Protein Alignment MYC and myc

DIOPT Version :9

• Sequence 1: NP_002458.2
• Gene: MYC / 4609
• HGNCID: 7553
• Length: 454
• Species: Homo sapiens
• Sequence 2: NP_989390.1
• Gene: myc / 395024
• XenbaseID: XB-GENE-6052814
• Length: 418
• Species: Xenopus tropicalis
• Alignment Length: 469
• Identity: 281/469 - (59%)
• Similarity: 326/469 - (69%)
• Gaps: 87/469 - (18%)

Human    16 MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSR 80
            ||||.:|.::|||.||| :||.|:..||||||  .|||.||||||||||||||||||||||||||
 Frog     1 MPLNANFPSKNYDYDYD-LQPCFFFLEEENFY--HQQSRLQPPAPSEDIWKKFELLPTPPLSPSR 62

Human    81 RSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIII 145
            ||     |..::.|              |||||||||||.||||||||||||:.|||..:|:|:|
 Frog    63 RS-----SQSSLFP--------------STADQLEMVTEFLGGDMVNQSFICEADDEALLKSIVI 108

Human   146 QDCMWSGFSAAAKL---VSEKLASYQAARKDSG-------SP---NPARGHSVCSTSSL------ 191
            ||||||||||||||   ||||||||||:||:|.       ||   :|.:..|...:.||
 Frog   109 QDCMWSGFSAAAKLEKVVSEKLASYQASRKESALSSSQCQSPPEQSPLKSPSCHGSLSLGGTRSS 173

Human   192 --YLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLV 254
              :|||.|   |:|:|||||||||||||.         |:|.||..|.:|
 Frog   174 HGFLQDPS---SDCVDPSVVFPYPLNDSI---------SNASSPCQDLML--------------- 211

Human   255 LHEETPP----TTSSDSEEEQED-------EEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHS 308
               ||||    ::||:||||.||       |||||||:|||||...||.||.|.|.  .|:|.||
 Frog   212 ---ETPPISSNSSSSESEEEPEDEDEDCDEEEEIDVVTVEKRQTASKRMESSSHSQ--PSRPHHS 271

Human   309 PLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDS-VRVLRQISNNRKCTSPRSSDTEENVKRR 372
            |||||||||..|||||||.|||:.||.::||.||:| .|||:||||||||:||||||:|||.|||
 Frog   272 PLVLKRCHVPIHQHNYAASPSTKVDYVSSKRAKLESNARVLKQISNNRKCSSPRSSDSEENDKRR 336

Human   373 THNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRK 437
            ||||||||||||||.||||||||:||:.|||||||||||||||.|::|:|.:|::||.|.:.|:.
 Frog   337 THNVLERQRRNELKLSFFALRDQVPEVANNEKAPKVVILKKATEYVVSMQEDERRLIRETEQLKY 401

Human   438 RREQLKHKLEQLRN 451
            ||||||.:|:||||
 Frog   402 RREQLKQRLQQLRN 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYC	NP_002458.2	Myc_N	21..360	CDD:279405	207/371 (56%)
		HLH	370..426	CDD:238036	45/55 (82%)
		Myc-LZ	423..453	CDD:280500	16/29 (55%)
myc	NP_989390.1	Myc_N	6..324	CDD:366440	207/371 (56%)
		bHLHzip_c-Myc	330..413	CDD:381464	60/82 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I7580
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31092
Inparanoid	1	1.050	478	1.000	Inparanoid score	I7973
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50300
OrthoDB	1	1.010	-	-		D221552at32523
OrthoFinder	1	1.000	-	-		FOG0006386
OrthoInspector	1	1.000	-	-		oto154895
Panther	1	1.100	-	-	LDO	PTHR45851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4673
SonicParanoid	1	1.000	-	-		X7143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110