DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and VGlut

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster

Alignment Length:	462	Identity:	144/462 - (31%)
Similarity:	228/462 - (49%)	Gaps:	42/462 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFNSERYYNFTQKEKGNLQASFFFG 100
            :::..|.|:|.|.:....|.|.                        :.|:|...:.::.:|||:|
  Fly   108 IAFGMRCNMSAAKLKGEHNGTV------------------------FMNWTVAVESHVDSSFFWG 148

  Fly   101 YIVTQVPGGYIAQRYGAKTMLMYGLGI--AALITMLSP--MSLQFGWVALAVMRFVMGLAQGAVH 161
            |:|||:|||:||.::.|..  ::||.|  :|.:.:..|  |:|..|.|.:.| |.:.||.:|..:
  Fly   149 YLVTQIPGGFIASKFPANK--IFGLSIVSSATLHLFVPFAMTLMHGHVVICV-RVLQGLFEGVTY 210

  Fly   162 PATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVLGWPSIFYLGGACGFIWMVF 226
            ||.|.:...|:|..||..|.||.:||:..|.||.|..||.:||:| |:.:.||..|..|.||.:|
  Fly   211 PACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAV-GYQAPFYAYGVFGIIWYMF 274

  Fly   227 WYLFSASTPEEHRLISPGELKYITDSRSDGKMQSAEKLAPTPWKAIFSSLPFLSLLVVHCTHIFG 291
            |.......|.:|..||..|||||..|..:....:...|..|||:.:..|:|..:::|.:....:.
  Fly   275 WIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKTTPWREMMRSMPVYAIIVANFCRSWN 339

  Fly   292 YWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVWLSKVLQKKEGMSLSFNRKIFNS 356
            ::||::...:::|..:...:::...:.|||:::|..:..|...|:..|:|...:|.:..||:||.
  Fly   340 FYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNC 404

  Fly   357 IGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQVNHIDLSPNYAGTLMGITNCAA 421
            .|  ..|..|..|....:..|..|:..||..|..||....|:.|||:|::|.||..|||::|...
  Fly   405 GG--FGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIG 467

  Fly   422 NVMSGIAP-VIVGQIVVDETSVTEWRLVFLLAAAFYFLGNLLFVIFGRTEVQWWDSPRDNKEDAE 485
            .:...|.| .:.|.|..:.|..  |..||.|||..:.:|...:.||...|:|.|..|     .||
  Fly   468 TLAGIIVPYALDGLIQANPTGC--WTTVFTLAACVHLVGCTFYGIFASGELQPWAEP-----PAE 525

  Fly   486 QGTPLAP 492
            :....||
  Fly   526 EQKVWAP 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	139/445 (31%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	128/389 (33%)
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	135/435 (31%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	123/396 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451946
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000