAQTGFGSPQAPQQQTTTPGGFGAKPVFGGSPAFGASPTFGGGATFGSPKGFGGF 1650
            ||.            |||..||....||              :|||.|     ||..:|.|.||.
Worm   146 GGL------------FGSSTAPAAAATT--------------SFGAPP-----ATAAAPLGLGGI 179

  Fly  1651 ------GGASPVASPPPFGAAAKPAQG 1671
                  ||..|.||    |.|.....|
Worm   180 QQQNSSGGGLPNAS----GTATSSLTG 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201
		WD40 repeat	38..86	CDD:293791
		WD40 repeat	90..131	CDD:293791
		WD40 repeat	139..173	CDD:293791
npp-4	NP_493552.1	Nucleoporin_FG	21..122	CDD:290362	42/128 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910