DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYC and mycb

DIOPT Version :9

Sequence 1:	NP_002458.2	Gene:	MYC / 4609	HGNCID:	7553	Length:	454	Species:	Homo sapiens
Sequence 2:	NP_956466.1	Gene:	mycb / 393141	ZFINID:	ZDB-GENE-040426-780	Length:	396	Species:	Danio rerio

Alignment Length:	456	Identity:	252/456 - (55%)
Similarity:	307/456 - (67%)	Gaps:	77/456 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    16 MPLNVSFTNRNYDLDYDSVQPYFYCD-EEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPS 79
            ||||.|...:|||.||||.|||||.| |:|:||..|..   ||||||||||||||||||||||||
Zfish     1 MPLNSSMECKNYDYDYDSYQPYFYFDNEDEDFYNHQHG---QPPAPSEDIWKKFELLPTPPLSPS 62

Human    80 RRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD-DETFIKNI 143
            ||..|..       ||.            ||||:||||:|.||.|:||.|.|||.| .::|:|:|
Zfish    63 RRPSLSD-------PFP------------STADKLEMVSEFLGDDVVNHSIICDADYSQSFLKSI 108

Human   144 IIQDCMWSGFSAAAKL---VSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECID 205
            ||||||||||||||||   |||:|||.|||||:|.....|   .:|.:.. :|||:|..||:|||
Zfish   109 IIQDCMWSGFSAAAKLEKVVSERLASLQAARKESSRTESA---DICRSVG-FLQDMSTPASQCID 169

Human   206 PSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPP-----TTSS 265
            ||||||:||.||:.|  |                     .|..:|....|..:|||     ::||
Zfish   170 PSVVFPFPLTDSTKP--C---------------------KPAPTPASTTLPLDTPPNSGSSSSSS 211

Human   266 DSE------EEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNY 324
            |||      |::|:|||||||:||||::. |:|::.:..        .||:|||||||:.|||||
Zfish   212 DSESDDEDDEDEEEEEEIDVVTVEKRKSV-KKSDANATH--------QSPVVLKRCHVNIHQHNY 267

Human   325 AAPPSTRKDYPAAKRVKLDS-VRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRS 388
            ||.||||.:.||.||:|.:| :||.:|||:||||.|||:||:|:|.|||||||||||||||||.|
Zfish   268 AAHPSTRNEQPAVKRIKFESHIRVFKQISHNRKCASPRTSDSEDNDKRRTHNVLERQRRNELKLS 332

Human   389 FFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSC 453
            ||||||.||::.|||||.|||||||||..|.|:|.:||:|||.::.||::.|.||.:||||  ||
Zfish   333 FFALRDVIPDVANNEKAAKVVILKKATECIASMQEDEQRLISLKEQLRRKCEHLKQRLEQL--SC 395

Human   454 A 454
            :
Zfish   396 S 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYC	NP_002458.2	Myc_N	21..360	CDD:279405	182/355 (51%)
		HLH	370..426	CDD:238036	43/55 (78%)
		Myc-LZ	423..453	CDD:280500	14/29 (48%)
mycb	NP_956466.1	Myc_N	6..304	CDD:279405	182/355 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..251		28/99 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..318		14/19 (74%)
		HLH	311..370	CDD:238036	44/58 (76%)
		Myc-LZ	368..396	CDD:280500	15/29 (52%)
		Leucine-zipper	372..393		10/20 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332934
Domainoid	1	1.000	310	1.000	Domainoid score	I7149
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31092
Inparanoid	1	1.050	426	1.000	Inparanoid score	I7525
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50300
OrthoDB	1	1.010	-	-		D280205at7742
OrthoFinder	1	1.000	-	-		FOG0006386
OrthoInspector	1	1.000	-	-		otm28413
orthoMCL	1	0.900	-	-		OOG6_115159
Panther	1	1.100	-	-	O	PTHR45851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4673
SonicParanoid	1	1.000	-	-		X7143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.440