DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYC and esc1

DIOPT Version :9

Sequence 1:	NP_002458.2	Gene:	MYC / 4609	HGNCID:	7553	Length:	454	Species:	Homo sapiens
Sequence 2:	NP_593230.1	Gene:	esc1 / 2543286	PomBaseID:	SPAC56F8.16	Length:	413	Species:	Schizosaccharomyces pombe

Alignment Length:	465	Identity:	103/465 - (22%)
Similarity:	170/465 - (36%)	Gaps:	109/465 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    11 QPPATMPLN-----------VSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDI 64
            ||..:.|.|           |..|:.:|.|...|           :|  |..|:.|.|.....:.
pombe    24 QPTTSAPSNSASSTPYSPQQVPLTHNSYPLSTPS-----------SF--QHGQTRLPPINCLAEP 75

Human    65 WKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQS 129
            :.:    |.|..|.|......||:...::               :.|..:......:.|...:..
pombe    76 FNR----PQPWHSNSAAPASSSPTSATLS---------------TAAHPVHTNAAQVAGSSSSYV 121

Human   130 FICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQA-----ARKDSGSPNPARGHSVCSTS 189
            :...|.:.|           .|..||....|..:.:.:|:     :..||.|.:.:...||.:::
pombe   122 YSVPPTNST-----------TSQASAKHSAVPHRSSQFQSTTLTPSTTDSSSTDVSSSDSVSTSA 175

Human   190 SLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDS-SAFSPSSDSLLSSTESSPQGSPEPL 253
            |      |:.||..:  ||..|    .|||.....:|.| ..|..|.:...::...|...:|...
pombe   176 S------SSNASNTV--SVTSP----ASSSATPLPNQPSQQQFLVSKNDAFTTFVHSVHNTPMQQ 228

Human   254 VLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSES-GSPSAGGHSKPPH-------SPL 310
            .::.....|:.|.....|.:.....|      |:|.:.|.| |.|    .|.|.|       ||:
pombe   229 SMYVPQQQTSHSSGASYQNESANPPV------QSPMQYSYSQGQP----FSYPQHKNQSFSASPI 283

Human   311 VLKRCHVSTHQHNYAAP---PSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRR 372
            .....:|      |.||   .|...:.|..:...|.  ||...:.|..:.|.|.:.:.|   .|.
pombe   284 DPSMSYV------YRAPESFSSINANVPYGRNEYLR--RVTSLVPNQPEYTGPYTRNPE---LRT 337

Human   373 THNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAE----EQKLISEED 433
            :|.:.||:||.|:|..|..|:|.:| |:.:.|:.|..:|.:|..||..:::|    |..:.|.|:
pombe   338 SHKLAERKRRKEIKELFDDLKDALP-LDKSTKSSKWGLLTRAIQYIEQLKSEQVALEAYVKSLEE 401

Human   434 LLRKRREQLK 443
            .::..:|..|
pombe   402 NMQSNKEVTK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYC	NP_002458.2	Myc_N	21..360	CDD:279405	71/355 (20%)
		HLH	370..426	CDD:238036	20/59 (34%)
		Myc-LZ	423..453	CDD:280500	6/25 (24%)
esc1	NP_593230.1	HLH	336..386	CDD:278439	19/50 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	42	1.000	Domainoid score	I4135
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I2288
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050