DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup214 and AgaP_AGAP002351

DIOPT Version :9

Sequence 1:	NP_652039.2	Gene:	Nup214 / 46091	FlyBaseID:	FBgn0010660	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_312609.5	Gene:	AgaP_AGAP002351 / 1273613	VectorBaseID:	AGAP002351	Length:	2063	Species:	Anopheles gambiae

Alignment Length:	906	Identity:	235/906 - (25%)
Similarity:	309/906 - (34%)	Gaps:	295/906 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   939 KPGVPTHPT-----------TPVATPFSFSQSIPFVKTSTVTPTTNT--VTPGEAAKPGLSIFGG 990
            |||....||           |..|:|  |.|:..|.|     |.|..  .||....:|..|:||.
Mosquito     5 KPGGFGQPTTNTGFGTFGTNTAAASP--FGQTTAFSK-----PATGAFGATPAFGQQPTTSLFGQ 62

  Fly   991 STISSFSFGGGAAKSALSFGTGSPAVAAPTPKPNPLSAVEKPTPEPTKPKEQKAAESKEFKAVQP 1055
            :..:...||...:.        :||..|.|.:|.                      ...|...||
Mosquito    63 TQQTGGLFGASTST--------APAFGAATTQPG----------------------FGAFGQAQP 97

  Fly  1056 ETEESKVPQKPKAETENKSFGFGGFTGTGGTVGNTSSSPFSFG-------GLGSSLGFGG----- 1108
            :|                       |...||..||:::...||       |.....||||
Mosquito    98 QT-----------------------TSLFGTQNNTAANTSLFGNNNNTTFGAAKPAGFGGFGQPA 139

  Fly  1109 --TAAAVPKSEPSSTATTSVATSASTAPFGIFSAALAKPS-NSEPITTVTSNTTTITSKPTNVIA 1170
              |.:...:|..::||||......:....|:|.|  |||: .:..:..|.....|..:|......
Mosquito   140 TQTTSLFGQSTTNNTATTGFFGQNTQTAGGLFGA--AKPAFGAATVPGVVGGNGTAVAKYQQTHG 202

  Fly  1171 SSSVTDAPSVTTTN----AVTSSTDPIGGLFSSVTICKPNTPADTTKPANIFGGGLSAGSFSFGG 1231
            :.::......||.|    .:|...|...   .||...:....|...|       |..||:...||
Mosquito   203 TDTLVKNGQTTTVNTKQHCITFMKDYEN---KSVEELRFEDYAANRK-------GPQAGAPGAGG 257

  Fly  1232 TIDA---SKGLFGSTKPVATAPTSVTEANNKTDPISTTPSAISTTT--ATTTVSSPAV-VPAAVT 1290
            ...|   |.||||.|.  ||..|.:. ..|:..|.:......||.|  ||||   ||. ..|..|
Mosquito   258 LFGAGTQSTGLFGGTG--ATQTTGLF-GQNQAQPAAGGLFGTSTNTFGATTT---PAFGTTAGST 316

  Fly  1291 AAVPATSSTTVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSPTATSTGNNSSNSV 1355
            ...|..|:...||:     |.|.|:.:.::...||           |.|..|...:||  ::..:
Mosquito   317 FGKPFGSTPAATSA-----SGFGFAQSTTSTLGGG-----------LGANKPAFGATG--TTGGL 363

  Fly  1356 FGGGFAVATSTAAPVASPFQSAAKSPVSSANIFGSIPKAETSVFGGATTAPSNTT---------A 1411
            ||       .||.|              :.|.||..|      |||..|  .|||         |
Mosquito   364 FG-------QTAVP--------------ATNTFGQTP------FGGFGT--QNTTAQQGGLFSGA 399

  Fly  1412 AATPDAPPAGLFAS-AAISNPSPFGSPT-TRAPASGGNIFGQAVKPSVFGQPAQA-GDSGGSIFG 1473
            .|...||.||.|.: .|.|.||.|...| |:..|:|..:||        .:||.. |..||:.||
Mosquito   400 GAGTAAPAAGAFGTLGAQSTPSSFSFGTNTQTSAAGSTLFG--------AKPANTFGTLGGTTFG 456

  Fly  1474 GGSASTPFGSSSIFG-GGNTQGAVGAPAAGSTSIFGQKVFGQSSAAA------PAAGGNIFSNPV 1531
            ..:.|    |::.|| |.||..|.|      .|.|| ..|.:.:|..      .||||.|    .
Mosquito   457 QSATS----SAATFGLGTNTNAAAG------NSFFG-NTFNKPAATTFGLGTNTAAGGGI----G 506

  Fly  1532 GSPQASPFGGGGNSIFGSPATAPP--ASGGSIFGGGS---SSGGFGSFTQTTPAQGGFG-GGFGQ 1590
            |:.....||.|.:|:||:.|..|.  .:|.|:||..|   :.|.||:....|....|.| ||.|.
Mosquito   507 GTTGGLTFGTGTSSLFGNTAAKPGGLGTGTSLFGNTSTLGTGGAFGTMNMGTSFGAGTGTGGLGM 571

  Fly  1591 ---GGGGSVAQTGFGSPQAPQQQ-----TTTPGGFGAKPVFGG-SPAFGAS-----PTFGGGATF 1641
               ||.||:||...|....|..|     .|:|  :|..|:|.| .|..|.|     ||
Mosquito   572 STLGGLGSMAQGAAGQQAVPIHQQILAMATSP--YGDNPIFKGIKPLAGPSEDSLKPT------- 627

  Fly  1642 GSPKG-------------FGGFGGASPVASPPPFGAAAKPAQGNIFETL---------------- 1677
             :|..             .....|::......|.|||  ..:.:|||.|
Mosquito   628 -NPSAQKAILEGSNYQLKISSRSGSTDRVKVKPLGAA--QLKKSIFEGLEEYDSTLEDSFTLKPN 689

  Fly  1678 -----------------------GGQESG---LSFGNLAQTGNSNAQKP---AFGGSSFMN 1709
                                   ||:|.|   ||..:....|...|..|   :..|.||.|
Mosquito   690 AKRLIIKPRTSKSMIIIPESGGGGGREGGQYNLSGASNTSIGGDAAPTPTRLSGAGESFRN 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup214	NP_652039.2	WD40	<31..>233	CDD:225201
		WD40 repeat	38..86	CDD:293791
		WD40 repeat	90..131	CDD:293791
		WD40 repeat	139..173	CDD:293791
AgaP_AGAP002351	XP_312609.5	Nucleoporin_FG	1..71	CDD:290362	20/72 (28%)
		Nucleoporin_FG	47..172	CDD:290362	36/177 (20%)
		Nucleoporin_FG	<247..323	CDD:290362	29/81 (36%)
		Nucleoporin_FG	296..396	CDD:290362	41/149 (28%)
		Nucleoporin_FG	415..501	CDD:290362	32/104 (31%)
		Nucleoporin2	917..1057	CDD:282016
		Nup96	1589..1885	CDD:288926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910