DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	143/452 - (31%)
Similarity:	238/452 - (52%)	Gaps:	19/452 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFNSERYYNFTQKEKGNLQAS 96
            ||:  |:..|.||.||:|.|.:|||...........|             .:|:..:..|.:..|
  Rat    86 FCI--SFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTA-------------QFNWDPETVGLIHGS 135

  Fly    97 FFFGYIVTQVPGGYIAQRYGAKTMLMYGLGIAALITMLSPMSLQFGWVALAVMRFVMGLAQGAVH 161
            ||:||||||:|||:|:.::.|..:....:.:.:.:.|..|.:.:..:..:..:|.:.||.:|..:
  Rat   136 FFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTY 200

  Fly   162 PATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVLGWPSIFYLGGACGFIWMVF 226
            ||.|.:.:||:|..||..|.|..:.|:..|.||.:..:|.:. ..:||.|:||:.|..|.||.:|
  Rat   201 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLV-QYIGWASVFYIYGMFGIIWYMF 264

  Fly   227 WYLFSASTPEEHRLISPGELKYITDSRSDGKMQSAEKLAPTPWKAIFSSLPFLSLLVVHCTHIFG 291
            |.|.:...|..|..||..|..||..|..:|...::.....|||:..|:|||..:::|.:....:.
  Rat   265 WLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWT 329

  Fly   292 YWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVWLSKVLQKKEGMSLSFNRKIFNS 356
            ::|||:..|.|.::::...|.|..|||::|:|||.::......|:..|:.::.::.:..|||.|.
  Rat   330 FYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNC 394

  Fly   357 IGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQVNHIDLSPNYAGTLMGITNCAA 421
            .|..:....|:.:|:  :....:|::.|.|.||.||....||.|||:|::|.||..||||:|...
  Rat   395 GGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVG 457

  Fly   422 NVMSGIAPVIVGQIVVDETSVTEWRLVFLLAAAFYFLGNLLFVIFGRTEVQWWDSPRDNKED 483
            .:...:.|:|||.:...:|. .||:.|||:||..::.|.:.:.:|...|.|.|..|.:..|:
  Rat   458 TLSGMVCPLIVGAMTKHKTR-EEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	141/444 (32%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	123/384 (32%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	137/434 (32%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342501
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750