DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and SLC17A6

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_065079.1	Gene:	SLC17A6 / 57084	HGNCID:	16703	Length:	582	Species:	Homo sapiens

Alignment Length:	468	Identity:	148/468 - (31%)
Similarity:	252/468 - (53%)	Gaps:	22/468 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FGV--RHVQCILCFFCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFNSERY 82
            ||:  |::..|:......:|:..|.||.||:|.|.:|||             ...|......:..
Human    65 FGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNST-------------IHRGGKVIKEKAK 116

  Fly    83 YNFTQKEKGNLQASFFFGYIVTQVPGGYIAQRYGAKTMLMYGLGIAALITMLSPMSLQFGWVALA 147
            :|:..:..|.:..|||:|||:||:||||||.|..|..:....:.:.:.:.||.|.:.:..:..:.
Human   117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVI 181

  Fly   148 VMRFVMGLAQGAVHPATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVLGWPSI 212
            .:|.:.||.:|..:||.|.:.:||:|..||..|.|..:.|:..|.|:.:..:|.:. ...||.|:
Human   182 FVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILV-QYTGWSSV 245

  Fly   213 FYLGGACGFIWMVFWYLFSASTPEEHRLISPGELKYITDS--RSDGKMQSAEKLAPTPWKAIFSS 275
            ||:.|:.|.:|.:||.|.|..:|.:|..|:..|.:||.:|  .|...:.:.||. .|||:..|:|
Human   246 FYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKF-KTPWRKFFTS 309

  Fly   276 LPFLSLLVVHCTHIFGYWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVWLSKVLQ 340
            :|..:::|.:....:.::|||:..|.|.::::..:|.|..:||::|::||.::......::..|:
Human   310 MPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLR 374

  Fly   341 KKEGMSLSFNRKIFNSIGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQVNHIDL 405
            .|:.:|.:..|||.|..|..:....|:.:||  :....:|::.|.|.||.||....||.|||:|:
Human   375 SKQILSTTTVRKIMNCGGFGMEATLLLVVGY--SHTRGVAISFLVLAVGFSGFAISGFNVNHLDI 437

  Fly   406 SPNYAGTLMGITNCAANVMSGIAPVIVGQIVVDETSVTEWRLVFLLAAAFYFLGNLLFVIFGRTE 470
            :|.||..||||:|....:...:.|:|||.:..:: |..||:.|||:||..::.|.:.:.||...|
Human   438 APRYASILMGISNGVGTLSGMVCPIIVGAMTKNK-SREEWQYVFLIAALVHYGGVIFYAIFASGE 501

  Fly   471 VQWWDSPRDNKED 483
            .|.|..|.:..|:
Human   502 KQPWADPEETSEE 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	146/460 (32%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	125/386 (32%)
SLC17A6	NP_065079.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	139/441 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820