DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and CG7881

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001286144.1	Gene:	CG7881 / 35521	FlyBaseID:	FBgn0033048	Length:	482	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	176/467 - (37%)
Similarity:	280/467 - (59%)	Gaps:	29/467 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NEK--FFGVRHVQCILCFFCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFN 78
            |||  ..|:||:|.:|.|..:.::|..|:::|||:|||||.:|      ||         .||
  Fly     4 NEKGPVIGIRHMQALLLFLAIVVNYTARLSVSVAIVAMTDAAT------TN---------LDF-- 51

  Fly    79 SERYYNFTQKEKGNLQASFFFGYIVTQVPGGYIAQRYGAKTMLMYGLGIAALITMLSPMSLQF-G 142
              ..||:...::..:.:||::||||||.|.|::.:|:|||.:|:......|:::.|:|..:.: |
  Fly    52 --PEYNWNGVQQSYILSSFYWGYIVTQFPAGFLVRRFGAKAVLLVPTLATAVLSGLTPYCVAWGG 114

  Fly   143 WVALAVMRFVMGLAQGAVHPATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVL 207
            |.|...:|.|.||.||.:.|..|..||||||.::|..||...||||..|:|:.:|:||.||:..:
  Fly   115 WQAFCTIRIVEGLFQGLIFPCIHEHLAKWSPPEDRNRLGAFAYSGADCGSVLAMASSGLIANGSM 179

  Fly   208 GWPSIFYL-GGACGFIWMVFWYLFSASTPEEHRLISPGELKYITDS--RSDGKMQSAEKLAPTPW 269
            |||.|||: .|.|| :|.:.|.||.|:.....|||...|.::|..|  |.||  ..|:|: |.||
  Fly   180 GWPGIFYVSAGTCG-LWCLLWVLFGANNAPSSRLIGSREREHIERSMKRQDG--FHAQKI-PIPW 240

  Fly   270 KAIFSSLPFLSLLVVHCTHIFGYWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVW 334
            :||:||.||.:||||.....:....:.:|.|:||..:..:|||..||.|:||::.|..:|:.::.
  Fly   241 RAIWSSSPFYALLVVRSAQGWANSTMQLQTPSYMHGVLEMDIKSNALYSALPFLAMWGMSYVYLV 305

  Fly   335 LSKVLQKKEGMSLSFNRKIFNSIGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQ 399
            .:.|...::.|||:..||..|::.:|.|..:||.:|::......||:.|:|:..|::..:.:|..
  Fly   306 FADVAMSRQWMSLTTLRKSINTVSYWGPAAALIGIGFLDKSQTTLAIALMTINAGLNAGSGIGSI 370

  Fly   400 VNHIDLSPNYAGTLMGITNCAANVMSGIAPVIVGQIVVDETSVTEWRLVFLLAAAFYFLGNLLFV 464
            :..||:|||::|.||.|.|...|:...:.|::||.||.:..|.::|::||.:.|..:|:|||:::
  Fly   371 LTIIDMSPNHSGMLMAIVNGIGNIFPLLTPLLVGVIVTESDSRSQWQIVFAMTAVVFFIGNLVYL 435

  Fly   465 IFGRTEVQWWDS 476
            |:|.|:.|.||:
  Fly   436 IWGTTDQQAWDA 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	173/462 (37%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	146/388 (38%)
CG7881	NP_001286144.1	2A0114euk	12..449	CDD:129972	172/459 (37%)
CG7881	NP_001286144.1	MFS	18..437	CDD:119392	163/441 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442706
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D428976at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	10	9.900