DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS14 and CG2003

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_651903.2	Gene:	CG2003 / 43761	FlyBaseID:	FBgn0039886	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	164/473 - (34%)
Similarity:	270/473 - (57%)	Gaps:	35/473 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GVRHVQCILCFFCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFNSERYYNF 85
            |:||:|..|.|:.||.:...::|:|||:||||:.:||   ||       |:|        .:||:
  Fly    15 GLRHLQAGLLFYGLAANTVLQLNVSVAVVAMTNETTS---NN-------SDP--------PHYNW 61

  Fly    86 TQKEKGNLQASFFFGYIVTQVPGGYIAQRYGAKTMLMYGLGIAALITMLSPMSLQF-GWVALAVM 149
            ::::|..:.:|:::|..:.|.|.||:.:|:|:|.:|.:|...::|::.|:...:.. ||.|...:
  Fly    62 SEEKKSYILSSYYWGCALAQFPAGYLCKRFGSKAVLFWGTLGSSLLSALTTYGVYAGGWKAYCAI 126

  Fly   150 RFVMGLAQGAVHPATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVLGWPSIFY 214
            |.:.||.| ...|..|..||.|.|..||..||...|:|...|.|:.:..:|.||.|.||||.|.|
  Fly   127 RLLQGLCQ-VTWPCIHQHLANWCPTAERTRLGAFAYTGFDCGNVLAMYGAGMIASSSLGWPGISY 190

  Fly   215 LGGACGFIWMVFWYLFSASTPEEHRLISPGELKYITDSRSDGKMQSAEKLAP----TPWKAIFSS 275
            .....|.||...|.|..|:...:.|.|...|..||.     |.:|.:|:..|    .|||.||:|
  Fly   191 SAAGLGLIWCGLWLLLGANKASDARFIGEAEKAYIV-----GDIQRSERKGPKKMEIPWKGIFTS 250

  Fly   276 LPFLSLLVVHCTHIFGYWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVWLSKVLQ 340
            :|..:||...|...:|...:..::|||:..:..:|:|..|:.|:||:::|.::.:.::.::.||.
  Fly   251 VPVYALLCARCADSWGLTTMQTELPTYLSGVLKLDMKSNAVFSALPFLLMWVMCYVYLIIADVLL 315

  Fly   341 KKEGMSLSFNRKIFNSIGHWIP---MLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQVNH 402
            :|:.|||:..||.:.||..|.|   ||||:.:|   .....|.:.|:||:||:|.|..:|.::|.
  Fly   316 RKKWMSLTTLRKTYTSIALWAPASIMLSLVIVG---EGQKTLVLVLVTLSVGVSSAATIGSELNT 377

  Fly   403 IDLSPNYAGTLMGITNCAANVMSGIAPVIVGQIVVDETSVTEWRLVFLLAAAFYFLGNLLFVIFG 467
            ||||||:||.|.|:.:...|:|:.:.|::||.:|.|.:..::|::||.|||...|.||::|:|:|
  Fly   378 IDLSPNHAGILAGLMSSFTNLMALLTPLVVGVLVTDPSQRSQWQIVFSLAAGVLFTGNVIFLIWG 442

  Fly   468 RTEVQWWDSPRDNKEDAE 485
            ....|.|:..::::.:.|
  Fly   443 TAVTQPWNESKESRRELE 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	163/463 (35%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	137/392 (35%)
CG2003	NP_651903.2	2A0114euk	23..456	CDD:129972	159/459 (35%)
CG2003	NP_651903.2	MFS	58..441	CDD:119392	137/391 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442707
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	9	8.890