DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS14 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_001286591.1	Gene:	MFS14 / 46085	FlyBaseID:	FBgn0010651	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	434	Identity:	153/434 - (35%)
Similarity:	242/434 - (55%)	Gaps:	26/434 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RHVQCILCFFCLAMSYAWRVNLSVALVAMTDNSTSLAQNNTNTGVAPSEPGFDFFNSE--RYYNF 85
            |:...||.||...:.||.|||||||||.|.|::|:|..|.|:.............:::  :.|.:
Human    39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQW 103

  Fly    86 TQKEKGNLQASFFFGYIVTQVPGGYIAQRYGAKTMLMYGLGIAALITMLSPMSLQFGWVALAVMR 150
            ..:.:|.:..|||:|||:||:||||:|.:.|.|.:|.:|:...|::|:.:|::...|...|.|:|
Human   104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLR 168

  Fly   151 FVMGLAQGAVHPATHALLAKWSPADERGMLGTLCYSGAQFGTVVMLATSGFIADSVLGWPSIFYL 215
            .:.||.:|...||.||:.:.|:|..||..|.::.|:|||.|||:.|..||.|. ..:.|..:||.
Human   169 ALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYF 232

  Fly   216 GGACGFIWMVFWYLFSASTPEEHRLISPGELKYITDSRSDGKMQSAEKLAPTPWKAIFSSLPFLS 280
            .|..|..|.:.|....:.||::|:.||..|.:||..|..:  ..|::|  ..||..|..|||..:
Human   233 FGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRN--QLSSQK--SVPWVPILKSLPLWA 293

  Fly   281 LLVVHCTHIFGYWLLLMQIPTYMKKIYHVDIKKGALLSSLPYMVMLLLSFFFVWLSKVL--QKKE 343
            ::|.|.::.:.::.||..:|||||:|...::::...||||||:..        ||..:|  |..:
Human   294 IVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGS--------WLCMILSGQAAD 350

  Fly   344 GMSLSFN------RKIFNSIGHWIPMLSLIALGYVPADNAPLAVTLLTLTVGISGATYLGFQVNH 402
            .:...:|      |:||:.||...|.:.|:|.|::..|.: |||..||::..:.|....||.:||
Human   351 NLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYS-LAVAFLTISTTLGGFCSSGFSINH 414

  Fly   403 IDLSPNYAGTLMGITNCAANVMSGIAPVIVGQIVVDETSVTEWR 446
            :|::|:|||.|:||||..|.:...:.|||...:..|  :..:||
Human   415 LDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPD--AGVQWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS14	NP_001286591.1	2A0114euk	19..477	CDD:129972	153/434 (35%)
MFS14	NP_001286591.1	MFS	81..466	CDD:119392	131/374 (35%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	152/431 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840