DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and SLC17A1

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_016866688.1	Gene:	SLC17A1 / 6568	HGNCID:	10929	Length:	517	Species:	Homo sapiens

Alignment Length:	465	Identity:	129/465 - (27%)
Similarity:	223/465 - (47%)	Gaps:	30/465 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FFGVRHVQCILCFFCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFNSERYY 83
            |...|:....|...|..:..|.|..|::.:|.|.:::......||:|     :...|...:. .|
Human    65 FCSFRYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTST-----KKLLDNIKNP-MY 123

  Fly    84 NFTQKEKGNLQASFFFGYIVTQVPGGYIAQRYGAKTMLMYGLGIAALITMLSPMSLQFGWVALAV 148
            |::...:|.:.:|..:|.|:.|||.||.:..|..|.|:.:.|.:::::::|.|.:...|...:.|
Human   124 NWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVV 188

  Fly   149 MRFVMGLAQGAVHPATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVLGWPSIF 213
            .|.|.|.|||.|..|...:..||:|..|||.|.::..||...|..::|..:|.|.:| ||||.:|
Human   189 CRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICES-LGWPMVF 252

  Fly   214 YLGGACGFIWMVFWYLFSASTPEEHRLISPGELKYITDSRSDGKMQSAEKLAPTPWKAIFSSLPF 278
            |:.||||....:.|::.....|::|..||..|.:|||.|.......|.:.|   |.|||..|||.
Human   253 YIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITSSLVQQVSSSRQSL---PIKAILKSLPV 314

  Fly   279 LSLLVVHCTHIFGYWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVW--------L 335
            .::.....|..:.:.::.:..|.::..:.||:||:...||||||:        |.|        |
Human   315 WAISTGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYL--------FAWICGNLAGQL 371

  Fly   336 SKVLQKKEGMSLSFNRKIFNSIGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYL-GFQ 399
            |.....:..:|:...||:|.:.|..:|.:..:.|.|:  .:...::.:..:..|.:|:..| |..
Human   372 SDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPYL--SSTFYSIVIFLILAGATGSFCLGGVF 434

  Fly   400 VNHIDLSPNYAGTLMGITNCAANVMSGIAPVIVGQIVVDETSVTEWRLVFLLAAAFYFLGNLLFV 464
            :|.:|::|.|.|.:...:.....:...||..:.| :::.:...:.|...|:|.||....|.:.::
Human   435 INGLDIAPRYFGFIKACSTLTGMIGGLIASTLTG-LILKQDPESAWFKTFILMAAINVTGLIFYL 498

  Fly   465 IFGRTEVQWW 474
            |....|:|.|
Human   499 IVATAEIQDW 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	129/465 (28%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	112/393 (28%)
SLC17A1	XP_016866688.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740